NEK1
-
Official Full Name
NIMA (never in mitosis gene a)-related kinase 1 -
Overview
The protein encoded by this gene is a serine/threonine kinase involved in cell cycle regulation. The encoded protein is found in a centrosomal complex with FEZ1, a neuronal protein that plays a role in axonal development. Defects in this gene are a cause of polycystic kidney disease (PKD). Several transcript variants encoding different isoforms have been found for this gene. -
Synonyms
NEK1;NIMA (never in mitosis gene a)-related kinase 1;serine/threonine-protein kinase Nek1;KIAA1901;NY REN 55;nimA-related protein kinase 1;protein-serine/threonine kinase;renal carcinoma antigen NY-REN-55;never in mitosis A-related kinase 1;SRPS2
Recombinant Proteins
- Human
- Mouse
- E.coli
- Sf9 Insect Cell
- Wheat Germ
- Mammalian Cell
- Insect cell
- HEK293
- His
- GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| NEK1-3124H | Recombinant Human NEK1 protein, His-tagged | E.coli | Human | His | 557-740 aa |
|
| NEK1-1437M |
Active Recombinant Mouse NEK1, GST-tagged
|
Sf9 Insect Cell | Mouse | GST | 1-495 aa |
|
| NEK1-29277TH | Recombinant Human NEK1 | Wheat Germ | Human | Non | 100 amino acids |
|
| NEK1-705H | Recombinant Human NEK1 | Mammalian Cell | Human | His |
|
|
| Nek1-2039M | Recombinant Mouse Nek1 Protein, GST-tagged | Insect cell | Mouse | GST | 1-495 |
|
| NEK1-2993H | Active Recombinant Human NEK1 Protein, GST-tagged | Insect cell | Human | GST | 1-505 |
|
| NEK1-301539H | Recombinant Human NEK1 protein, GST-tagged | E.coli | Human | GST | Lys557-Asp740 |
|
| NEK1-3610H | Recombinant Human NEK1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
|
|
| NEK1-3610H-B | Recombinant Human NEK1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
|
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| NEK1-9928H | Active Recombinant Human NEK1 Protein, GST-tagged | Insect cell | Human | GST | 1-477 |
|
Involved Pathway
NEK1 involved in several pathways and played different roles in them. We selected most pathways NEK1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with NEK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
NEK1 has several biochemical functions, for example, ATP binding,kinase activity,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by NEK1 itself. We selected most functions NEK1 had, and list some proteins which have the same functions with NEK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TICAM2,SNTB2,HHIP,DACH1,PFDN2,NEU4,MAP2K3,BAG1,PRKACA,DMKN |
| ATP binding | EEF2K,MAP3K3,PSKH1,ABCG3,TRP53,PAK6,SYK,ACSM2,RTEL1,DDX20 |
| metal ion binding | CIZ1B,ZNF239,RYBPB,NUDT19,ARHGAP29B,ZFP367,BCMO1,GTF2H3,RNF144AA,THAP2 |
| protein serine/threonine kinase activity | PIM1,STK33,ADCK1,PRKACAB,NEK2,MAPK12A,ALPK1,ACVR1L,DYRK2,CSNK1DB |
| protein kinase activity | STK30,MAP4K5,VSIG8B,STK25,MAPKAPK2B,CSNK1DB,JAK2,CDK1,PIK3CG,MAPKAPK2 |
| protein tyrosine kinase activity | EPHA4B,MAP3K11,EPHB2B,CLK3,DSTYK,ZNF143B,EPHB3A,ZAP70,CLK4,LTK |
| kinase activity | IGF1RA,PLAUA,CDK5R1,AKT2L,PDXK,BMPR1AA,NADKD1,MAP4K6,INSRB,PHKG1B |
Interacting Protein
NEK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with NEK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of NEK1.
LRRK2;FEZ1;FEZ2;saicar;PKM;LRRK1;ATRX;TSC2;MRE11A;YWHAH;TP53BP1;PPP2R5D;ZNF350;EXOSC4
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