DNMT3B
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Official Full Name
Dnmt3b DNA methyltransferase 3B -
Overview
Dnmt3b (DNA (cytosine-5-)-methyltransferase 3b) has a role in the establishment and regulation of tissue-specific patterns of methylated cytosine residues (epigenetics). Dnmt3b is thought to function in de novo methylation rather than maintenance methylation. The protein localizes primarily to the nucleus and its expression is developmentally regulated. Mutations in this gene cause the immunodeficiency-centromeric instability-facial anomalies (ICF) syndrome. -
Synonyms
DNMT3B;DNA methyltransferase 3B;DNA (cytosine-5)-methyltransferase 3B;m.MmuIIIB;DNA MTase MmuIIIB;DNA methyltransferase MmuIIIB;MGC124407
Recombinant Proteins
- Human
- Chicken
- Zebrafish
- Mouse
- E.coli
- Sf9 Insect Cell
- Mammalian Cell
- Wheat Germ
- Insect Cell
- HEK293
- Insect Cells
- HEK293T
- Mammalian cells
- In Vitro Cell Free System
- HEK293F
- GST
- His
- Non
- His&GST
- His&T7
- N-6xHis
- Myc&DDK
- Flag
- His&Fc&Avi
Involved Pathway
DNMT3B involved in several pathways and played different roles in them. We selected most pathways DNMT3B participated on our site, such as Cysteine and methionine metabolism,DNA methylation,Epigenetic regulation of gene expression, which may be useful for your reference. Also, other proteins which involved in the same pathway with DNMT3B were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Metabolic pathways | ADO,NDUFB2,ENPP3,CYP19A1,AGXTB,INPP4AB,GALNS,UGT2B7,DPYS,CYP26C1 |
| Epigenetic regulation of gene expression | H3F3D,MTF2,TET2,JARID2,JARID2B,TAF1D,TAF1C,DNMT3L,SMARCA5,EED |
| Cysteine and methionine metabolism | ENOPH1,MRI1,GCLM,MPST,BCAT2,DNMT1,DNMT3A,CTH,AGXT2,MAT2AA |
| Negative epigenetic regulation of rRNA expression | SUDS3,SAP130,SAP30BP,TAF1C,EFCAB11,DNMT1,TAF1D,SAP30L,SAP30,CD3EAP |
| Gene Expression | ZNF12,MTA2,ZFP473,ZNF649,ZNF398,MED13A,FAUB,ZNF473,ADARB1,MED16 |
| NoRC negatively regulates rRNA expression | EFCAB11,SAP130,BAZ2A,DNMT1,TAF1B,CD3EAP,TAF1A,TAF1C,TAF1D,SAP30L |
| MicroRNAs in cancer | PIM1,TRIM71,PRKCA,ZFPM2,PDGFB,IKBKB,HDAC1,TNXB,BCL2,CCND2 |
| DNA methylation | DNMT3A,DNMT1,DNMT3L,UHRF1 |
Protein Function
DNMT3B has several biochemical functions, for example, DNA (cytosine-5-)-methyltransferase activity,DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates,DNA-methyltransferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DNMT3B itself. We selected most functions DNMT3B had, and list some proteins which have the same functions with DNMT3B. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| DNA-methyltransferase activity | TRMT10C,RNMTL1A,PRDM12,MGMT,RNMTL1B,PRDM11,NDUFAF5,METTL8,DNMT3AA,METTL23 |
| DNA (cytosine-5-)-methyltransferase activity, acting on CpG substrates | DNMT3A |
| unmethylated CpG binding | MLL1,KDM2A,DNMT3A,CXXC1 |
| histone deacetylase binding | NRIP1,MAPK8,SRF,KLF4,NACC2,RAD9,TRAF6,SFPQ,SIRT2,NCOR1 |
| protein binding | OSTB,LAX1,PSMB1,PLK1,TXK,ZNF559-ZNF177,SP1,LDHB,DDX3X,ANKMY2 |
| DNA (cytosine-5-)-methyltransferase activity | DNMT3A,TRDMT1,DNMT1 |
| transcription corepressor activity | PIAS1,LHX1A,CBFA2T3,SKOR1A,HIF3A,SKI,WTIP,ZHX3,SIAH2,ZHX2 |
| chromatin binding | HMGA1,ZKSCAN3,HMGXB4,CDCA5,HMG20B,HDGFRP2,HDAC7,PCNA,UBTF,MSL1 |
| metal ion binding | HPDB,BCL11AB,HPD,DDX11,REV1,MARCH5L,ZFP511,ACAN,TKTL1,ZFP580 |
Interacting Protein
DNMT3B has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DNMT3B here. Most of them are supplied by our site. Hope this information will be useful for your research of DNMT3B.
EZH2;EED;SUMO1;UHRF1
Resources
Research Area
Hematopoietic Stem Cell Transcription Factors and RegulatorsEmbryonic and Induced Pluripotent Stem Cell Markers
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References
- Gonzalez-Bosquet, J; Chu, YL; et al. Development of an Intracellular, DNA Methyltransferase-Specific, and Gene-Specific Assay for Studying Dynamic DNA Methylation. CURRENT PHARMACEUTICAL DESIGN 20:1664-1673(2014).
- Zhou, HY; Li, JP; et al. Hypomethylation and Activation of Syncytin-1 Gene in Endometriotic Tissue. CURRENT PHARMACEUTICAL DESIGN 20:1786-1795(2014).
