NOTCH3
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Official Full Name
notch 3 -
Overview
This gene encodes the third discovered human homologue of the Drosophilia melanogaster type I membrane protein notch. In Drosophilia, notch interaction with its cell-bound ligands (delta, serrate) establishes an intercellular signalling pathway that plays a key role in neural development. Homologues of the notch-ligands have also been identified in human, but precise interactions between these ligands and the human notch homologues remains to be determined. Mutations in NOTCH3 have been identified as the underlying cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL). [provided by RefSeq, Jul 2008] -
Synonyms
NOTCH3;notch 3;IMF2;CASIL;CADASIL;neurogenic locus notch homolog protein 3;Notch homolog 3
Recombinant Proteins
- Human
- Mouse
- Rat
- Zebrafish
- HEK293
- Sf21 Insect Cell
- Insect Cell
- Wheat Germ
- Mammalian Cell
- E.coli
- His
- Fc
- Non
- His&GST
- His&TRxA
- His&Fc&Avi
- GST
- His&Avi
Involved Pathway
NOTCH3 involved in several pathways and played different roles in them. We selected most pathways NOTCH3 participated on our site, such as Dorso-ventral axis formation,Notch signaling pathway,Thyroid hormone signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with NOTCH3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | MFAP5,APH1B,NUMB,MYCBP,YY1,ADAM17A,MAML2,NOTCH4,KAT2A,PSEN1 |
| Dorso-ventral axis formation | NOTCH1A,SPIRE1A,PIWIL1,CPEB2,SOS1,GRB2,ETS1,MAPK3,PIWIL2,GRB2A |
| Thyroid hormone signaling pathway | PLCG1,RCAN1,ATP1A3,TP53,MAP2K2,ATP1A4,HDAC2,ESR1,ITGB3,HDAC3 |
| MicroRNAs in cancer | CCND1,TPM1,HNRNPK,TNN,Abcb1b,CCNE1,NOTCH2,RDX,RPS6KA5,PLCG1 |
Protein Function
NOTCH3 has several biochemical functions, for example, calcium ion binding,enzyme binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NOTCH3 itself. We selected most functions NOTCH3 had, and list some proteins which have the same functions with NOTCH3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| enzyme binding | THRB,CAV1,PLSCR4,NR5A1,HAND1,JUN,ANK1,CYB5A,MAPT,NKX2-1 |
| protein binding | EPHA3,TNFRSF6B,PCTP,TFF1,OPA1,RPS14,EME1,CCNC,ELK4,PSAP |
| calcium ion binding | THBS4B,CANX,PLCB1,PADI3,SLC25A25,PCDH2G2,DOC2D,DGKAA,PCDH10A,PCDHGA1 |
Interacting Protein
NOTCH3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NOTCH3 here. Most of them are supplied by our site. Hope this information will be useful for your research of NOTCH3.
Psma1;ABL1;NCK1;JAG1;LRP1;ANKRD28;FBLN1;CSNK2B;opuD;ald1;q8d176_yerpe;rhsA5;E2F3
NOTCH3 Related Signal Pathway
Resources
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References
- Huntzicker, EG; Hotzel, K; et al. Differential Effects of Targeting Notch Receptors in a Mouse Model of Liver Cancer. HEPATOLOGY 61:942-952(2015).
- Minuzzo, S; Agnusdei, V; et al. DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice. CARCINOGENESIS 36:115-121(2015).
