FDFT1
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Official Full Name
farnesyl-diphosphate farnesyltransferase 1 -
Overview
This gene encodes a membrane-associated enzyme located at a branch point in the mevalonate pathway. The encoded protein is the first specific enzyme in cholesterol biosynthesis, catalyzing the dimerization of two molecules of farnesyl diphosphate in a two-step reaction to form squalene. -
Synonyms
FDFT1;farnesyl-diphosphate farnesyltransferase 1;squalene synthase;squalene synthetase;FPP:FPP farnesyltransferase;presqualene-di-diphosphate synthase;SS;SQS;DGPT;ERG9
Recombinant Proteins
- Rhesus macaque
- Human
- Mouse
- Rat
- Chicken
- Zebrafish
- Pongo Abelii
- Mus musculus
- Bovine
- Mammalian Cell
- E.coli
- Wheat Germ
- HEK293
- Mammalian cells
- In Vitro Cell Free System
- HEK293T
- E.coli expression system
- His
- Non
- Flag
- His&Fc&Avi
- Myc&DDK
- GST
Involved Pathway
FDFT1 involved in several pathways and played different roles in them. We selected most pathways FDFT1 participated on our site, such as Steroid biosynthesis,Metabolic pathways, which may be useful for your reference. Also, other proteins which involved in the same pathway with FDFT1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ANPEPB,GCSH,AMPD1,CDO1,PTGDSB,NDUFB1,NADKD1,IMPA1,ADA,ALOX5A |
| Steroid biosynthesis | HSD17B7,Cel,FAXDC2,CYP2R1,SQLE,CYP51,CPN1,EBP,NSDHL,DHCR24 |
Protein Function
FDFT1 has several biochemical functions, for example, farnesyl-diphosphate farnesyltransferase activity,oxidoreductase activity,squalene synthase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FDFT1 itself. We selected most functions FDFT1 had, and list some proteins which have the same functions with FDFT1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| oxidoreductase activity | P4HA1B,HSD17B12A,PRODH2,DHRS3B,VAT1L,GPX4A,RDH14A,CBR1L,SARDH,H2-KE6 |
Interacting Protein
FDFT1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FDFT1 here. Most of them are supplied by our site. Hope this information will be useful for your research of FDFT1.
PSTPIP1;SMNDC1;C1orf168;RUVBL1;ANXA5;ITGB5;SHPRH;ARL6IP1;TMEM43;RUVBL2;15-deoxy-delta(12,14;FN1;1C;HDAC10
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