PAK6
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Official Full Name
p21 protein (Cdc42/Rac)-activated kinase 6 -
Overview
This gene encodes a member of the p21-activated kinase (PAK) family. The proteins of this family are Rac/Cdc42-associated Ste20-like Ser/Thr protein kinases, characterized by a highly conserved amino-terminal Cdc42/Rac interactive binding (CRIB) domain and a carboxyl-terminal kinase domain. PAK kinases are implicated in the regulation of a number of cellular processes, including cytoskeleton rearrangement, apoptosis and the MAP kinase signaling pathway. The protein encoded by this gene was found to interact with androgen receptor (AR), which is a steroid hormone-dependent transcription factor that is important for male sexual differentiation and development. This gene was found to be highly expressed in testis and prostate tissues and the encoded protein was shown to cotranslocate into the nucleus with AR in response to androgen. Alternatively spliced transcript variants encoding the same protein have been found for this gene. -
Synonyms
PAK6;p21 protein (Cdc42/Rac)-activated kinase 6;PAK5;p21-activated kinase 6;p21(CDKN1A)-activated kinase 6;p21-activated protein kinase 6;EC 2.7.11.1
Recombinant Proteins
- Human
- Mouse
- Rhesus macaque
- E.coli
- Mammalian Cell
- Insect Cell
- Wheat Germ
- Sf9 Insect Cell
- HEK293
- In Vitro Cell Free System
- Insect (sf21)
- His
- GST
- Non
- His&Fc&Avi
Involved Pathway
PAK6 involved in several pathways and played different roles in them. We selected most pathways PAK6 participated on our site, such as ErbB signaling pathway,Ras signaling pathway,Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with PAK6 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Focal adhesion | PTK2,BAD,ITGA3B,LAMB4,CAPN2L,VTN,ITGA2,CAV2,ITGA6B,RHOAB |
| Renal cell carcinoma | AKT1,FH1,SOS1,CUL2,HRAS,GAB1,TGFB2,NRAS,CDC42,HGF |
| ErbB signaling pathway | CAMK2D1,STAT5A,ABL2,BTC,ERBB3,PLCG2,SHC1,AKT1,RPS6KB1,CDKN1BA |
| Ras signaling pathway | RASGRP3,CALM4,RAC1,CALML3,AKT1,PRKCG,FGF4,FGFR3,RASA3,FGF22 |
| Axon guidance | JAK1,CNTN1,FRS2B,LRRC4C,SEMA3E,UNC5D,UNC5C,Sema3f,ROCK2,DPYSL5 |
| T cell receptor signaling pathway | IL5,IKBKG,MAP2K7,VAV2,CD8B1,NFKBIE,NFKBIA,PDCD1,SHB,GRAP2 |
| Regulation of Actin Cytoskeleton | BRK1,FGD,MYL10,BRAF,ITGA10,VAV1,PPP1CB,TMSB,FN1A,FGF6B |
Protein Function
PAK6 has several biochemical functions, for example, ATP binding,Rac GTPase binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by PAK6 itself. We selected most functions PAK6 had, and list some proteins which have the same functions with PAK6. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | PRPF4BB,ABCB11,PIP4K2B,HKDC1,HSP70L,TBCK,STYK1,PCXA,RECQL,PFKP |
| protein binding | PPP4R1,BCL2L11,ATXN1,SLC22A7,GNL3,RIPK4,RPS11,EVI5L,ITSN2,IFT122 |
| protein serine/threonine kinase activity | MAP4K4,PSKH2,MAP4K6,PAK3,MAP3K4,CAMK1GA,NEK6,LATS1,ZAK,RIPK4 |
| Rac GTPase binding | ARFIP2,ITPKA,PAK3,CORO1C,SRGAP2A,NOX1,RALBP1,SRGAP1,SRGAP2,PAK4 |
Interacting Protein
PAK6 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with PAK6 here. Most of them are supplied by our site. Hope this information will be useful for your research of PAK6.
LRRK2;RHOJ;PKM;LRRK1;HSP90AB1;YWHAQ;SNX2;CDK1;CDC42;SEMA3B;MAPK14;TPD52L1;NEK6
PAK6 Related Signal Pathway
Resources
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References
- Liu, WS; Liu, HO; et al. Prognostic Significance of p21-activated Kinase 6 Expression in Patients with Clear Cell Renal Cell Carcinoma. ANNALS OF SURGICAL ONCOLOGY 21:S575-S583(2014).
- Zapatero, A; Morente, M; et al. Predictive value of PAK6 and PSMB4 expression in patients with localized prostate cancer treated with dose-escalation radiation therapy and androgen deprivation therapy. UROLOGIC ONCOLOGY-SEMINARS AND ORIGINAL INVESTIGATIONS 32:1327-1332(2014).
