IL1R1
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Official Full Name
interleukin 1 receptor, type I -
Overview
Tumor Necrosis Factor Receptor Type I (TNFRI); is a 55kD Type I transmembrane protein. TNFRI is expressed independently of TNFRII at low levels on a wide variety of cell types. TNFRI binds TNF-alpha and TNF-beta; (also known as LT-alpha );. The subsequen -
Synonyms
IL1R1;interleukin 1 receptor, type I;IL1R, IL1RA;interleukin-1 receptor type 1;CD121A;D2S1473;IL-1R-1;IL-1RT1;IL-1RT-1;antigen CD121a;interleukin receptor 1;interleukin-1 receptor alpha;interleukin-1 receptor type I;CD121 antigen-like family
Recombinant Proteins
- Rat
- Human
- Cynomolgus
- Mouse
- Chicken
- Mus musculus
- HEK293
- Human Cells
- E.coli
- Insect Cells
- CHO
- S.frugiperda
- Mammalian Cells
- His
- Fc
- Fc&His
- Non
- Flag
- His&T7
- Avi&Fc&His
- GST
- His&Myc&SUMO
- His&Myc
Involved Pathway
IL1R1 involved in several pathways and played different roles in them. We selected most pathways IL1R1 participated on our site, such as MAPK signaling pathway,Cytokine-cytokine receptor interaction,NF-kappa B signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with IL1R1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HTLV-I infection | FZD8,IL2RG,RELB,POLD4,TGFB2,DLG1,SMAD4,MAP3K14,NFKB1,HLA-E |
| Hematopoietic cell lineage | CD1d1,CD1D,CD34,IL5RA,IL6R,CD3E,IL9R,GP5,Fcer2a,CD3G |
| Amoebiasis | SERPINB3C,TGFB2,LAMA3,COL4A1,SERPINB9,GNA15,ITGB2L,VCL,COL4A6,ACTN3 |
| NF-kappa B signaling pathway | CCL4L1,UBE2I,CXCL2,LTBR,ICAM1,TICAM2,TRAF5,RELB,PRKCB,Ccl21c |
| Cytokine-cytokine receptor interaction | IFNAR1,ACVR2A,IL6R,GM2506,INHBC,ACVR1B,CXCL11,IL5,IFNA13,ACVR1 |
| Osteoclast differentiation | TGFB1,PPP3CA,PPARG,MAPK3,FCGR2C,LCP2,MAPK12,FOSB,MITF,PIK3R1 |
| MAPK signaling pathway | FGF13A,PAK2B,NRAS,FGF6,PPP3R1,GRB2,SOS1,MOS,PRKACAB,IL1A |
| Inflammatory mediator regulation of TRP channels | PIK3CA,CYP4A12A,PLCB1,TRPV4,PLA2G4D,PRKACA,TRPA1,HRH1,ACCN3,PRKCG |
| Apoptosis | TNFRSF1A,NFKBIAA,PRKAR1A,PRKACG,BIDA,DYNLL2,BCL2A,CLSPN,IL1B,PPP3CB |
Protein Function
IL1R1 has several biochemical functions, for example, interleukin-1 receptor activity,interleukin-1, Type I, activating receptor activity,ionotropic glutamate receptor binding. Some of the functions are cooperated with other proteins, some of the functions could acted by IL1R1 itself. We selected most functions IL1R1 had, and list some proteins which have the same functions with IL1R1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transmembrane signaling receptor activity | OR6K3,CR2,CD3D,NPR2,NRXN2,LILRA1,CD300C,CD72,GP6,OR4F29 |
| interleukin-1, Type I, activating receptor activity | IL1RL2 |
| platelet-derived growth factor receptor binding | Pdgfa&Pdgfb,VEGFA,PTEN,PDGFRA,ITGB3,PDGFRB,PTPRJ,PDGFB,TYMP,PDGFD |
| ionotropic glutamate receptor binding | DLG1,GNAS,RAB4A,NETO1,CANX,DLG4,SHANK1,DLG4B,ADRB2,FLOT2 |
| interleukin-1 receptor activity | IL18R1,IL1RAPL1A,IL1RAPL2,IL1RL2,IL1RAP,IL1R2,IL1RL1 |
| signal transducer activity | TAS2R109,OLFCD2,TFG,CC2D1A,HMOX1,CHRM2A,OPRD1B,SECTM1,PLCD4,EDNRAA |
| protease binding | SERPINE1,F3,A2M,BCL2,TIMP4,CRADD,NFRKB,Casp3,ECM1,CHL1 |
| protein binding | FZR1,HSPB9,MED20,MTMR7,ZNF695,HOPX,RGS6,SNTA1,PDE4D,CCBE1 |
Interacting Protein
IL1R1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with IL1R1 here. Most of them are supplied by our site. Hope this information will be useful for your research of IL1R1.
TRAF6;IL1B;IL1RN;TICAM2;IL1RAP;MAP3K14
IL1R1 Related Signal Pathway
Resources
Research Area
NeuroinflammationEndothelial Cell Markers
Cytokine and Growth Factor Receptors on VSMC
Natural Killer T (NKT) Cells
T Cell Cytokine Signaling
Other Dendritic Cell CD Antigen
CD Antigen (Helper T Cells)
Rheumatoid arthritis Therapeutic Targets
NOD-like Receptors and the Inflammasome
Th17 Cells
IL-1 Family Receptors
MDSC Phenotyping - Positive Markers
Related Services
Related Products
References
- Suwara, MI; Green, NJ; et al. IL-1 alpha released from damaged epithelial cells is sufficient and essential to trigger inflammatory responses in human lung fibroblasts. MUCOSAL IMMUNOLOGY 7:684-693(2014).
- Britze, A; Palmfeldt, J; et al. 44-plex cytokine profile of cholesteatoma. ACTA OTO-LARYNGOLOGICA 134:41-50(2014).
