HIST1H2BA
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Official Full Name
histone cluster 1, H2ba -
Overview
Histones are basic nuclear proteins that are responsible for the nucleosome structure of the chromosomal fiber in eukaryotes. Nucleosomes consist of approximately 146 bp of DNA wrapped around a histone octamer composed of pairs of each of the four core histones (H2A, H2B, H3, and H4). The chromatin fiber is further compacted through the interaction of a linker histone, H1, with the DNA between the nucleosomes to form higher order chromatin structures. This gene is intronless and encodes a testis/sperm-specific member of the histone H2B family. Transcripts from this gene contain a palindromic termination element. -
Synonyms
HIST1H2BA;histone cluster 1, H2ba;H2B histone family, member U, (testis specific) , histone 1, H2ba;histone H2B type 1-A;bA317E16.3;H2BFU;STBP;TSH2B;Testis-specific histone H2B;H2B;H2B histone family member U;H2B histone family member U testis specific;H2B testis;H2BT;Histone cluster 1 H2ba;Histone H2B testis;Histone H2B type 1 A;Histone H2B type 1A;TSH 2B;histone 1, H2ba;histone H2B, testis;H2B histone family, member U, (testis-specific)
Recombinant Proteins
- Rhesus macaque
- Rat
- Human
- Mouse
- Mammalian Cell
- HEK293
- Wheat Germ
- E.coli
- In Vitro Cell Free System
- His
- Myc&DDK
- GST
- Non
- His&Fc&Avi
- His&Myc
Involved Pathway
HIST1H2BA involved in several pathways and played different roles in them. We selected most pathways HIST1H2BA participated on our site, such as Alcoholism,Viral carcinogenesis,Systemic lupus erythematosus, which may be useful for your reference. Also, other proteins which involved in the same pathway with HIST1H2BA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Alcoholism | HIST2H2BE,MAP2K1,PKIA,HIST1H2BB,HIST1H4F,HIST1H2BE,GNG2,HIST1H4I,HDAC5,H2AFV |
| Viral carcinogenesis | TRADD,H2-Q10,SNW1,TRAF2,PIK3CD,HIST1H2BF,CCNA1,VDAC3,HIST1H2BD,ACTN4 |
| Systemic lupus erythematosus | FCGR3A,HIST1H2BK,HIST1H4A,HIST1H2AA,H2BFWT,TRIM21,IFNG,C6,HIST1H4K,ACTN3 |
Protein Function
HIST1H2BA has several biochemical functions, for example, DNA binding,molecular_function,protein heterodimerization activity. Some of the functions are cooperated with other proteins, some of the functions could acted by HIST1H2BA itself. We selected most functions HIST1H2BA had, and list some proteins which have the same functions with HIST1H2BA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein heterodimerization activity | TFAP2E,SMAD4,IKZF2,HEXA,TCF12,LIFR,PIK3R1,H2-AB1,TCF3A,CUL3 |
| molecular_function | TMEM52B,KRTAP19-9B,ABI2A,Oit1,D4BWG0951E,FAM24A,SULT6B1,ZP3B,VSTM2B,CMTM4 |
| DNA binding | ETV5,HIST1H4E,CXXC1B,IFIH1,TNFAIP3,TTC5,TOP3B,HOXD13A,HOXC6A,NR6A1A |
Interacting Protein
HIST1H2BA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HIST1H2BA here. Most of them are supplied by our site. Hope this information will be useful for your research of HIST1H2BA.
BRD7;ssdna_dadt;VP35;CBX8;SFMBT1
Resources
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References
- Sun, RF; Qi, HY; et al. Dynamic expression of combinatorial replication-dependent histone variant genes during mouse spermatogenesis. GENE EXPRESSION PATTERNS 14:30-41(2014).
- Maselli, J; Hales, BF; et al. Exposure to Bleomycin, Etoposide, and Cis-Platinum Alters Rat Sperm Chromatin Integrity and Sperm Head Protein Profile. BIOLOGY OF REPRODUCTION 86:-(2012).
- Jufvas, A; Stralfors, P; et al. Histone Variants and Their Post-Translational Modifications in Primary Human Fat Cells. PLOS ONE 6:-(2011).
