Dock8

  • Official Full Name

    dedicator of cytokinesis 8

Recombinant Proteins

  • Human
  • Mouse
  • HEK293
  • Mammalian Cell
  • Yeast
  • E.coli
  • HEK293T
  • Myc&DDK
  • His
  • His&Fc&Avi

    Involved Pathway

    Dock8 involved in several pathways and played different roles in them. We selected most pathways Dock8 participated on our site, such as Factors involved in megakaryocyte development and platelet production,Hemostasis,cyclic AMP biosynthesis, which may be useful for your reference. Also, other proteins which involved in the same pathway with Dock8 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Factors involved in megakaryocyte development and platelet production KIF2A,HBE1,MFN2,DOCK10,GATA1,ZFPM2A,MAFG,HBG2,MAFF,NFE2
    cyclic AMP biosynthesis RIC8,GARNL3,RAP1GAP2,PDC,RALGAPA1,ARHGAP33
    Hemostasis DOCK11,CFHL2,KLC3,GRB7,HBBE2,BSG,KIF4,SERPINA1L,SIRPA,CLU

    Protein Function

    Dock8 has several biochemical functions, for example, guanyl-nucleotide exchange factor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by Dock8 itself. We selected most functions Dock8 had, and list some proteins which have the same functions with Dock8. You can find most of the proteins on our site.

    Function Related Protein
    guanyl-nucleotide exchange factor activity DOCK11,PLCE1,RASGRP1,ARFGEF1,FGD1,ARHGEF19,FGD5,KALRN,RALGDS,GAPVD1

    Interacting Protein

    Dock8 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with Dock8 here. Most of them are supplied by our site. Hope this information will be useful for your research of Dock8.

    Resources

    References

    • Burbage, M; Keppler, SJ; et al. Cdc42 is a key regulator of B cell differentiation and is required for antiviral humoral immunity. JOURNAL OF EXPERIMENTAL MEDICINE 212:53-72(2015).
    • Janssen, E; Morbach, H; et al. Dedicator of cytokinesis 8-deficient patients have a breakdown in peripheral B-cell tolerance and defective regulatory T cells. JOURNAL OF ALLERGY AND CLINICAL IMMUNOLOGY 134:1365-1374(2014).

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