Recombinant Human matrix metallopeptidase 12 Protein, Tag Free

• Cat.No.: MMP12-037H
• Product Overview: The sequence (Accession # NP_002417) corresponding to the catalytic domain (aa 106-267) of Human MMP-12 was expressed in E. coli. The recombinant human MMP-12 was purified from bacterial lysate and refolded using proprietary technique.

Specification

• Species: Human
• Source: E.coli
• Tag: Non
• Protein Length: 106-267aa
• Description: This gene encodes a member of the peptidase M10 family of matrix metalloproteinases (MMPs). Proteins in this family are involved in the breakdown of extracellular matrix in normal physiological processes, such as embryonic development, reproduction, and tissue remodeling, as well as in disease processes, such as arthritis and metastasis. The encoded preproprotein is proteolytically processed to generate the mature protease. This protease degrades soluble and insoluble elastin. This gene may play a role in aneurysm formation and mutations in this gene are associated with lung function and chronic obstructive pulmonary disease (COPD). This gene is part of a cluster of MMP genes on chromosome 11.
• Tag: Non
• Form: Solution
• Molecular Mass: 18 kDa
• Purity: ≥95% by SDS-PAGE
• Applications: Protease activity
• Usage: Research use
• Storage: Store at -80 centigrade. Avoid repeated freeze-thaw cycles.
• Storage Buffer: 150 mM NaCl, 20 mM Tris-HCl, 10 mM CaCl2, 1 μM ZnCl2, pH=7.5
• References: 1. Woessner, J. et al. J. Biol. Chem. 263 (1988): 16918-16925
  2. Woessner, J. FASEB J. 5 (1991): 2145-2154
  3. Hautamaki, D. et al. Science 277 (1997): 2002-2004
  4. Dong, Z. et al. Cell 88 (1997): 801-810

Gene Information

• Gene Name: MMP12 matrix metallopeptidase 12 (macrophage elastase) [ Homo sapiens (human) ]
• Official Symbol: MMP12
• Synonyms: MMP12; matrix metallopeptidase 12 (macrophage elastase); matrix metalloproteinase 12 (macrophage elastase); macrophage metalloelastase; HME; macrophage elastase; matrix metalloproteinase-12; ME; MME; MMP-12; MGC138506
• Gene ID: 4321
• mRNA Refseq: NM_002426
• Protein Refseq: NP_002417
• MIM: 601046
• UniProt ID: P39900