PLA2G12A
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Official Full Name
phospholipase A2, group XIIA -
Overview
Secreted phospholipase A2 (sPLA2) enzymes liberate arachidonic acid from phospholipids for production of eicosanoids;and exert a variety of physiologic and pathologic effects. Group XII sPLA2s, such as PLA2G12A, have relatively low;specific activity and are structurally and functionally distinct from other sPLA2s (Gelb et al., 2000 (PubMed;11031251)). -
Synonyms
PLA2G12A;phospholipase A2, group XIIA;phospholipase A2, group XII , PLA2G12;group XIIA secretory phospholipase A2;EC 3.1.1.4;Group XIIA secretory phospholipase A2 precursor;GXII sPLA2;Phosphatidylcholine 2 acylhydrolase GXII;Phospholipase A2 group XIIA;PLA2G12;sPLA2-XII;group XII secreted phospholipase A2;group XIIA secreted phospholipase A2;phosphatidylcholine 2-acylhydrolase 12A;GXII;ROSSY
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- Zebrafish
- E.coli
- Mammalian Cell
- HEK293
- Yeast
- Mammalian cells
- Insect Cell
- HEK293T
- GST
- His
- Non
- His&T7
- His&Fc&Avi
- Myc&DDK
- Flag
- His&Myc
- His&SUMO
Involved Pathway
PLA2G12A involved in several pathways and played different roles in them. We selected most pathways PLA2G12A participated on our site, such as Glycerophospholipid metabolism,Ether lipid metabolism,Arachidonic acid metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with PLA2G12A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Fat digestion and absorption | PLA2G2A,GOT2,FABP1,PLA2G10,SCARB1,PLA2G2E,APOA4,PPAP2A,PLA2G12B,APOA1 |
| Ether lipid metabolism | PLA2G4F,PLA2G4B,LPCAT4,CEPT1,PLA2G4D,PPAP2B,AGPS,PLD2,UGT8,PLA2G2A |
| Glycerophospholipid metabolism | PLA2G4D,PLA2G2F,DGKA,PCYT1A,CHPT1,AGPAT2,ETNK2,CDS1,EPT1,LPIN2 |
| Metabolic pathways | LPIN1,ATP6V0B,GATC,GNSA,ACLY,AK1,HSD17B8,GALM,HSD17B12B,PON2 |
| Linoleic acid metabolism | CYP2P8,CYP3A41A,PLA2G5,CYP2C38,CYP2J6,PLA2G1B,CYP2C37,PLA2G10,PLA2G4D,CYP3A25 |
| Pancreatic secretion | PLCB3,TRPC1,ATP1A2,CPA3,CLCA5,PLA2G1B,RAB3D,BST1,CPA2,PNLIP |
| Vascular smooth muscle contraction | PTGIR,CALM3A,PRKCBA,PRKCBB,CALM2,ROCK2A,GNAQ,PRKACAB,CACNA1D,CALM1A |
| Ras signaling pathway | INS2,FGF16,PIK3CD,RAB5B,PRKACG,NGFR,FGFR1,PLA1A,CALML3,FGF11 |
| alpha-Linolenic acid metabolism | PLA2G4AA,PLA2G4A,PLA2G4C,PLA2G5,PLA2G1B,ACAA1A,PLA2G2F,ACAA1,PLA2G3,PLA2G4D |
Protein Function
PLA2G12A has several biochemical functions, for example, calcium ion binding,calcium-dependent phospholipase A2 activity. Some of the functions are cooperated with other proteins, some of the functions could acted by PLA2G12A itself. We selected most functions PLA2G12A had, and list some proteins which have the same functions with PLA2G12A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | PCDHB7,SYT7,RCVRNA,NECAB2,RPH3AL,PLCB2,ELTD1,VWCE,PLCH1,CDH18 |
| calcium-dependent phospholipase A2 activity | PLA2G4A,PLA2G4F,PLA2G5,PLA2G3,PLA2G1B,PLA2G2A,PLA2G4B |
Interacting Protein
PLA2G12A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PLA2G12A here. Most of them are supplied by our site. Hope this information will be useful for your research of PLA2G12A.
DVL2;RB1;UMPS;YWHAG;RPS6;RPS15;MEF2C;TMEM37;UCK1;EPB41L3
Resources
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References
- Peuravuori, H; Kollanus, S; et al. Expression of group XIIA phospholipase A(2) in human digestive organs. APMIS 122:1171-1177(2014).
- Ee, SM; Lo, YL; et al. Distribution of Secretory Phospholipase A2 XIIA in the Brain and its Role in Lipid Metabolism and Cognition. MOLECULAR NEUROBIOLOGY 50:60-75(2014).
