GRX2
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Official Full Name
glutaredoxin 2 -
Overview
GRX1 has a glutathione-disulfide oxidoreductase activity in the presence of nadph and glutathione reductase. reduces low molecular weight disulfides and proteins. Glutaredoxin is a glutathione (GSH)-dependent hydrogen donor for ribonucleotide reductase and also catalyzes glutathione-disulfide oxidoreduction reactions in the presence of NADPH and glutathione reductase. GRX1 is multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase (GST) activity. The disulfide bond functions as an electron carrier in the glutathione-dependent synthesis of deoxyribonucleotides by the enzyme ribonucleotide reductase. In addition, it is also involved in reducing cytosolic protein- and non-protein-disulfides in a coupled system with glutathione reductase. Required for resistance to reactive oxygen species (ROS) by directly reducing hydroperoxides and for the detoxification of ROS-mediated damage. -
Synonyms
TTR1;YDR513W;GRX2
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Involved Pathway
GRX2 involved in several pathways and played different roles in them. We selected most pathways GRX2 participated on our site, such as Metabolism,Metabolism of nucleotides,Synthesis and interconversion of nucleotide di- and triphosphates, which may be useful for your reference. Also, other proteins which involved in the same pathway with GRX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolism of nucleotides | DTYMK,AK7A,ADSS,UPP2,ADK,ADAL,AK7,PAICS,DGUOK,ADA |
| Metabolism | HIBADH,CD320,SLC25A32,ALDH9A1A.2,DPYDA.1,HAS1,FABP1B.1,CPTP,ABHD4,AWAT1 |
| Synthesis and interconversion of nucleotide di- and triphosphates | AK7A,DTYMK,AK7,AK8,GLRX |
Protein Function
GRX2 has several biochemical functions, for example, disulfide oxidoreductase activity,electron carrier activity,glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GRX2 itself. We selected most functions GRX2 had, and list some proteins which have the same functions with GRX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| electron carrier activity | CYBA,NDUFV2,NOX4,AOX3L1,ACOXL,NDUFS6,GCDHA,AOC2,SDHD,ME2 |
| glutathione transferase activity | GSTA,GSTA5,GSTM5,GSTAL,GSTT2,GSTT4,GSTT2B,GSTO1,GSTZ1,GSTT1B |
| disulfide oxidoreductase activity | TMX1,PDIA3,DNAJC10,PDIA2,COIL,TXN,TXNL1 |
| glutathione peroxidase activity | MGST1,GPX1B,GPX4A,GPX3,GSTK1,GPX5,LTC4S,MGST3,GPX2,GSTT1 |
| protein disulfide oxidoreductase activity | PTGESL,DNAJC10,TXN2,TXN,TXNL1,TXNRD1,GRXCR1,GSTK1,GLRX5,SH3BGRL3 |
Interacting Protein
GRX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GRX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GRX2.
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