EPHB2
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Official Full Name
EPH receptor B2 -
Overview
Ephrin receptors and their ligands, the ephrins, mediate numerous developmental processes, particularly in the nervous system. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. Ephrin receptors make up the largest subgroup of the receptor tyrosine kinase (RTK) family. The protein encoded by this gene is a receptor for ephrin-B family members. -
Synonyms
EPHB2;EPH receptor B2;DRT, EphB2 , EPHT3, ERK;ephrin type-B receptor 2;Hek5;Tyro5;EPH-like kinase 5;eph tyrosine kinase 3;elk-related tyrosine kinase;protein-tyrosine kinase HEK5;tyrosine-protein kinase TYRO5;renal carcinoma antigen NY-REN-47
Recombinant Proteins
- Human
- Cynomolgus
- Mouse
- Chicken
- E.coli
- HEK293
- C-His
- Baculovirus
- Mammalian cells
- Sf9 Insect Cell
- Wheat Germ
- Human Cell
- Mammalian Cell
- Insect Cells
- Insect Cell
- GST
- His&Fc
- His
- Non
- His&Flag
- Fc
- His&GST
- His&Fc&Avi
Involved Pathway
EPHB2 involved in several pathways and played different roles in them. We selected most pathways EPHB2 participated on our site, such as Axon guidance, which may be useful for your reference. Also, other proteins which involved in the same pathway with EPHB2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Axon guidance | SEMA4D,ARPC4,SPNA1,DCC,ARPC2,JAK1,EPHA5,NRG4,DNM1,DPYSL2B |
Protein Function
EPHB2 has several biochemical functions, for example, ATP binding,protein binding,protein tyrosine kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EPHB2 itself. We selected most functions EPHB2 had, and list some proteins which have the same functions with EPHB2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ATP binding | ATP13A1,GARS,PL10,CMPK1,MAP4K2,HK3,ABCD4,ABCD3B,SLC14A2,ACSS2 |
| transmembrane-ephrin receptor activity | EFNA3,EPHA1,EPHA5,EFNB3,EFNA4,EPHB1,EPHA10,EPHA4 |
| protein binding | KCNMA1,PIH1D1,KCNJ15,SIX5,DNAI1,MYLIP,SEC63,ARL4C,DNAJA3,CDK18 |
| protein tyrosine kinase activity | MET,EGFR,MAP3K9,FGFR1A,DYRK4,BCR,TNK2B,MAP2K2,FGFR1,FYNB |
Interacting Protein
EPHB2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EPHB2 here. Most of them are supplied by our site. Hope this information will be useful for your research of EPHB2.
NUP153;ephopt;24308301;RBL1;PTP4A2;MLLT4;pi3p;linkable pd173955 analogue;bosutinib;imatinib;purvalanol b;MAPK14
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References
- Zhu, LF; Dissanayaka, WL; et al. Stimulation of EphB2/ephrin-B1 signalling by tumour necrosis factor alpha in human dental pulp stem cells. CELL PROLIFERATION 48:231-238(2015).
- Eriksson, O; Ramstrom, M; et al. The Eph Tyrosine Kinase Receptors EphB2 and EphA2 Are Novel Proteolytic Substrates of Tissue Factor/Coagulation Factor VIIa. JOURNAL OF BIOLOGICAL CHEMISTRY 289:-(2014).
