MDM2
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Official Full Name
MDM2 oncogene, E3 ubiquitin protein ligase -
Overview
This gene encodes a nuclear-localized E3 ubiquitin ligase. The encoded protein can promote tumor formation by targeting tumor suppressor proteins, such as p53, for proteasomal degradation. This gene is itself transcriptionally-regulated by p53. Overexpression or amplification of this locus is detected in a variety of different cancers. There is a pseudogene for this gene on chromosome 2. Alternative splicing results in a multitude of transcript variants, many of which may be expressed only in tumor cells. [provided by RefSeq, Jun 2013] -
Synonyms
MDM2;MDM2 oncogene, E3 ubiquitin protein ligase;HDMX;hdm2;ACTFS;E3 ubiquitin-protein ligase Mdm2;oncoprotein Mdm2;Mdm2, p53 E3 ubiquitin protein ligase homolog;double minute 2, human homolog of;p53-binding protein;Mdm2, transformed 3T3 cell double minute 2, p53 binding protein
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Mouse
- E.coli
- Human
- Wheat Germ
- Mammalian Cells
- Insect Cells
- Yeast
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- HA&His&SUMO
- His&T7
- Avi&Fc&His
Involved Pathway
MDM2 involved in several pathways and played different roles in them. We selected most pathways MDM2 participated on our site, such as FoxO signaling pathway,Cell cycle,p signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with MDM2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chronic myeloid leukemia | PIK3R3,PIK3CG,NRAS,TGFB1,PTPN11,PIK3CB,STAT5A,CDK6,SHC2,SHC4 |
| Glioma | MAPK1,SHC1,SOS1,SHC3,PDGFA,CALM2,GRB2,ARAF,PIK3CD,MAP2K2 |
| Proteoglycans in cancer | FLNA,FAS,WNT7B,FZD3,PTPN6,MAPK1,WNT4,TLR2,HGF,RAC1 |
| Cell cycle | SMAD3A,TUBG2,CDK4,RAD17,CCND3,ANAPC7,GINS1,UIMC1,SMAD3B,SMC1AL |
| Thyroid hormone signaling pathway | PLCG2,MAP2K2,RXRB,SLCO1C1,RCAN1,ATP1A4,TBC1D4,SLC16A2,AKT2,PLCB4 |
| Ubiquitin mediated proteolysis | HERC4,KLHL9,WWP2,UBE4B,CUL5,UBOX5,SOCS3,ERCC8,ANAPC4,UBE3B |
| Prostate Cancer | GRB2,PIK3CD,PTEN,PDGFRA,HRAS,LEF1,CCNE1,NRAS,PIK3R3,NFKB1 |
| Melanoma | FGF3,BRAF,HRAS,FGF10,MAP2K2,Pdgfa&Pdgfb,FGF18,PIK3R5,Fgf15,FGF8 |
| Epstein-Barr virus infection | YWHAZ,EIF2AK1,YWHAB,IRAK1,PSMD1,SKP2,CD38,EIF2AK4,NFKBIE,HLA-DQA1 |
Protein Function
MDM2 has several biochemical functions, for example, enzyme binding,identical protein binding,ligase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by MDM2 itself. We selected most functions MDM2 had, and list some proteins which have the same functions with MDM2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| zinc ion binding | CAHZ,SERPINB1A,FANCL,ADH7,ADAM2,ZFAND1,RARGB,RNF11B,BTR29,CIZ1B |
| protein binding | FER,LRRC47,AP5Z1,SEMA4D,DUSP23,VPS45,Unc5b,ZNF223,RSPH3,SCYL1 |
| scaffold protein binding | CHUK,GRIN2A,CACNA1G,DSP,NLGN4X,CIT,TREM1,PARK7,NLGN1,SHANK3 |
| enzyme binding | KALRN,U2AF2,MTA1,Ar,LGALS9,AXIN2,C2orf56,MSH2,KPNB1,MARCH6 |
| identical protein binding | GPR50,MAP3K11,AHI1,NCAM1,SDK2,NISCH,ATXN10,SIAH1A,DRG1,APIP |
| ubiquitin protein ligase activity | TRIM2,UBR1,SIAH2L,RNF34,UBE2NA,MSL2B,BTRC,TRIM59,UBE2A,RNF24 |
| p53 binding | MAPKAPK5,TRP53,TRP63,TAF1,SMYD2,GSK3B,NTRK3,SMARCA4,NUAK1,ZMAT4 |
| ubiquitin-protein transferase activity | RNF31,BIRC5,XIAP,BIRC2,TRIM27,FBXO4,UBE2D2,FBXO22,UBE2N,MARCH6 |
| ubiquitin protein ligase binding | PIAS1,UBE2S,CASP8,MOAP1,UBE2N,RIPK1,UBXN1,ANAPC2,RB1,UCHL1 |
Interacting Protein
MDM2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with MDM2 here. Most of them are supplied by our site. Hope this information will be useful for your research of MDM2.
TP53
MDM2 Related Signal Pathway
Resources
Research Area
Cancer Drug TargetsHistone Ubiquitylation
Ubiquitin-related Molecules in the Akt Pathway
E3 Ubiquitin Ligases
p53 Pathway
Pancreatic Cancer Biomarkers
Oncoprotein-Apoptosis Regulation
Ubiquitin-Proteasome Pathway
Related Services
Related Products
References
- Ruiz, C; Li, JL; et al. Limited genomic heterogeneity of circulating melanoma cells in advanced stage patients. PHYSICAL BIOLOGY 12:-(2015).
- Herting, F; Herter, S; et al. Combination of the Glycoengineered Type II CD20 Antibody Obinutuzumab (GA101) and the MDM2 Selective Antagonist RG7388 Results in Superior Anti-Tumor Activity. BLOOD 124:-(2014).
