EFNB3
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Official Full Name
ephrin-B3 -
Overview
EFNB3, a member of the ephrin gene family, is important in brain development as well as in its maintenance. Moreover, since levels of EFNB3 expression were particularly high in several forebrain subregions compared to other brain subregions, it may play a pivotal role in forebrain function.The EPH and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, particularly in the nervous system. EPH Receptors typically have a single kinase domain and an extracellular region containing a Cys-rich domain and 2 fibronectin type III repeats. The ephrin ligands and receptors have been named by the Eph Nomenclature Committee (1997). Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. The Eph family of receptors are similarly divided into 2 groups based on the similarity of their extracellular domain sequences and their affinities for binding ephrin-A and ephrin-B ligands. -
Synonyms
EFNB3;ephrin-B3;EPLG8;LERK 8;Ephrin B3;eph-related receptor tyrosine kinase ligand 8;EPH-related receptor transmembrane ligand ELK-L3;EFL6;LERK8
Recombinant Proteins
- Human
- Mouse
- Rat
- Insect Cells
- Mammalian cells
- E.coli
- Mammalian Cell
- HEK293
- Human Cell
- Yeast
- His&Fc
- Fc
- Non
- His
- His&Fc&Avi
Involved Pathway
EFNB3 involved in several pathways and played different roles in them. We selected most pathways EFNB3 participated on our site, such as Axon guidance,Developmental Biology,EPH-Ephrin signaling, which may be useful for your reference. Also, other proteins which involved in the same pathway with EFNB3 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| EPH-ephrin mediated repulsion of cells | EFNB1,EPHA10,AP2A2,EFNA1B,EFNA2,EFNA1,EFNA3B,EFNB2,EFNA1A,EFNB3B |
| EPHB forward signaling | ITSN1,GRB7,EFNA5,EFNB1,EFNB2 |
| Ephrin signaling | MYL12A,EFNB2,EPHB3A,EFNB2A,EPHB4A,EFNB3B,EFNB1,EPHB4B,SDCBP |
| Axon guidance | FES,NCAN,CSF2,MAPK3,SHB,FRS2B,PPP3R2,PAK2,EPHA1,DPYSL2B |
| EPH-Ephrin signaling | AP2M1,ACTR2B,ARPC5,EFNA3,ARPC3,EPHA2,EFNA2A,EFNB1,CLTB,MYL12B |
| EPHB-mediated forward signaling | ARPC4,EFNB2A,EFNB1,ITSN1,EFNB3B,EPHB4B,ACTR2,ACTR2B,ARPC1A,EPHB4A |
| Developmental Biology | CDH4,GDF1,ARPC2,SPRED3,EFNA1A,TCF12,SPTBN2,GPC1A,COL9A1,PAK4 |
Protein Function
EFNB3 has several biochemical functions, for example, ephrin receptor binding,transmembrane-ephrin receptor activity,virus receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EFNB3 itself. We selected most functions EFNB3 had, and list some proteins which have the same functions with EFNB3. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| ephrin receptor binding | EFNA3,SRC,CRK,EPHA7,SDCBP,Anks1,GRB2,EPHA4,EFNB3B,CHN1 |
| virus receptor activity | CLEC5A,ICAM1,SERPINB4,CXADR,IDE,ITGA2,XPR1,F11R,PVRL4,ITGB1 |
| transmembrane-ephrin receptor activity | EPHA5,EPHA10,EFNA3,EPHA4,EFNA4,EPHB2,EPHA1,EPHB1 |
Interacting Protein
EFNB3 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EFNB3 here. Most of them are supplied by our site. Hope this information will be useful for your research of EFNB3.
YWHAZ;TCEB1;P2RX7;AATF
Resources
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References
- Steffen, DL; Xu, K; et al. Henipavirus Mediated Membrane Fusion, Virus Entry and Targeted Therapeutics. VIRUSES-BASEL 4:280-308(2012).
- Baniwal, SK; Chimge, NO; et al. Prolactin-Induced Protein (PIP) Regulates Proliferation of Luminal A Type Breast Cancer Cells in an Estrogen-Independent Manner. PLOS ONE 8:-(2013).
