Active Recombinant Human HAVCR1, HIgG1 Fc-tagged

• Cat.No.: HAVCR1-2312H
• Product Overview: The extracellular domain of human Tim-1 (NP_036338.2) (Ser21-Gln295) is fused to the N-terminus of the Fc region of human IgG1 was expressed in CHO cell.

Specification

• Species: Human
• Source: CHO
• Tag: Fc
• Description: The protein encoded by this gene is a membrane receptor for both human hepatitis A virus (HHAV) and TIMD4. Theencoded protein may be involved in the moderation of asthma and allergic diseases. The reference genomerepresents an allele that retains a MTTVP amino acid segment that confers protection against atopy in HHAVseropositive individuals. Three transcript variants encoding the same protein have been found for this gene
• Form: Lyophilized from 0.2μm-filtered solution in PBS.
• Bio-activity: Measured by its ability to inhibit anti-CD3-induced proliferation of stimulated human T cells.
• Molecular Mass: 57 KDa (monomer)
• AA Sequence: Ser21-Gln295
• Endotoxin: <0.06 eu/μg="" as="" determined="" by="" lal="" test.="">
• Purity: >98%, by SDS-PAGE under reducing conditions
• Stability: Stable for at least 1 year after receipt when stored at -20°C. Working aliquots are stable for up to 3 months when stored at -20°C.
• Reconstitution: Reconstitute at 100μg/ml in sterile PBS.
• Warning: Avoid freeze/thaw cycles.

Gene Information

• Gene Name: HAVCR1 hepatitis A virus cellular receptor 1 [ Homo sapiens ]
• Official Symbol: HAVCR1
• Synonyms: HAVCR1; hepatitis A virus cellular receptor 1; HAVCR; HAVCR 1; TIM 1; TIM1; TIMD1; kidney injury molecule 1; T-cell membrane protein 1; T cell immunoglobin domain and mucin domain protein 1; TIM; KIM1; KIM-1; TIM-1; TIMD-1; HAVCR-1
• Gene ID: 26762
• mRNA Refseq: NM_001099414
• Protein Refseq: NP_001092884
• MIM: 606518
• UniProt ID: Q96D42
• Chromosome Location: 5q33.2
• Function: receptor activity