EDF1
-
Official Full Name
endothelial differentiation-related factor 1 -
Overview
This gene encodes a protein that may regulate endothelial cell differentiation. It has been postulated that the protein functions as a bridging molecule that interconnects regulatory proteins and the basal transcriptional machinery, thereby modulating the transcription of genes involved in endothelial differentiation. This protein has also been found to act as a transcriptional coactivator by interconnecting the general transcription factor TATA element-binding protein (TBP) and gene-specific activators. Two alternatively spliced transcripts which encode distinct proteins have been found for this gene. -
Synonyms
EDF1;endothelial differentiation-related factor 1;EDF 1;multiprotein bridging factor 1;MBF1;EDF-1;MGC9058
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Rhesus macaque
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- HEK293
- Mammalian cells
- HEK293T
- In Vitro Cell Free System
- E. coli
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
Involved Pathway
EDF1 involved in several pathways and played different roles in them. We selected most pathways EDF1 participated on our site, such as , which may be useful for your reference. Also, other proteins which involved in the same pathway with EDF1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|
Protein Function
EDF1 has several biochemical functions, for example, calmodulin binding,NOT histone acetyltransferase activity,NOT methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by EDF1 itself. We selected most functions EDF1 had, and list some proteins which have the same functions with EDF1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription coactivator activity | GABPA,NCOA1,TCERG1,MED23,BRDT,MYOD1,ASXL1,GATA3,JUNB,SERTAD2 |
| calmodulin binding | CNN3B,PLCB1,SPATA17,KCNH1,SPTAN1,SPHK1,CNN1,RIT1,MARCKSA,MYH3 |
| NOT histone acetyltransferase activity | BRCA2,ARRB1,BAZ1A |
| protein binding | PTPRS,NR2C2AP,TEX14,NMU,ZBED3,LHX9,ZNF34,CRLF1,CSNK2A2,BICC1 |
| sequence-specific DNA binding | HOXA7,HOXA13,NFE2,ELK4,NR2F6B,ETS1,ZFP536,FOXO1,GLI2A,VSX1 |
| NOT transcription factor activity, sequence-specific DNA binding | RBCK1,DMRTB1 |
| poly(A) RNA binding | CDKN2A,G3BP1,RPS11,CCDC9,COA6,ANP32A,DHX8,RPS24,HDGF,GNL3L |
Interacting Protein
EDF1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with EDF1 here. Most of them are supplied by our site. Hope this information will be useful for your research of EDF1.
PPARG;NR1H3;MEOX2;NS;ESR1;NR5A2;RXRA;TBP;MAPK6;recR
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