MMP12
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Official Full Name
matrix metallopeptidase 12 (macrophage elastase) -
Overview
Proteins of the matrix metalloproteinase (MMP) family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. Most MMPs are secreted as inactive proproteins which are activated when cleaved by extracellular proteinases. It is thought that the protein encoded by this gene is cleaved at both ends to yield the active enzyme, but this processing has not been fully described. The enzyme degrades soluble and insoluble elastin. It may play a role in aneurysm formation and studies in mice suggest a role in the development of emphysema. The gene is part of a cluster of MMP genes which localize to chromosome 11q22.3. [provided by RefSeq, Jul 2008] -
Synonyms
MMP12;matrix metallopeptidase 12 (macrophage elastase);ME;HME;MME;MMP-12;macrophage metalloelastase;matrix metalloproteinase 12 (macrophage elastase)
Recombinant Proteins
- Human
- Mouse
- Rat
- Rabbit
- E.coli
- Mammalian Cells
- Human Cells
- HEK293
- Mouse myeloma cell
- Wheat Germ
- In Vitro Cell Free System
- His
- Non
- Avi&Fc&His
- Flag
- GST
Involved Pathway
MMP12 involved in several pathways and played different roles in them. We selected most pathways MMP12 participated on our site, such as Collagen degradation,Degradation of the extracellular matrix,Extracellular matrix organization, which may be useful for your reference. Also, other proteins which involved in the same pathway with MMP12 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Degradation of the extracellular matrix | MGC174152,BMP1B,MMP11,LOC100686744,TPSAB1,MMP8,TLL1,MMP24,ELANE,ACAN |
| Collagen degradation | COL15A1B,LOC100686744,ADAM10,CTS7,ELANE,MMP13,CTSL1,MMP8,MGC174152,MMP19 |
| Matrix Metalloproteinases | MMP15,MMP23B,TIMP4,MMP10,MMP8,MMP26,MMP27,MMP28,MMP24,TIMP2 |
| Extracellular matrix organization | PCOLCE,MFAP1,COL15A1B,JAM2B,DMD,ADAMTS4,TIMP2,COL5A2,COL28A1A,LRP4 |
Protein Function
MMP12 has several biochemical functions, for example, calcium ion binding,endopeptidase activity,metalloendopeptidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MMP12 itself. We selected most functions MMP12 had, and list some proteins which have the same functions with MMP12. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | NEURL1B,RING1,CXXC4,POLE,HE1B,TAB2,PRICKLE1A,CXXC1A,CBLL1,ADAMTS10 |
| calcium ion binding | ENPP2,PPEF1,EFCAB7,CIB3,SYT10,EHD2,ADAMTS13,ELTD1,BMP1,PCDHB13 |
| endopeptidase activity | TPP2,PCSK6,SENP3A,PSMB7,CASP1,PSEN2,PSMB5,MMP9,SENP5,ADAMTS3 |
| metalloendopeptidase activity | MMP30,MMP7,PHEX,ECE1,NPSN,ADAMTS12,UQCRC1,ADAMTS8,ADAMTSL5,MEP1B |
Interacting Protein
MMP12 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MMP12 here. Most of them are supplied by our site. Hope this information will be useful for your research of MMP12.
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References
- Palacios, BS; Estrada-Capetillo, L; et al. Macrophages from the synovium of active rheumatoid arthritis exhibit an activin A-dependent pro-inflammatory profile. JOURNAL OF PATHOLOGY 235:515-526(2015).
- John-Schuster, G; Hager, K; et al. Cigarette smoke-induced iBALT mediates macrophage activation in a B cell-dependent manner in COPD. AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY 307:L692-L706(2014).
