LIMK1
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Official Full Name
LIM domain kinase 1 -
Overview
There are approximately 40 known eukaryotic LIM proteins, so named for the LIM domains they contain. LIM domains are highly conserved cysteine-rich structures containing 2 zinc fingers. Although zinc fingers usually function by binding to DNA or RNA, the LIM motif probably mediates protein-protein interactions. LIM kinase-1 and LIM kinase-2 belong to a small subfamily with a unique combination of 2 N-terminal LIM motifs and a C-terminal protein kinase domain. LIMK1 is a serine/threonine kinase that regulates actin polymerization via phosphorylation and inactivation of the actin binding factor cofilin. This protein is ubiquitously expressed during development and plays a role in many cellular processes associated with cytoskeletal structure. This protein also stimulates axon growth and may play a role in brain development. LIMK1 hemizygosity is implicated in the impaired visuospatial constructive cognition of Williams syndrome. Alternative splicing results in multiple transcript variants encoding distinct isoforms.[provided by RefSeq, Feb 2011] -
Synonyms
LIMK1;LIM domain kinase 1;LIMK;LIMK-1;LIM motif-containing protein kinase
Recombinant Proteins
- Human
- Chicken
- Mouse
- Sf9 Insect Cell
- Wheat Germ
- Mammalian Cell
- HEK293
- Insect Cell
- HEK293T
- In Vitro Cell Free System
- GST
- Non
- His
- Myc&DDK
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| LIMK1-1029H |
Active Recombinant Human LIMK1, GST-tagged
|
Sf9 Insect Cell | Human | GST | 285-638 a.a. |
|
| LIMK1-1542H |
Active Recombinant human LIMK1, GST-tagged
|
Sf9 Insect Cell | Human | GST | 285-638 a.a. |
|
| LIMK1-131H | Recombinant Human LIMK1, GST-tagged | Sf9 Insect Cell | Human | GST | 285-638 a.a. |
|
| LIMK1-29945TH | Recombinant Human LIMK1 | Human | Non | 285-638 a.a. |
|
|
| LIMK1-321H | Recombinant Human LIMK1 protein, GST-tagged | Wheat Germ | Human | GST | 1-647 a.a. |
|
| LIMK1-531H | Recombinant Human LIMK1 | Mammalian Cell | Human | His |
|
|
| LIMK1-5707C | Recombinant Chicken LIMK1 | Mammalian Cell | Chicken | His |
|
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| LIMK1-9108M | Recombinant Mouse LIMK1 Protein | Mammalian Cell | Mouse | His |
|
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| LIMK1-4739HCL | Recombinant Human LIMK1 293 Cell Lysate | HEK293 | Human | Non |
|
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| LIMK1-1176H | Recombinant Human LIMK1 Protein (R329-G638), Tag Free | Insect Cell | Human | Non | R329-G638 |
|
| LIMK1-1177H | Recombinant Human LIMK1 Protein (R329-G638), His tagged | Insect Cell | Human | His | R329-G638 |
|
| Limk1-1320M | Recombinant Mouse Limk1 Protein, MYC/DDK-tagged | HEK293T | Mouse | Myc&DDK |
|
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| LIMK1-3693H | Recombinant Human LIMK1 Protein, Myc/DDK-tagged, C13 and N15-labeled | HEK293T | Human | Myc&DDK |
|
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| LIMK1-39H | Recombinant Human LIMK1 Protein (285-638), N-GST tagged | Sf9 Insect Cell | Human | GST | 285-638 |
|
| LIMK1-5085M | Recombinant Mouse LIMK1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
|
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| LIMK1-5085M-B | Recombinant Mouse LIMK1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
|
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| LIMK1-675HF | Recombinant Full Length Human LIMK1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 647 amino acids |
|
Involved Pathway
LIMK1 involved in several pathways and played different roles in them. We selected most pathways LIMK1 participated on our site, such as Axon guidance,Fc gamma R-mediated phagocytosis,Regulation of actin cytoskeleton, which may be useful for your reference. Also, other proteins which involved in the same pathway with LIMK1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Regulation of Actin Cytoskeleton | ROCK1,RDX,SRC,SCINLB,PTK2AA,FN1,PIP5K1AB,ITGA3B,EZR,FGF4 |
| Fc gamma R-mediated phagocytosis | PRKCD,PIK3CG,CDC42,RAC2,PRKCE,ASAP2,RPS6KB2,PIK3R1,SPHK1,MYO10 |
| Axon guidance | ARPC2,SPTBN1,CDC42,GFRA4,RGS3,Ntng2,NRP1,AP2A2,DPYSL4,DPYSL5B |
Protein Function
LIMK1 has several biochemical functions, for example, ATP binding,heat shock protein binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by LIMK1 itself. We selected most functions LIMK1 had, and list some proteins which have the same functions with LIMK1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | SSR1,RAP2B,CNOT3,PTK2,GADD45A,FBLIM1,FAM195A,EFEMP2,HRASLS5,SIPA1L2 |
| protein serine/threonine kinase activity | NEK3,SNRK,OXSR1A,STK17B,OXSR1B,PRKCA,SLC14A2,MAPK4,GRK5,ERN2 |
| ATP binding | FGFR1A,ITGB1BP3,FGFR3,CLCN6,NLRP10,MLH3,UBE2J1,MYHC4,CDK20,HK3 |
| protein kinase activity | MAP2K2B,DYRK3,SLKA,CAMK2D1,MAP2K4,JAK2,CDK11A,CSNK1D,ACVR2AA,NRBP2 |
| heat shock protein binding | PPP5C,HSPA6,TOMM34,CDC37,IRAK1,SSUH2RS1,PARK2,DLST,DNAJA4,GPR37 |
| zinc ion binding | ADAM20,CA12,RABGGTB,RNF180,NR5A1B,TRIM24,MMP30,MID2,Npepo,RLIM |
| protein heterodimerization activity | TIMELESS,HIST1H2BH,H2-AB1,ITGB1,TAF13,BAXB,TAF4B,AXL,TCF3,HIST1H2BM |
Interacting Protein
LIMK1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with LIMK1 here. Most of them are supplied by our site. Hope this information will be useful for your research of LIMK1.
SSH1;PAK1;LATS1;PAK2;Arrb1
LIMK1 Related Signal Pathway
Resources
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References
- Li, S; Leshchyns'ka, I; et al. The Neural Cell Adhesion Molecule (NCAM) Associates with and Signals through p21-Activated Kinase 1 (Pak1). JOURNAL OF NEUROSCIENCE 33:790-+(2013).
- Davies, AH; Barrett, I; et al. YB-1 evokes susceptibility to cancer through cytokinesis failure, mitotic dysfunction and HER2 amplification. ONCOGENE 30:3649-3660(2011).
