FXR1
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Official Full Name
fragile X mental retardation, autosomal homolog 1 -
Overview
Fragile X mental retardation-related protein 1 (FXR1) and FXR2 are members of the FMR1 family sharing a very high degree of protein similarity among them. They interact with each other and also with FMR1, moving between the cytoplasm and the nucleus. FXR1 is an RNA binding protein and is expressed in the heart, kidney, brain, and testis. Mutations in FMR1 result in the most common form of mental retardation. -
Synonyms
FXR1;fragile X mental retardation, autosomal homolog 1;fragile X mental retardation syndrome-related protein 1;hFXR1p;FXR1P
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- In Vitro Cell Free System
- GST
- His
- Non
- His&GST
- His&Fc&Avi
Involved Pathway
FXR1 involved in several pathways and played different roles in them. We selected most pathways FXR1 participated on our site, such as RNA transport, which may be useful for your reference. Also, other proteins which involved in the same pathway with FXR1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RNA transport | NUP62,SUMO2,MAGOHB,ALYREF,EIF1AXB,FXR2,NUP153,EEF1A1A,RPP25L,XPO1 |
Protein Function
FXR1 has several biochemical functions, for example, G-quadruplex RNA binding,RNA binding,mRNA 3-UTR binding. Some of the functions are cooperated with other proteins, some of the functions could acted by FXR1 itself. We selected most functions FXR1 had, and list some proteins which have the same functions with FXR1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| mRNA binding | QKI,EIF4A1,G3BP1,CSTF2,RBM5,RPL13A,ZFP36L1,FXR2,EIF4ENIF1,LUC7L |
| poly(A) RNA binding | MRPL3,RPL5B,PARP1,CSTF3,EIF4G3,ANP32A,PDIA3,WDR43,GTF2F1,ZFP579 |
| RNA binding | MOV10B.1,TRIM71,KHDC1,RPS25,ZFP385C,FMR1,C14orf166,RBM39A,LIN28A,RAVER2 |
| G-quadruplex RNA binding | DHX36,Aff2,PATL2 |
| mRNA 3-UTR binding | ELAVL2,RNPS1,TUT1,PARN,RBM4,CRYZ,LARP1,CSDA,PUM2,ANGEL2 |
Interacting Protein
FXR1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FXR1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FXR1.
CSNK2A1;PRSS23;HSPB1;GBP2;CRMP1;HABP4;q5nig6_fratt;RIF1;CYFIP2;CEP126;C14orf1;LUC7L2;UBA6;Max;ssrna_ug
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References
- Say, E; Tay, HG; et al. A Functional Requirement for PAK1 Binding to the KH(2) Domain of the Fragile X Protein-Related FXR1. MOLECULAR CELL 38:236-249(2010).
- Hofmann, I; Casella, M; et al. Identification of the junctional plaque protein plakophilin 3 in cytoplasmic particles containing RNA-binding proteins and the recruitment of plakophilins 1 and 3 to stress granules. MOLECULAR BIOLOGY OF THE CELL 17:1388-1398(2006).
