NMNAT1
-
Official Full Name
nicotinamide nucleotide adenylyltransferase 1 -
Overview
This gene encodes an enzyme which catalyzes a key step in the biosynthesis of the coenzyme NAD. The encoded protein is one of several nicotinamide nucleotide adenylyltransferases. Studies in Drosophila and mammalian neurons have shown the encoded protein can confer protection to damaged neurons. This protection requires enzymatic activity which increases NAD levels and activates a nuclear deacetylase which is the protective molecule. Pseudogenes of this gene are located on chromosomes 1, 3, 4, 14 and 15. [provided by RefSeq, Dec 2011] -
Synonyms
NMNAT1;nicotinamide nucleotide adenylyltransferase 1;LCA9;NMNAT;PNAT1;nicotinamide mononucleotide adenylyltransferase 1;NMN adenylyltransferase 1;NaMN adenylyltransferase 1;Lebers congenital amaurosis 9;pyridine nucleotide adenylyltransferase 1;nicotinate-nucleotide adenylyltransferase 1
Recombinant Proteins
- Human
- Zebrafish
- Mouse
- E.coli
- Sf21 Insect Cell
- Insect Cell
- Mammalian Cell
- HEK293
- Mammalian cells
- HEK293T
- Wheat Germ
- In Vitro Cell Free System
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
NMNAT1 involved in several pathways and played different roles in them. We selected most pathways NMNAT1 participated on our site, such as Nicotinate and nicotinamide metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with NMNAT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | EXTL2,Aldh1a7,UCK2A,ACSBG2,SGSH,B4GALT6,CYP2C39,PIP5K1AA,BST1,ATP6V0E |
| Nicotinate and nicotinamide metabolism | NADSYN1,AOX4,NMRK2,PNP5A,MIBP2,NNMT,NMNAT3,NT5C1BA,AOX3L1,NT5C3B |
Protein Function
NMNAT1 has several biochemical functions, for example, ATP binding,nicotinamide-nucleotide adenylyltransferase activity,nicotinate-nucleotide adenylyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by NMNAT1 itself. We selected most functions NMNAT1 had, and list some proteins which have the same functions with NMNAT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| nicotinate-nucleotide adenylyltransferase activity | ABL1,NMNAT3,NMNAT2 |
| ATP binding | MCM4,CCC2,OAS2,MYO1G,ERCC6L2,PAK7,UBE2E1,EPHB3,PRKCH,MAP4K2 |
| protein binding | USP25,KIAA0319L,LRR1,TTLL6,SRSF7,DLL1,CEP170L,FOXP2,MAT2B,SPDL1 |
| nicotinamide-nucleotide adenylyltransferase activity | NMNAT3,NMNAT2 |
Interacting Protein
NMNAT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NMNAT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NMNAT1.
SIRT1;CCNC;KPNA2;MSX1;NEK3;SIK1;FLOT2;NTRK2;Espl1;Osgep;Spire2;Dctn3
Resources
Related Services
Related Products
References
