The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. The encoded protein may be involved in the moderation of asthma and allergic diseases. The reference genome represents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAV seropositive individuals. Three transcript variants encoding the same protein have been found for this gene. [provided by RefSeq, Mar 2010]
Synonyms
HAVCR1;hepatitis A virus cellular receptor 1;TIM;KIM1;TIM1;HAVCR;KIM-1;TIM-1;TIMD1;TIMD-1;HAVCR-1;kidney injury molecule 1;T-cell membrane protein 1;T-cell immunoglobulin mucin receptor 1;T-cell immunoglobulin mucin family member 1;T cell immunoglobin domain and mucin domain protein 1
Havcr1 involved in several pathways and played different roles in them. We selected most pathways Havcr1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Havcr1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
Pathway Name
Pathway Related Protein
Protein Function
Havcr1 has several biochemical functions, for example, virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Havcr1 itself. We selected most functions Havcr1 had, and list some proteins which have the same functions with Havcr1. You can find most of the proteins on our site.
Havcr1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Havcr1 here. Most of them are supplied by our site. Hope this information will be useful for your research of Havcr1.
Chen, F; Smith, R; et al. Toxicoepigenetic Alteration of the Kidney Injury Molecule 1 Gene in Gentamicin-Exposed Rat Kidney. TOXICOLOGICAL SCIENCES 117:375-380(2010).
Renders, L; Heemann, U; et al. Chronic renal allograft damage after transplantation: what are the reasons, what can we do?. CURRENT OPINION IN ORGAN TRANSPLANTATION 17:634-639(2012).
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