Recombinant Human Glutaredoxin 2, His-tagged

• Cat.No.: GLRX2-1828H
• Product Overview: Recombinant human Glutaredoxin 2, fused to His-tag at C-terminus, was expressed in E.coli and purified by using conventional chromatography.

Specification

• Cat. No.: GLRX2-1828H
• Description: Glutaredoxin-2, as known as GRX2, multifunctional enzyme with glutathione-dependent oxidoreductase, glutathione peroxidase and glutathione S-transferase(GST) activity. This protein is localized both in the mitochondria and nucleus. It has anti-apoptotic activity by preventing cardiolipin oxidation and cytochrome c release. GRX2 exhibited 36% identity with GRX1 and had a disulfide active center containing the Cys-Ser-Tyr-Cys motif.
• Sequences of amino acids: MSAGWLDRAAGAAGAAAAAASGMESNTSSSLENLATAPVNQIQETISDNC VVIFSK TSCSYCTMAKKLFHDMNVNYKVVELDLLEYGNQFQDALYKMTGERTVPRIFVNGTF I GGATDTH RLHKEGKLLP LVHQCYLKKS KRKEFQLEHH HHHH
• Form: Liquid. In 20 mM Tris-HCl Buffer (pH 8.0) containing 0.1 mM PMSF, 10% Glycerol
• Molecular Weight: 17.0 kDa (154aa)
• Purity: > 90% by SDS - PAGE
• Concentration: 0.5 mg/ml (determined by Bradford assay)
• Storage: Can be stored at +4°C short term (1-2 weeks). For long term storage, aliquot and store at -20°C or -70°C. Avoid repeated freezing and thawing cycles.

Gene Information

• Gene Name: GLRX2 glutaredoxin 2 [ Homo sapiens ]
• Synonyms: GLRX2; GRX2; bA101E13.1; bA101E13.1; glutaredoxin 2; bA101E13.1 (GRX2 glutaredoxin (thioltransferase) 2); OTTHUMP00000033766; OTTHUMP00000033767; bA101E13.1; glutaredoxin 2.
• Gene ID: 51022
• mRNA Refseq: NM_016066
• Protein Refseq: NP_057150
• MIM: 606820
• UniProt ID: Q9NS18
• Chromosome Location: 1q31.2-q31.3
• Function: 2 iron, 2 sulfur cluster binding; arsenate reductase (glutaredoxin) activity; electron carrier activity; glutathione disulfide oxidoreductase activity; iron ion binding; metal ion binding; protein disulfide oxidoreductase activity