PIK3CB
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Official Full Name
phosphoinositide-3-kinase, catalytic, beta polypeptide -
Overview
This gene encodes an isoform of the catalytic subunit of phosphoinositide 3-kinase (PI3K). These kinases are important;in signaling pathways involving receptors on the outer membrane of eukaryotic cells and are named for their catalytic;subunit. The encoded protein is the catalytic subunit for PI3Kbeta (PI3KB). PI3KB has been shown to be part of the;activation pathway in neutrophils which have bound immune complexes at sites of injury or infection. Alternative;splicing results in multiple transcript variants. -
Synonyms
PIK3CB;phosphoinositide-3-kinase, catalytic, beta polypeptide;PIK3C1;phosphatidylinositol-4,5-bisphosphate 3-kinase catalytic subunit beta isoform;PI3K-beta;PtdIns-3-kinase p110;PI3-kinase subunit beta;PI3-kinase p110 subunit beta;ptdIns-3-kinase
Recombinant Proteins
- Human
- Mouse
- Chicken
- Rat
- E.coli
- Insect Cell
- Insect (sf21)
- Mammalian Cell
- Sf9 Insect Cell
- HEK293
- Chicken
- His
- Flag
- GST
- Non
- His&Fc&Avi
Involved Pathway
PIK3CB involved in several pathways and played different roles in them. We selected most pathways PIK3CB participated on our site, such as Inositol phosphate metabolism,ErbB signaling pathway,Ras signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with PIK3CB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Natural killer cell mediated cytotoxicity | ICAM1,RAET1D,NCR1,FCGR3A,SH2D1B,MAPK1,HLA-A,FCGR4,IFNGR1,HLA-B |
| B Cell Receptor Signaling Pathway | CD79A,ITK,PIK3CA,FCGR2B,CMTM3,ACTR3,PPP3CB,NFATC3,KRAS,RAC3 |
| Fc gamma R-mediated phagocytosis | ASAP1,PIK3R3,BIN1,FCGR1A,NCF1,SPHK2,CDC42,MAP2K1,AKT1,PRKCB |
| FoxO signaling pathway | SMAD3A,IGF1,SMAD4,CDKN2D,IRS2,MAPK10,MAPK1,INSB,PLK2,CCNB3 |
| AMPK signaling pathway | MTOR,PPP2R2D,CREB3,G6PC,CREB3L3,PDPK1,PPP2R1B,ACACB,LIPE,PPP2R5E |
| Chronic myeloid leukemia | TGFBR2,TGFB1,CRKL,CCND1,TRP53,PIK3CD,AKT1,STAT5A,SHC3,STAT5B |
| Fc epsilon RI signaling pathway | PIK3CA,MAPK9,LCP2,PRKCA,MAP2K2,PLCG1,MAPK13,MAP2K3,PIK3CG,PIK3R5 |
| Pancreatic cancer | CCND1,SMAD2,RAC3,RALB,TGFB1,PIK3R3,AKT2,CASP9,MAPK9,PIK3R1 |
| Prostate Cancer | FOXA1,IGF1R,CCNE2,CREB5,PDGFA,TGFA,TP53,MAP2K2,BAD,MAPK1 |
Protein Function
PIK3CB has several biochemical functions, for example, 1-phosphatidylinositol-3-kinase activity,1-phosphatidylinositol-4-phosphate 3-kinase activity,ATP binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PIK3CB itself. We selected most functions PIK3CB had, and list some proteins which have the same functions with PIK3CB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| 1-phosphatidylinositol-3-kinase activity | PIK3CD,PIK3CA,PIK3C3,PIK3R3,PIK3C2B,PIK3C2G,PIK3C2A,ATM,PIK3CG |
| phosphatidylinositol 3-kinase activity | PIK3CA,PIK3CD,PIK3CG,PIK3C2A |
| insulin receptor substrate binding | PIK3R1,PIK3CA,JAK2,IGF1RB,INSRA,PRKCD,INSRB,IGF1R,INSR,PRKCZ |
| phosphatidylinositol-4,5-bisphosphate 3-kinase activity | PIK3CA,PIK3CD,PIK3CG |
| 1-phosphatidylinositol-4-phosphate 3-kinase activity | PIK3CD,PIK3C2A,PIK3C2G,PIK3CA,PIK3CG,PIK3C2B |
| protein binding | RPSA,SPN,SERPINB9,GNB2L1,PRKACB,CSNK1E,TRAPPC2,PLIN5,PRAP1,LCMT1 |
| ATP binding | VARS2,MYO7A,DHX32A,CHORDC1,NTRK3,NLRP2,DHX58,FKBP4,UPF1,SMC2 |
Interacting Protein
PIK3CB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PIK3CB here. Most of them are supplied by our site. Hope this information will be useful for your research of PIK3CB.
PIK3R2;PIK3R1;PIK3R3;YWHAQ;HCK;TFCP2;ALAS1;HPS6;DVL3;NS;NS;ERBB3
PIK3CB Related Signal Pathway
Resources
Research Area
Cancer Drug TargetsApoptosis Intracellular Kinases
Diabetic Peripheral Neuropathy
Intracellular Kinases in the Akt Pathway
PI 3-Kinases (Phosphoinositide 3-Kinases)
Intracellular Signaling Molecules in Angiogenesis
Apical-basal Polarity Effectors
T Follicular Helper (Tfh) Cells
PI3K Pathway
Related Services
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References
