HNMT
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Official Full Name
histamine N-methyltransferase -
Overview
In mammals, histamine is metabolized by two major pathways: N(tau)-methylation via histamine N-methyltransferase and oxidative deamination via diamine oxidase. This gene encodes the first enzyme which is found in the cytosol and uses S-adenosyl-L-methionine as the methyl donor. In the mammalian brain, the neurotransmitter activity of histamine is controlled by N(tau)-methylation as diamine oxidase is not found in the central nervous system. A common genetic polymorphism affects the activity levels of this gene product in red blood cells. Multiple alternatively spliced transcript variants that encode different proteins have been found for this gene. -
Synonyms
HNMT;histamine N-methyltransferase;HMT;HNMT-S1;HNMT-S2
Recombinant Proteins
- Rat
- Human
- Zebrafish
- Rhesus macaque
- Chicken
- Mouse
- Rat Kidney
- E. coli
- E.coli
- Mammalian Cell
- Human
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- Non
- His
- GST
- His&Fc&Avi
- N-His&C-Myc
Involved Pathway
HNMT involved in several pathways and played different roles in them. We selected most pathways HNMT participated on our site, such as Histidine metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with HNMT were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Histidine metabolism | ALDH2.1,ALDH9A1,MAOA,CNDP2,HDC,ALDH3B1,UROC1,ASPA,ALDH3A2A,CNDP1 |
Protein Function
HNMT has several biochemical functions, for example, histamine N-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HNMT itself. We selected most functions HNMT had, and list some proteins which have the same functions with HNMT. You can find most of the proteins on our site.
| Function | Related Protein |
|---|
Interacting Protein
HNMT has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HNMT here. Most of them are supplied by our site. Hope this information will be useful for your research of HNMT.
TERF1;CAMK2D;TINF2;POT1;Tpm1
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