E2F2
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Official Full Name
E2F transcription factor 2 -
Overview
E2F transcription factors are functionally regulated by binding to Rb p110, p107, and p130. E2F-2 is regulated by complex formation with Rb p110. E2F family members bind DNA as heterodimers with members of the DP family of polypeptides. -
Synonyms
E2F2;E2F transcription factor 2;transcription factor E2F2;E2F 2;E2F-2
Recombinant Proteins
- Human
- Mouse
- Wheat Germ
- Mammalian Cell
- In Vitro Cell Free System
- E.coli
- HEK293
- Non
- GST
- His
- His&GST
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| E2F2-27376TH | Recombinant Human E2F2 | Wheat Germ | Human | Non | 83 amino acids |
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| E2F2-3004H | Recombinant Human E2F2 Protein, GST-tagged | Wheat Germ | Human | GST |
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| E2F2-4931M | Recombinant Mouse E2F2 Protein | Mammalian Cell | Mouse | His |
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| E2F2-520HCL | Recombinant Human E2F2 cell lysate | Human | Non |
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| E2F2-133HF | Recombinant Full Length Human E2F2 Protein | In Vitro Cell Free System | Human | Full L. 83 amino acids |
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| E2F2-1635H | Recombinant Human E2F2 protein, His & GST-tagged | E.coli | Human | His&GST | Arg129~Tyr429 |
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| E2F2-2017H | Recombinant Human E2F2 Protein (Arg129-Tyr429), N-His tagged | E.coli | Human | His | Arg129-Tyr429 |
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| E2F2-2595M | Recombinant Mouse E2F2 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| E2F2-2595M-B | Recombinant Mouse E2F2 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| E2F2-4111HF | Recombinant Full Length Human E2F2 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 83 amino acids |
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Involved Pathway
E2F2 involved in several pathways and played different roles in them. We selected most pathways E2F2 participated on our site, such as Assembly of the pre-replicative complex,Association of licensing factors with the pre-replicative complex,Bladder cancer, which may be useful for your reference. Also, other proteins which involved in the same pathway with E2F2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Association of licensing factors with the pre-replicative complex | E2F3,GMNN,E2F1,CDT1 |
| Cellular Senescence | HIST1H1D,EHMT2,CBX6A,SUZ12A,H3F3D,HMGA1B,BMI1A,AGO3,RNF2,H1F0 |
| Cell Cycle, Mitotic | MCM10,HIST3H2BB,PLK4,CNEP1R1,TUBGCP2,TSGA14,STAG1,STIL,AURKB,CTDNEP1 |
| Assembly of the pre-replicative complex | GMNN,CDT1,MCM8,E2F3,E2F1 |
| Bladder cancer | MMP9,BRAF,MAPK3,SRC,MAP2K1,EGF,TYMP,TP53,ERBB2,E2F1 |
| CDC6 association with the ORC:origin complex | MCM8,E2F3 |
| Cell cycle | LIN54,CDC14AB,ANAPC4,WEE1,NEK6,LEMD3,MYBL2,MCM3,APITD1,NUDC |
Protein Function
E2F2 has several biochemical functions, for example, DNA binding,core promoter binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by E2F2 itself. We selected most functions E2F2 had, and list some proteins which have the same functions with E2F2. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| transcription factor activity, sequence-specific DNA binding | ZFP879,FOXG1,POU2F2,CDX2,TP63,TEAD1A,GATAD2A,VED,CREBZF,GTF2IRD1 |
| protein binding | GPSM3,ZFP36,BTC,NIF3L1,FBXW2,PCBP2,TRMT2B,FBLN1,DYNC2LI1,SCRN1 |
| core promoter binding | KLF4,EZH2,MTA1,GTF2B,E2F7,MTF1,HDAC6,NOTCH1,HMGA2,IFI203 |
| transcription factor binding | JUN,NKX2-5,DR1,GTF2A2,GATA4,HES7,TBP,HDAC8,ESRRB,TFDP2 |
| DNA binding | CROP,PLSCR1,ZFP64,NR5A5,HOXA1A,ZNF581,HLTF,MB21D2,GTF2IRD1,ZSCAN10 |
Interacting Protein
E2F2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with E2F2 here. Most of them are supplied by our site. Hope this information will be useful for your research of E2F2.
RB1;Sp1;E7;E2F1;MCPH1;GNB5;BCAR1;GIT2;q81sn0_bacan;Cep152
Resources
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References
- Bucasas, KL; Franco, LM; et al. Early Patterns of Gene Expression Correlate With the Humoral Immune Response to Influenza Vaccination in Humans. JOURNAL OF INFECTIOUS DISEASES 203:921-929(2011).
- Chafin, CB; Regna, NL; et al. MicroRNA-let-7a promotes E2F-mediated cell proliferation and NF kappa B activation in vitro. CELLULAR & MOLECULAR IMMUNOLOGY 11:79-93(2014).
