PPP2R1A
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Official Full Name
protein phosphatase 2, regulatory subunit A, alpha -
Overview
This gene encodes a constant regulatory subunit of protein phosphatase 2. Protein phosphatase 2 is one of the four major Ser/Thr phosphatases, and it is implicated in the negative control of cell growth and division. It consists of a common heteromeric core enzyme, which is composed of a catalytic subunit and a constant regulatory subunit, that associates with a variety of regulatory subunits. The constant regulatory subunit A serves as a scaffolding molecule to coordinate the assembly of the catalytic subunit and a variable regulatory B subunit. This gene encodes an alpha isoform of the constant regulatory subunit A. Alternatively spliced transcript variants have been described. -
Synonyms
PPP2R1A;protein phosphatase 2, regulatory subunit A, alpha;protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform , protein phosphatase 2 (formerly 2A), regulatory subunit A, alpha isoform;serine/threonine-protein phosphatase 2A 65 kDa regulatory subunit A alpha isoform;PP2A Aalpha;PR65A;protein phosphatase 2;65kDa regulatory subunit A;protein phosphatase 2A;regulatory subunit A;alpha isoform;6330556D22Rik;Alpha isoform of regulatory subunit A, protein phosphatase;DKFZp470L0914;Medium tumor antigen-associated 61 kDa protein;MGC128399;MGC786;MGC83000;MGC95083;PP2A;PP2A subunit A PR65-alpha isoform;PP2A subunit A R1 alpha isoform;PP2A, subunit A, PR65-alpha isoform;PP2A, subunit A, R1-alpha isoform;ppp2r1a-b;PR65;Protein phosphatase 2 (formerly 2A), regulatory subunit A (PR 65), alpha isoform;Protein phosphatase 2 (Formerly 2A), regulatory subunit A (PR 65), alpha isoform, isoform CRA_a;Protein phosphatase 2 (formerly 2A), regulatory subunit A,;Protein phosphatase 2 regulatory subunit A alpha isoform;Protein phosphatase 2, 65-KD regulatory subunit A, alpha;Protein phosphatase 2, regulatory subunit A, alpha isoform;Protein phosphatase 2, structural/regulatory subunit A, alpha;Serine threonine protein phosphatase 65 kDa;Serine/threonine protein phosphatase 2A 65 KDA regulatory subunit A alpha isoform;PP2A subunit A isoform R1-alpha;PP2A subunit A isoform PR65-alpha;protein phosphatase 2 (formerly 2A), regulatory subunit A (P;PP2AAALPHA;PP2A-Aalpha
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- Rhesus macaque
- Insect Cell
- E.coli
- Mammalian Cell
- HEK293
- Mammalian cells
- Sf9 insect cells
- HEK293T
- His
- GST
- Non
- His&Fc&Avi
- Flag
- Myc&DDK
Involved Pathway
PPP2R1A involved in several pathways and played different roles in them. We selected most pathways PPP2R1A participated on our site, such as mRNA surveillance pathway,Sphingolipid signaling pathway,Oocyte meiosis, which may be useful for your reference. Also, other proteins which involved in the same pathway with PPP2R1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| AMPK signaling pathway | IGF1R,CFTR,CREB1,PIK3R3,PPP2R5E,LIPE,STRADA,LEP,FOXO3,PIK3CD |
| Adrenergic signaling in cardiomyocytes | CACNG3,PPP1R1A,CACNB4,AKT2L,PRKACB,CAMK2D2,KCNQ1,VMHCL,CACNG7A,PIK3R3B |
| TGF-beta signaling pathway | TGFBR1A,CUL1,TGFBR1,EP300,LEFTY2,PPP2CA,CHRD,ACVR1,AMHR2,SP1 |
| Dopaminergic synapse | PPP3CC,KCNJ3,CREB3L1,GNG4,ARRB2,CREB3L2,CALM2,CAMK2A,PPP3CA,GNG2 |
| Sphingolipid signaling pathway | MAP3K5,FCER1G,PPP2R5C,TRAF2,SMPD1,PIK3CD,NSMAF,ASAH1,MAPK13,NFKB1 |
| mRNA surveillance pathway | NCBP2,PPP1CAA,PPP2CA,SSU72,pab1,PABPN1,PPP2R1B,PPP2R3C,NXF3,MSI1 |
| Long-term depression | PLA2G4F,PRKCB,MAP2K2,GNA11,GNAI1,GNA12,GUCY1B3,MAP2K1,LYN,PRKG2 |
| Tight junction | MYHZ1.1,PTENB,SHROOM4,ASH1L,CLDND,RHOA,HRAS,GNAI3,ZAK,MAGI2 |
| Chagas disease (American trypanosomiasis) | Ccl12,CFLAR,MAP2K4,TGFBR2,IL12B,CD3G,MAPK1,GNA15,TICAM1,FADD |
Protein Function
PPP2R1A has several biochemical functions, for example, antigen binding,protein binding,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PPP2R1A itself. We selected most functions PPP2R1A had, and list some proteins which have the same functions with PPP2R1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | PACSIN2,NACA,AHSP,ATP7A,FAM164C,ZMYM5,NDNL2,KCNMA1,KRR1,APOBEC1 |
| protein phosphatase type 2A regulator activity | PPP2R4,PPP2R5A,PPP2R5C,pab1,PPP2R3A,PPP2R5EB,ARPP19,PPP2R2BB,PPP2R5E,EIF2AK2 |
| protein serine/threonine phosphatase activity | PPM1BA,PPM1B,LCK,PPM1E,UBLCP1,PPM1DB,CDC14B,MTMR6,PPM1J,PPP1R3C |
| protein heterodimerization activity | WHRN,ZFP423,HIST1H4F,NFYBA,MTTP,IL12A,PPP2R4,HIST1H2B8,HIST1H3H,JDP2 |
| antigen binding | TGFB1,Ighg2b,LILRA2,LCK,TSPAN4,SPON2,Ighg,IGKC,IgG3,LILRA1 |
Interacting Protein
PPP2R1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PPP2R1A here. Most of them are supplied by our site. Hope this information will be useful for your research of PPP2R1A.
PPP2CA;PPP2R2A
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References
- Becsi, B; Dedinszki, D; et al. Identification of protein phosphatase interacting proteins from normal and UVA-irradiated HaCaT cell lysates by surface plasmon resonance based binding technique using biotin-microcystin-LR as phosphatase capturing molecule. JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY 138:240-248(2014).
- Yao, MY; Rogers, NM; et al. Thrombospondin-1 Activation of Signal-Regulatory Protein-alpha Stimulates Reactive Oxygen Species Production and Promotes Renal Ischemia Reperfusion Injury. JOURNAL OF THE AMERICAN SOCIETY OF NEPHROLOGY 25:1171-1186(2014).
