Recombinant Human Interleukin 6 Receptor, His-tagged

• Cat.No.: IL6R-1241H
• Product Overview: Recombinant humanIL6R is a single, non-glycosylated polypeptide chain containing 338 aminoacids (aa 20-357) corresponding to the mature IL6R protein with an aminoterminal hexahistidine tag.

Specification

• Species: Human
• Source: E.coli
• Tag: His
• Protein Length: 20-357 a.a.
• Description: The IL6R complex is composed of two membrane glycoproteins: thelow affinity receptor and the signaltransducing component. The soluble formof IL6R is found in the urine of healthy adult humans and the serum of HIVpositive individuals, as well as in the cell culture supernatants ofstimulated PBMC's. This soluble form of IL6R results from either proteolyticcleavage from the membrane, or an isoform derived splice variant.
• Form: Liquid in 20 mM TrisHCl pH 8 + 50% glycerol.
• MolecularWeight: 42.25 kDa
• Purity: > 95% by SDS-PAGEand HPLC analyses
• Endotoxin Level: <0.1 ng/µg of IL6R
• Storage: Store at 2-4°C ifentire vial will be used within 2-4 weeks. Store, frozen at -20°C for longerperiods of time. Avoid repeated freeze-thaw cycles.
• OfficialSymbol: IL6R

Gene Information

• Gene Name: IL6R interleukin 6 receptor [ Homosapiens ]
• Synonyms: IL6R; interleukin 6 receptor; CD126; IL-6R-1; IL6R-alpha; IL-6R-alpha; IL6RA;MGC104991; OTTHUMP00000034320; gp80; CD126 antigen; IL-6R 1; Interleukin-6receptor alpha chain precursor; B cell stimulatory factor-2; Membraneglycoprotein 80; interleukin 6 receptor; interleukin 6 receptor alpha subunit
• Gene ID: 3570
• mRNA Refseq: NM_000565
• Protein Refseq: NP_000556
• MIM: 147880
• UniProt ID: P08887
• Chromosome Location: 1q21
• Pathway: Cytokine-cytokine receptorinteraction; Hematopoietic cell lineage; Jak-STAT signaling pathway
• Function: ciliary neurotrophic factorbinding; ciliary neurotrophic factor receptor activity;enzyme binding;interleukin-6 receptor activity; protein homodimerization activity; receptorbinding