GPX2
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Official Full Name
glutathione peroxidase 2 (gastrointestinal) -
Overview
This gene is a member of the glutathione peroxidase family and encodes a selenium-dependent glutathione peroxidase that is one of two isoenzymes responsible for the majority of the glutathione-dependent hydrogen peroxide-reducing activity in the epithelium of the gastrointestinal tract. Studies in knockout mice indicate that mRNA expression levels respond to luminal microflora, suggesting a role of the ileal glutathione peroxidases in preventing inflammation in the GI tract. -
Synonyms
GPX2;glutathione peroxidase 2 (gastrointestinal);glutathione peroxidase 2;GSHPX GI;Gastrointestinal glutathione peroxidase;GI GPx;Glutathione peroxidase gastrointestinal;Glutathione peroxidase related protein 2;Glutathione peroxidase-gastrointestinal;Glutathione peroxidase-related protein 2;GPRP;GPRP-2;GPx 2;GPx-2;GPx-GI;GPX2_HUMAN;GSHPx 2;GSHPx-2;GSHPx-GI;gastrointestinal glutathione peroxidase 2;GI-GPx
Recombinant Proteins
- Human
- Chicken
- Mouse
- Baker's yeast
- E.coli
- Mammalian Cells
- HEK293
- His
- Non
- His&Myc
- His&Fc&Avi
Involved Pathway
GPX2 involved in several pathways and played different roles in them. We selected most pathways GPX2 participated on our site, such as Glutathione metabolism,Arachidonic acid metabolism,Thyroid hormone synthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with GPX2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Glutathione metabolism | MGST1,GSTA5,GSTA3,GSTA,GPX1A,RRM1,GPX4,GSTT1B,GPX8,GSTO2 |
| Arachidonic acid metabolism | GPX1,PLA2G16,PTGDS,CYP4F11,ALOX15,PTGES,PTGES3,PLA2G12B,GPX7,CYP2B6 |
| Thyroid hormone synthesis | PLCB3,GPX8,PRKCA,ATP1B1,GPX5,ATP1A1,TSHB,ITPR3,DUOXA2,CREB3L2 |
Protein Function
GPX2 has several biochemical functions, for example, electron carrier activity,glutathione peroxidase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by GPX2 itself. We selected most functions GPX2 had, and list some proteins which have the same functions with GPX2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| glutathione peroxidase activity | GPX4A,GPX3,LTC4S,MGST2,GRX2,GSTZ1,GSTT1,GSTK1,GPX5,GPX8 |
| electron carrier activity | GCDHA,ACOX2,AKR7A3,DHDH,GLDC,IDO1,PHGDH,SDHD,CYBA,LOXL2 |
Interacting Protein
GPX2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GPX2 here. Most of them are supplied by our site. Hope this information will be useful for your research of GPX2.
MYC;TP53;PSMB2
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References
- Bajak, E; Fabbri, M; et al. Changes in Caco-2 cells transcriptome profiles upon exposure to gold nanoparticles. TOXICOLOGY LETTERS 233:187-199(2015).
- van den Berg, L; Koelsch, BU; et al. Genetic dissection of the Mss4 locus mediating sex-biased cancer resistance in the rat peripheral nervous system. INTERNATIONAL JOURNAL OF CANCER 136:2099-2108(2015).
