EOMES
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Official Full Name
eomesodermin -
Overview
This gene belongs to the TBR1 (T-box brain protein 1) sub-family of T-box genes that share the common DNA-binding T-box domain. The encoded protein is a transcription factor which is crucial for embryonic development of mesoderm and the central nervous system in vertebrates. The protein may also be necessary for the differentiation of effector CD8+ T cells which are involved in defense against viral infections. A similar gene disrupted in mice is shown to be essential during trophoblast development and gastrulation. Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2013] -
Synonyms
EOMES;eomesodermin;TBR2;eomesodermin homolog;T-box brain protein 2
Recombinant Proteins
- Mouse
- Human
- Mammalian Cell
- Wheat Germ
- E.coli
- HEK293
- HEK293T
- His
- GST
- Non
- His&GST
- His&Fc&Avi
- Myc&DDK
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| EOMES-5228M | Recombinant Mouse EOMES Protein | Mammalian Cell | Mouse | His | ||
| EOMES-3344H | Recombinant Human EOMES Protein, GST-tagged | Wheat Germ | Human | GST |
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| EOMES-389H | Recombinant Human EOMES Protein, His-tagged | E.coli | Human | His |
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| EOMES-6589HCL | Recombinant Human EOMES 293 Cell Lysate | HEK293 | Human | Non |
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| EOMES-1649H | Recombinant Human EOMES protein, His & GST-tagged | E.coli | Human | His&GST | Leu400~Ser669 |
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| EOMES-2807M | Recombinant Mouse EOMES Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| EOMES-2807M-B | Recombinant Mouse EOMES Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| EOMES-301271H | Recombinant Human EOMES protein, GST-tagged | E.coli | Human | GST | Met575-Met676 |
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| EOMES-3345H | Recombinant Human EOMES Protein, Myc/DDK-tagged | HEK293T | Human | Myc&DDK | Full L. |
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Involved Pathway
EOMES involved in several pathways and played different roles in them. We selected most pathways EOMES participated on our site, such as Downstream signaling in naive CD8+ T cells,IL12-mediated signaling events, which may be useful for your reference. Also, other proteins which involved in the same pathway with EOMES were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| IL12-mediated signaling events | HLX,GADD45G |
| Downstream signaling in naive CD8+ T cells | JUNB,EGR1,EGR4 |
Protein Function
EOMES has several biochemical functions, for example, DNA binding,RNA polymerase II activating transcription factor binding,RNA polymerase II regulatory region sequence-specific DNA binding. Some of the functions are cooperated with other proteins, some of the functions could acted by EOMES itself. We selected most functions EOMES had, and list some proteins which have the same functions with EOMES. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA binding | HMGB1B,PHOX2BB,HOXB6B,PRRX1A,ATF4B1,MKXA,MSXA,NR5A1,GTF2IRD2,ADAR |
| transcriptional repressor activity, RNA polymerase II transcription factor binding | TBX6,AHRR,AHRRA,T,AHRRB,MINA,RIMKLB,CREBBP,PITX2,BHLHE40 |
| sequence-specific DNA binding | GSX1,GATA4,SALL2,NCOR1,HOXC8,HOXB6,RAX2,MAF,TFAP4,PPARDB |
| chromatin binding | CEBPB,CHAF1A,SMC1AL,APTX,UXT,TLE1,CBFA2T3,TRPS1,ZGLP1,PRKCBB |
| RNA polymerase II regulatory region sequence-specific DNA binding | FERD3L,STOX1,GATA1,ATF5A,RXRA,XBP1,TAL1,ZNF79,GATA5,GATA2 |
| RNA polymerase II activating transcription factor binding | ATF2,LDB1,TP53BP1,MAD2L2,DUSP26,IFI27,T,NEUROD1,POU1F1,NHLH2 |
| transcription factor activity, sequence-specific DNA binding | EGR3,ZNF26,RB1,RUNX2,SMAD6,E2F4,HIF1AL,ZSCAN4D,MEOX1,RFXANK |
Interacting Protein
EOMES has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EOMES here. Most of them are supplied by our site. Hope this information will be useful for your research of EOMES.
PFDN1;sgrR;purR2
Resources
Research Area
Early Endodermal Lineage MarkersEarly Mesodermal Lineage Markers
Trophoblast Stem Cell Markers
Pluripotent Stem Cell Transcription Factors
gamma delta T Cells
T Cell Cytokine Signaling
Ectodermal Lineage Markers
Endodermal Lineage Markers
Mesodermal Lineage Markers
Neural Progenitor Cell Markers
Related Services
Related Products
References
- Kim, K; Bang, SY; et al. High-density genotyping of immune loci in Koreans and Europeans identifies eight new rheumatoid arthritis risk loci. ANNALS OF THE RHEUMATIC DISEASES 74:-(2015).
- Chen, SH; Lee, LF; et al. Combination of 4-1BB Agonist and PD-1 Antagonist Promotes Antitumor Effector/Memory CD8 T Cells in a Poorly Immunogenic Tumor Model. CANCER IMMUNOLOGY RESEARCH 3:149-160(2015).
