Active Recombinant Mouse Interleukin 1 Receptor, Type I, His-tagged

• Cat.No.: Il1r1-5652M
• Product Overview: RecombinantMouse Il1r1 protein was expressed in Murine myeloma cellline.Asp22-Arg338 (Ala158Val), with a C-terminal 6-His tag.

Specification

• Species: Mouse
• Source: Mammalian Cells
• Tag: His
• Protein Length: 22-338 a.a.
• Description: Il1r1 isa member of the IL-1 R/TLR superfamily. Members of this superfamily have a characteristicToll-IL-1 R (TIR) domain in their cytoplasmic region. This superfamily can befurther divided into three subgroups based on extracellular region analogies.Il1r1 belongs to Subgroup 1 which is characterized by the presence of atleast one immunoglobulin-like domain. Mouse Il1r1 is a 70 kDa type I transmembraneglycoprotein that is synthesized as a 574 amino acid (aa) precursor. Theprecursor contains a 21 aa signal sequence, a 317 aa extracellular region, a21 aa transmembrane segment, and a 215 aa cytoplasmic domain.
• Form: Lyophilizedfrom a 0.2 um filtered solution in PBS with BSA as a carrier protein.
• N-terminalSequence: Asp22
• MolecularWeight: 36.8 kDa
• Activity: Measuredby its binding ability in a functional ELISA. Immobilized rmIL-1F5, rmIL-1F6,or rmIL-1F8 at 1 μg/mL (100 μL/well) can bind rm Il1r1/his witha linear range of 0.078-5 μg/mL.
• Endotoxin Level: <1.0EU per 1μg of the protein by the LAL method.
• SDS-PAGE: 55-68kDa, reducing conditions.
• Purity: >90%,by SDS-PAGE under reducing conditions and visualized by silver stain.
• Reconstitution: 100 μg/mLin sterile PBS containing at least 0.1% human or bovine serum albumin
• Storage: Use amanual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70°C as supplied.1 month, 2 to 8°C under sterile conditions after reconstitution. 3months, -20 to -70°C under sterile conditions after reconstitution.

Gene Information

• Gene Name: Il1r1 interleukin 1 receptor,type I [ Mus musculus ]
• Official Symbol: Il1r1
• Synonyms: Il1r1; interleukin 1receptor, type I; IL-iR; CD121a;CD121b; Il1r-1; interleukin-1 receptor type 1; p80; IL-1R-1; IL-1RT1;IL-1RT-1; IL-1R-alpha; IL-1 receptor alpha chain; interleukin-1 receptoralpha; interleukin-1 receptor type I; CD121 antigen-like family member A
• Gene ID: 16177
• mRNA Refseq: NM_001123382
• Protein Refseq: NP_001116854
• UniProt ID: Q9ERS7
• Chromosome Location: 1
• Pathway: Amoebiasis;Apoptosis; Cytokine-cytokine receptor interaction; HTLV-I infection;Hematopoietic cell lineage; Hypertrophy Model; IL-1 Signaling Pathway; MAPKsignaling pathway; Osteoclast differentiation
• Function: interleukin-1receptor activity; interleukin-1, Type I, activating receptor activity;ionotropic glutamate receptor binding; platelet-derived growth factorreceptor binding; protease binding; protein binding; receptor activity;signal transducer activity; transmembrane signaling receptor activity