GDF7
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Official Full Name
growth differentiation factor 7 -
Overview
This gene encodes a member of the bone morphogenetic protein (BMP) family. BMPs belong to the transforming growth factor-beta superfamily of secreted signalling molecules that regulate diverse processes in growth, repair and embryonic development. In mouse, this gene functions as an inductive signal from the roof plate required for the specification of neuronal identity in the dorsal spinal cord. -
Synonyms
GDF7;growth differentiation factor 7;growth/differentiation factor 7;BMP12;bone morphogenetic protein 12;GDF-7;GDF7_HUMAN;OTTHUMP00000115986
Recombinant Proteins
- Human
- Mouse
- Rat
- E.coli
- Mammalian Cell
- HEK293
- Wheat Germ
- Non
- His
- His&Fc&Avi
- GST
Involved Pathway
GDF7 involved in several pathways and played different roles in them. We selected most pathways GDF7 participated on our site, such as Hippo signaling pathway,TGF-beta signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with GDF7 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Hippo signaling pathway | SCRIB,WNT5A,BMP4,FZD1,WNT5B,TP73,PRKCI,PPP2CA,FZD5,PPP2R2C |
| TGF-beta signaling pathway | INHBC,BMPR2A,TGFBR2,PPP2CB,PPP2CA,SPAW,RBL1,NOG2,SMURF2,BAMBI |
Protein Function
GDF7 has several biochemical functions, for example, cytokine activity,growth factor activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by GDF7 itself. We selected most functions GDF7 had, and list some proteins which have the same functions with GDF7. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | FGF2,PEA15,SKA1,SPRYD7,BIRC2,LRRC4C,DERL2,TNIP1,CTIF,EIF2B4 |
| transforming growth factor beta receptor binding | LEFTY2,TGFBRAP1,BMP7,LEFTY1,BMP2,GDF6B,GDF3,TGFB1A,FKBP1A,INHBAB |
| cytokine activity | VEGFA,IL36B,FAM3D,IFNA7,Ifnz,TNFSF15,GM13289,CMTM1,Il1f9,IFN-a |
| growth factor activity | PDGFA,GDF9,VEGFA,Artn,VEGFC,FGF17,NOV,INHBAB,INHBC,MDK |
| protein homodimerization activity | CADM2A,GNPTG,DMRTC1C2,VPS25,PLCB1,NOG,SP1,GSTM1,KIAA0947,CDA |
Interacting Protein
GDF7 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with GDF7 here. Most of them are supplied by our site. Hope this information will be useful for your research of GDF7.
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References
- Bakdash, G; Vogelpoel, LTC; et al. Retinoic acid primes human dendritic cells to induce gut-homing, IL-10-producing regulatory T cells. MUCOSAL IMMUNOLOGY 8:265-278(2015).
- Wendroth, SM; Mentrikoski, MJ; et al. GATA3 expression in morphologic subtypes of breast carcinoma: a comparison with gross cystic disease fluid protein 15 and mammaglobin. ANNALS OF DIAGNOSTIC PATHOLOGY 19:6-9(2015).
