Recombinant Human LIMK1 Protein (R329-G638), His tagged

Cat.No. : LIMK1-1177H
Product Overview : Recombinant Human 8His-TEV-LIMK1(R329-G638) (D460N) Protein was expressed in Insect cell.
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Species : Human
Source : Insect Cells
Tag : His
Protein Length : R329-G638
Description : Serine/threonine-protein kinase that plays an essential role in the regulation of actin filament dynamics. Acts downstream of several Rho family GTPase signal transduction pathways. Activated by upstream kinases including ROCK1, PAK1 and PAK4, which phosphorylate LIMK1 on a threonine residue located in its activation loop. LIMK1 subsequently phosphorylates and inactivates the actin binding/depolymerizing factors cofilin-1/CFL1, cofilin-2/CFL2 and destrin/DSTN, thereby preventing the cleavage of filamentous actin (F-actin), and stabilizing the actin cytoskeleton. In this way LIMK1 regulates several actin-dependent biological processes including cell motility, cell cycle progression, and differentiation. Phosphorylates TPPP on serine residues, thereby promoting microtubule disassembly. Stimulates axonal outgrowth and may be involved in brain development.
Form : Liquid
Endotoxin : < 0.01 EU per μg of the protein
Purity : 90%
Stability : Samples are stable for up to twelve months from date of receipt at -20 to -80 centigrade.
Storage : Store it under sterile conditions at -20 to -80 centigrade. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
Storage Buffer : Supplied as sterile 50mM Tris-HCl (pH 7.5), 200mM NaCl, 20% glycerol
Shipping : It is shipped out with blue ice.
Gene Name LIMK1 LIM domain kinase 1 [ Homo sapiens (human) ]
Official Symbol LIMK1
Synonyms LIMK1; LIM domain kinase 1; LIMK; LIM motif-containing protein kinase; LIMK-1;
Gene ID 3984
mRNA Refseq NM_001204426
Protein Refseq NP_001191355
MIM 601329
UniProt ID P53667

Not For Human Consumption!

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