DLL4
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Official Full Name
delta-like 4 (Drosophila) -
Overview
This gene is a homolog of the Drosophila delta gene. The delta gene family encodes Notch ligands that are characterized by a DSL domain, EGF repeats, and a transmembrane domain. [provided by RefSeq, Jul 2008] -
Synonyms
DLL4;delta-like 4 (Drosophila);hdelta2;delta-like protein 4;delta4;delta 4;delta ligand 4;notch ligand DLL4;delta-like 4 homolog;delta-like 4 protein;notch ligand delta-2;drosophila Delta homolog 4
Recombinant Proteins
- Human
- Mouse
- Zebrafish
- Rhesus macaque
- Rat
- HEK293
- Mammalian cells
- CHO cells
- Wheat Germ
- Mammalian Cell
- Insect Cell
- Human Cell
- Rabbit
- E.coli
- His
- Fc
- Fc&Avi
- His&Avi
- Non
- GST
- His&GST
- His&Fc&Avi
Involved Pathway
DLL4 involved in several pathways and played different roles in them. We selected most pathways DLL4 participated on our site, such as Notch signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with DLL4 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Notch signaling pathway | MAML1,CNTN6,HER15.1,ADAM17A,JAG2B,DTX3,DLL1,NOTCH1A,DVL3A,DNER |
Protein Function
DLL4 has several biochemical functions, for example, Notch binding,calcium ion binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DLL4 itself. We selected most functions DLL4 had, and list some proteins which have the same functions with DLL4. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | CCDC102A,SYT3,LPCAT1,PCDH10A,PCDHA2,EGFL7,ANXA2A,PLSCR1,S100A9,PCDH1G26 |
| protein binding | CCL20,ASAP2,GPS2,CLIC1,RAP2B,L3MBTL1,SLC14A2,PELI3,KRTAP9-4,TBP |
| Notch binding | EGFL7,JAG2,JAG1B,AAK1,NCOR2,DTX1,JAG1A,JAG1,NOTCH1,C8orf4 |
Interacting Protein
DLL4 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DLL4 here. Most of them are supplied by our site. Hope this information will be useful for your research of DLL4.
Resources
Research Area
Cancer Drug TargetsNotch Pathway
Notch Family
Gastric Cancer Stem Cell Markers
Breast Cancer Stem Cell Markers
Related Services
Related Products
References
- Accialini, P; Hernandez, SF; et al. A link between Notch and progesterone maintains the functionality of the rat corpus luteum. REPRODUCTION 149:1-10(2015).
- Minuzzo, S; Agnusdei, V; et al. DLL4 regulates NOTCH signaling and growth of T acute lymphoblastic leukemia cells in NOD/SCID mice. CARCINOGENESIS 36:115-121(2015).
