IL6R
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Official Full Name
interleukin 6 receptor -
Overview
his gene encodes a subunit of the interleukin 6 (IL6) receptor complex. Interleukin 6 is a potent pleiotropic cytokine that regulates cell growth and differentiation and plays an important role in the immune response. The IL6 receptor is a protein complex consisting of this protein and interleukin 6 signal transducer (IL6ST/GP130/IL6-beta), a receptor subunit also shared by many other cytokines. Dysregulated production of IL6 and this receptor are implicated in the pathogenesis of many diseases, such as multiple myeloma, autoimmune diseases and prostate cancer. Alternatively spliced transcript variants encoding distinct isoforms have been reported. A pseudogene of this gene is found on chromosome 9. -
Synonyms
IL6Q;gp80;CD126;IL6RA;IL6RQ;IL-6RA;IL-6R-1;interleukin 6 receptor;IL6R
Recombinant Proteins
- Human
- Macaca mulatta
- Canine
- Rat
- Rhesus macaque
- Zebrafish
- Mouse
- Sus scrofa (Pig)
- HEK293
- CHO
- Mammalian Cells
- E.coli
- Human
- Human Cells
- Sf9 Cells
- Wheat Germ
- Yeast
- In Vitro Cell Free System
- His
- Avi&His
- Fc
- Non
- hIgG4
- Avi&Fc
- DDK&Myc
- Avi&Fc&His
- GST
Involved Pathway
IL6R involved in several pathways and played different roles in them. We selected most pathways IL6R participated on our site, such as Cytokine-cytokine receptor interaction,HIF- signaling pathway,PIK-Akt signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL6R were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| PIK-Akt signaling pathway | FGF18,VEGFA,IFNA5,FGF1,Kitl,OSM,GNG7,RAC1,PPP2R2C,RAF1 |
| Hematopoietic cell lineage | IL1A,KIT,IL3RA,ITGA2,GM-CSF,IL6,Cd24a,Fcer2a,IL1R2,GYPA |
| Jak-STAT signaling pathway | Ifnl2,TSLP,TP-1,STAM2,CSH,EPOR,OSMR,GM13305,IFNE,EP300 |
| HIF- signaling pathway | MTOR,MAP2K1,CAMK2A,SLC2A1,VHL,EP300,NFKB1,MAP2K2,CAMK2D,HK1 |
| Cytokine-cytokine receptor interaction | IL22RA1,TNFRSF10A,IL-15RA,CSF2RB,IL12BA,IFNA17,CCL3L3,XCR1,TGFB2,CCL17 |
| Non-alcoholic fatty liver disease (NAFLD) | MAP3K11,NDUFV3,PRKAB2,UQCRQ,SDHA,NDUFA4L2,IKBKB,NDUFB10,PRKAG1,Casp3 |
Protein Function
IL6R has several biochemical functions, for example, ciliary neurotrophic factor binding,contributes_to ciliary neurotrophic factor receptor activity,enzyme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL6R itself. We selected most functions IL6R had, and list some proteins which have the same functions with IL6R. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | MFF,PEX11B,NR6A1,APOC2,TENM3,HNF1A,FLNA,TBX18,ZFP423,TKT |
| protein binding | FANCM,RBM17,NRBP1,EEF1D,HOOK2,ENC1,SMARCC2,FBXO3,NAA35,C1orf182 |
| contributes_to interleukin-6 receptor binding | Il6ra,IL6,IL6ST |
| enzyme binding | KDM1A,JUND,PYCARD,WWOX,NCOA1,LDB1,GOT2,PPARG,PDE4DIP,RPS3 |
| ciliary neurotrophic factor binding | Il6ra |
| interleukin-6 binding | Il6ra |
| contributes_to ciliary neurotrophic factor receptor activity | LIFR,Il6ra,CNTFR |
| contributes_to interleukin-6 receptor activity | IL6ST,Il6ra |
Interacting Protein
IL6R has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL6R here. Most of them are supplied by our site. Hope this information will be useful for your research of IL6R.
IL6;K2;JAK1;ERAP1;Adam17;IL6ST
IL6R Related Signal Pathway
Resources
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References
- Tseng-Rogenski, SS; Hamaya, Y; et al. Interleukin 6 Alters Localization of hMSH3, Leading to DNA Mismatch Repair Defects in Colorectal Cancer Cells. GASTROENTEROLOGY 148:579-589(2015).
- Kim, G; Ouzounova, M; et al. SOCS3-mediated regulation of inflammatory cytokines in PTEN and p53 inactivated triple negative breast cancer model. ONCOGENE 34:671-680(2015).
