POU5F1
-
Official Full Name
POU class 5 homeobox 1 -
Overview
This gene encodes a transcription factor containing a POU homeodomain that plays a key role in embryonic development and stem cell pluripotency. Aberrant expression of this gene in adult tissues is associated with tumorigenesis. This gene can participate in a translocation with the Ewings sarcoma gene on chromosome 21, which also leads to tumor formation. Alternative splicing, as well as usage of alternative AUG and non-AUG translation initiation codons, results in multiple isoforms. One of the AUG start codons is polymorphic in human populations. Related pseudogenes have been identified on chromosomes 1, 3, 8, 10, and 12. [provided by RefSeq, Oct 2013] -
Synonyms
POU5F1;POU class 5 homeobox 1;OCT3;OCT4;OTF3;OTF4;OTF-3;Oct-3;Oct-4;POU domain, class 5, transcription factor 1;octamer-binding protein 3;octamer-binding protein 4;POU domain transcription factor OCT4;octamer-binding transcription factor 3;POU-type homeodomain-containing DNA-binding protein
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- HEK293
- Mammalian Cell
- Mammalian cells
- HEK293T
- 11R
- His
- Myc&DDK
- Arg
- TAT
- Non
- His&Fc&Avi
- Flag
- His&B2M
Involved Pathway
POU5F1 involved in several pathways and played different roles in them. We selected most pathways POU5F1 participated on our site, such as Signaling pathways regulating pluripotency of stem cells, which may be useful for your reference. Also, other proteins which involved in the same pathway with POU5F1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Signaling pathways regulating pluripotency of stem cells | HOXB1,ESX1,SMAD9,SMAD2,INHBE,FZD7,PIK3R2,PCGF6,WNT16,WNT1 |
Protein Function
POU5F1 has several biochemical functions, for example, DNA binding,RNA polymerase II transcription factor activity, sequence-specific DNA binding,miRNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by POU5F1 itself. We selected most functions POU5F1 had, and list some proteins which have the same functions with POU5F1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | ZFP11,HIST1H4K,NR1I3,DACH2,ZNF529,HER1,ZNF32,PIAS4,HIF1AL,RABGAP1 |
| transcription factor binding | FOXA1,DAXX,MECP2,CREG1,PARP1,PDX1,FOSB,UBA2,ZFPM2,DIP2C |
| RNA polymerase II transcription factor activity, sequence-specific DNA binding | FOXC1A,ATF4B2,BETA3,FOXK1,JUN,SOX9B,ZNF488,FOXN1,NPAS1,ELF2A |
| poly(A) RNA binding | SUMO1,RPL13,UBE2N,TNS1,RPS12,EEF2,RBM28,EIF5,HNRPLL,D19BWG1357E |
| transcription regulatory region DNA binding | TRP63,IKZF4,FOS,GFI1,MTERFD1,ZFP639,MESP1,FOXI1,SNCA,GABPA |
| sequence-specific DNA binding | MIXL1,ZGPAT,ENG1A,ENG1B,NFIL3-2,CHES1,HHEX,DMRT3A,HOXC12,FOXJ2 |
| ubiquitin protein ligase binding | NDUFS2,UBOX5,PARK2,TSG101,TRIB2,PACRG,SMC6,GRIK2,CUL2,UBE2G1 |
| transcriptional repressor activity, RNA polymerase II transcription regulatory region sequence-specific binding | SATB1,CGGBP1,ASCL3,KLF12,ETV7,PURB,BCL6AB,MITF,MNT,DMBX1 |
| protein binding | ARHGEF38,NOTCH2NL,TBRG4,Rhox5,ZNF625,KRT80,AP2B1,SHC3,LETM1,NT5C3B |
Interacting Protein
POU5F1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with POU5F1 here. Most of them are supplied by our site. Hope this information will be useful for your research of POU5F1.
WWP2;Hmgb1;e1a_ade12;E1A;FOXD3;UBE2E1;UBA1;NCL;Hmgb2;SOX2;htrA;SOX17
Resources
Research Area
Primordial Germ Cell MarkersCancer Stem Cell Transcription Factors
Embryonic and Induced Pluripotent Stem Cell Markers
Pluripotent Stem Cell Transcription Factors
Related Services
Related Products
References
- Lippok, B; Song, S; et al. Pou5f1 Protein Expression and Posttranslational Modification During Early Zebrafish Development. DEVELOPMENTAL DYNAMICS 243:468-477(2014).
- Akhondi, MM; Mohazzab, A; et al. Propagation of human germ stem cells in long-term culture. IRANIAN JOURNAL OF REPRODUCTIVE MEDICINE 11:551-558(2013).
