FCGR1A
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Official Full Name
Fc fragment of IgG, high affinity Ia, receptor (CD64) -
Overview
CD64 is the high-affinity IgG Fc receptor belonging to the immunoglobulin supergene family (Guyre, 2002). CD64 is a 72 kDa glycoprotein which binds monomeric IgG (human IgG1>IgG3>>IgG4>>>IgG2 and mouse IgG3>IgG2a>>>IgG1, IgG2b). Three genes: FcgammaR1A, FcgammaR1B and FcgammaR1C, which have >98 percent identity at the nucleotide level, have been identified and mapped to chromosome 1, band q21.1 (Sun,1997)). The FcgammaR1A gene, which specified the high-affinity IgG receptor, encodes three C2-type Ig-like extracellular domains, a 21 amino acid transmembrane region, and a charge cytoplasmic tail of 61 amino acids (Sun, 1997)(van de Winkel,1993). -
Synonyms
FCGR1A;Fc fragment of IgG, high affinity Ia, receptor (CD64);high affinity immunoglobulin gamma Fc receptor I;Fc receptor, IgG, high affinity I;high affinity IgG Fc receptor, subunit beta;Fc fragment of IgG high affinity Ib receptor;high-affinity immunoglobulin gamma Fc receptor I;Fc fragment of IgG, high affinity Ib, receptor for (CD64);Fcgr1;Fcgr1b;FcgammaRI
Recombinant Proteins
- Human
- Rat
- Cynomolgus
- Rhesus macaque
- Rabbit
- HEK293
- E.coli
- Mouse myeloma cell line
- Wheat Germ
- Human
- Human Cell
- CHO
- Mouse
- In vitro E. coli expression system
- Human cells
- Mammalian cells
- In Vitro Cell Free System
- E.coli expression system
- His&Avi
- His
- Non
- mFc
- mIgG2a
- Fc
- GST
- Flag
Involved Pathway
FCGR1A involved in several pathways and played different roles in them. We selected most pathways FCGR1A participated on our site, such as Phagosome,Osteoclast differentiation,Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with FCGR1A were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Tuberculosis | IRAK2,MRC2,IL12A,MAPK13,IFNGR2,FCGR4,IFNG,H2-AA,HLA-DQA2,HLA-DPA1 |
| Phagosome | TUBA1A,HLA-DPB1,ATP6V1E1,THBS4A,ITGB1,ATP6V0E2,TUBB2B,Pla2r1,RAB5B,SEC22B |
| Hematopoietic cell lineage | FCGR1,GM-CSF,CD1E,Kitl,FLT3LG,CD3E,MME,CD8B1,GP1BB,CR1 |
| Leishmaniasis | IL12B,CR1,MAP3K7,HLA-DPB1,TLR2,ITGB2L,FCGR2C,MAPK11,MAPK13,FCGR1 |
| Transcriptional misregulation in cancer | HIST1H3A,FCGR1,IGFBP3,ATM,PML,MLF1,LDB1,TRP53,SIN3A,TLX3 |
| Osteoclast differentiation | NFATC2,TRAF6,IFNGR2,PIK3R3,FOS,FCGR3B,NFKB2,MAPK1,TGFB1,FCGR2C |
| Systemic lupus erythematosus | C7,HIST1H3D,FCGR4,H3F3A,HIST1H4J,H2AFZ,HLA-DRB1,C8G,TNF,C5 |
| Staphylococcus aureus infection | DSG1C,HLA-DPB1,HLA-DRB4,ITGAL,C3,FPR1,C1RA,Hc,HLA-DMB,HLA-DQA1 |
| Fc gamma R-mediated phagocytosis | SYK,PIK3CD,PRKCE,PLD2,FCGR2B,LYN,DOCK2,HCK,PPAP2C,MAPK1 |
Protein Function
FCGR1A has several biochemical functions, for example, IgG binding,protein binding,receptor signaling protein activity. Some of the functions are cooperated with other proteins, some of the functions could acted by FCGR1A itself. We selected most functions FCGR1A had, and list some proteins which have the same functions with FCGR1A. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | ACYP2,BMP4,PDE9A,FAM109B,EDC4,DNAJA2,SLC25A23,RND2,CARD8,PPP2R1B |
| IgG binding | FCGR3B,UMOD,PIP,FCGR3A,FCGR2B,cgr2b,FCGR2A,FCGR1B,FCER1G,FCGR1 |
| receptor signaling protein activity | PLCE1,TYROBP,FCAR,KLK1B3,cgr2b,DCLK1,RAF1B,TIAM2,NGF,TRAIP |
Interacting Protein
FCGR1A has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with FCGR1A here. Most of them are supplied by our site. Hope this information will be useful for your research of FCGR1A.
FCGR3A;SYK;hldE;CBL;SHC1;LCP2
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