Fto
-
Official Full Name
fat mass and obesity associated -
Overview
The fat mass and obesity-associated gene (FTO) gene was first described as one of several genes deleted during insertional mutagenesis in the Fused toes (Ft) mouse mutation. Now known as the fat mass and obesity-associated gene, it is abundantly expressed in most organs. The gene product is an AlkB-like DNA/RNA demethylase with a strong preference for single-stranded DNA and RNA. Single nucleotide polymorphisms (SNPs) in the first intron of the FTO gene contribute to childhood obesity and severe adult obesity. Knockout or loss-of-function of FTO produces an autosomal-recessive lethal syndrome with multiple malformations and severe growth retardation. FTO is the first locus unequivocally associated with adiposity, with activity within the central nervous system apparently regulating feeding behavior and energy expenditure. -
Synonyms
FTO;fat mass and obesity associated;ALKBH9;MGC5149;alpha-ketoglutarate-dependent dioxygenase FTO;protein fto;AlkB homolog 9;fat mass and obesity-associated protein<br/>
Recombinant Proteins
- Human
- Mouse
- Rat
- Chicken
- E.coli
- Wheat Germ
- Mammalian Cell
- Baculovirus-Insect cells
- Baculovirus
- In Vitro Cell Free System
- HEK293
- Mammalian cells
- HEK293T
- GST
- His
- Flag
- Non
- Myc&DDK
- His&Fc&Avi
- His&Myc
Involved Pathway
Fto involved in several pathways and played different roles in them. We selected most pathways Fto participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with Fto were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
Fto has several biochemical functions, for example, DNA-N1-methyladenine dioxygenase activity,ferrous iron binding,oxidative DNA demethylase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Fto itself. We selected most functions Fto had, and list some proteins which have the same functions with Fto. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidative RNA demethylase activity | ALKBH5 |
| DNA-N1-methyladenine dioxygenase activity | KDM5BB,JMJD1C,PHF2,ALKBH3,ALKBH2,KDM5D |
| ferrous iron binding | ACP5,ISCUB,NT5E,ISCA1,CDO1,SNCA,SERPINB1A,ISCU,PLOD1,DNAJC24 |
Interacting Protein
Fto has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Fto here. Most of them are supplied by our site. Hope this information will be useful for your research of Fto.
GABARAPL2;SLX4
Resources
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References
- Hwang, HJ; Kim, HS; et al. Ultra-High Speed Fabrication of TiO2 Photoanode by Flash Light for Dye-Sensitized Solar Cell. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15:5028-5034(2015).
- Song, YS; Kim, BY; et al. Effect of Al Doping on Optical Band Gap Energy of Al-TiO2 Thin Films. JOURNAL OF NANOSCIENCE AND NANOTECHNOLOGY 15:5228-5231(2015).
