HAAO
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Official Full Name
3-hydroxyanthranilate 3,4-dioxygenase -
Overview
3-Hydroxyanthranilate 3,4-dioxygenase is a monomeric cytosolic protein belonging to the family of intramolecular dioxygenases containing nonheme ferrous iron. It is widely distributed in peripheral organs, such as liver and kidney, and is also present in low amounts in the central nervous system. HAAO catalyzes the synthesis of quinolinic acid (QUIN) from 3-hydroxyanthranilic acid. QUIN is an excitotoxin whose toxicity is mediated by its ability to activate glutamate N-methyl-D-aspartate receptors. Increased cerebral levels of QUIN may participate in the pathogenesis of neurologic and inflammatory disorders. HAAO has been suggested to play a role in disorders associated with altered tissue levels of QUIN. -
Synonyms
HAAO;3-hydroxyanthranilate 3,4-dioxygenase;HAD;3-hydroxyanthranilate oxygenase;3-hydroxyanthranilic acid dioxygenase;HAO;3-HAO
Recombinant Proteins
- Human
- Rat
- Zebrafish
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- HEK293T
- Insect Cell
- Mammalian cells
- GST
- His
- Non
- His&Fc&Avi
- Myc&DDK
- His&GST
- Flag
Involved Pathway
HAAO involved in several pathways and played different roles in them. We selected most pathways HAAO participated on our site, such as Tryptophan metabolism,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with HAAO were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tryptophan metabolism | OGDHL,ALDH9A1,RNF25,TDO2B,ALDH2.1,ALDH3A2A,ASMT,AOX4,IDO1,CYP4F12 |
| Metabolic pathways | PNMT,AKR1B7,TYRP1,NANSA,MAN1A1,FAM213B,MPST,PGLS,CHDH,GUK1B |
Protein Function
HAAO has several biochemical functions, for example, 3-hydroxyanthranilate 3,4-dioxygenase activity,electron carrier activity,ferrous iron binding. Some of the functions are cooperated with other proteins, some of the functions could acted by HAAO itself. We selected most functions HAAO had, and list some proteins which have the same functions with HAAO. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | GLDC,GCDH,AOX4,GLRX,NDUFS6,SH3BGRL3,ALDH4A1,LOXL2,FDX1B,SDHD |
| protein binding | C11orf46,GPC3,ASPH,PDCD2,USP5,CSTF1,MORF4L2,RAB3IL1,LMX1A,C2orf62 |
| ferrous iron binding | ISCA1,ALKBH3,NT5E,SERPINB1A,ALKBH1,FTO,CDO1,TET2,TRR1,FECH |
Interacting Protein
HAAO has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with HAAO here. Most of them are supplied by our site. Hope this information will be useful for your research of HAAO.
GAD1;GAD1;POT1;ARHGDIA;TERF2IP
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References
- Brkic, H; Kovacevic, B; et al. Human 3-hydroxyanthranilate 3,4-dioxygenase (3HAO) dynamics and reaction, a multilevel computational study. MOLECULAR BIOSYSTEMS 11:898-907(2015).
- Seifert, J; et al. Changes in mouse liver and chicken embryo yolk sac membrane soluble proteins due to an organophosphorous insecticide (OPI) diazinon linked to several noncholinergic OPI effects in mice and chicken embryos. PESTICIDE BIOCHEMISTRY AND PHYSIOLOGY 116:74-82(2014).
