DGKA
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Official Full Name
diacylglycerol kinase, alpha 80kDa -
Overview
The protein encoded by this gene belongs to the eukaryotic diacylglycerol kinase family. It acts as a modulator that competes with protein kinase C for the second messenger diacylglycerol in intracellular signaling pathways. It also plays an important role in the resynthesis of phosphatidylinositols and phosphorylating diacylglycerol to phosphatidic acid. Alternative splicing occurs at this locus and four transcript variants encoding the same protein have been identified. -
Synonyms
DGKA;diacylglycerol kinase, alpha 80kDa;DAGK, DAGK1, diacylglycerol kinase, alpha (80kD);diacylglycerol kinase alpha;DGK alpha;DAG kinase alpha;diglyceride kinase alpha;80 kDa diacylglycerol kinase;DAGK;DAGK1;DGK-alpha;MGC12821;MGC42356
Recombinant Proteins
- Human
- Bacillus subtilis
- Rat
- Mouse
- Synechococcus sp.
- Pseudomonas aeruginosa
- Insect Cell
- E. coli or Yeast
- Mammalian Cell
- Wheat Germ
- HEK293
- HEK293T
- In Vitro Cell Free System
- E.coli
- Mammalian cells
- E.coli expression system
- GST
- His
- Non
- Myc&DDK
- His&Fc&Avi
- Flag
Involved Pathway
DGKA involved in several pathways and played different roles in them. We selected most pathways DGKA participated on our site, such as Calcineurin-regulated NFAT-dependent transcription in lymphocytes,Choline metabolism in cancer,Effects of PIP2 hydrolysis, which may be useful for your reference. Also, other proteins which involved in the same pathway with DGKA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| GPCR downstream signaling | DRD2,GPR55,ADRA2B,PPY,MLN,HEBP1,GPR132,PTGDR2,GNA13B,SSTR2 |
| Choline metabolism in cancer | PIK3CB,SLC44A1,PRKCG,RPS6KB1,RAC3,MAP2K2,MAP2K1,PIK3CD,DGKZ,SLC22A2 |
| G alpha (q) signalling events | RGS18,NMBB,EDNRAB,AGT,NPS,DGKB,ADRA1D,EDNRA,CASR,GCGB |
| Calcineurin-regulated NFAT-dependent transcription in lymphocytes | EGR4,CSF2,BATF3,CDK4,CTLA4,POU2F1,JUNB,EGR2,EGR3,IKZF1 |
| Glycerolipid metabolism | AGPAT9,PPAP2A,MBOAT2B,ALDH9A1B,glpK,DGAT1,AGPAT4,ALDH9A1A.1,DAK,TAE1 |
| Gastrin-CREB signalling pathway via PKC and MAPK | TRPC7,GPR65,TRPC6A,EDN2,OPN4.1,NPFF,GCGA,MGLL,HCRT,OPN4 |
| Glycerophospholipid metabolism | PLA2G4A,STIL,PCYT1BA,GPCPD1,PCYT1AB,ETNK2,CDS2,PCYT1AA,DGKD,PHYKPL |
| Effects of PIP2 hydrolysis | ABHD12,PRKCHB,DGKQ,ABHD6B,TRPC7,TRPC3,TRPC6A,RASGRP2,MGLL,TAE1 |
Protein Function
DGKA has several biochemical functions, for example, ATP binding,calcium ion binding,diacylglycerol kinase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DGKA itself. We selected most functions DGKA had, and list some proteins which have the same functions with DGKA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| calcium ion binding | OC90,S100P,JAG2,KIAA0494,PCDHGA4,ITSN2A,ATP2A2,BGLAP-RS1,SYT4,RASGRP2 |
| phospholipid binding | ANXA9,MYOF,SEC14L2,NSMAF,PSD4,PLEKHA3,PAFAH2,ABCG1,NBEAA,PLA2G7 |
| ATP binding | MAP2K4B,UBA2,CSNK1G2,AKT3,PRKCDA,ATRX,BMPR1BA,MCCC2,DDX18,STK11 |
| diacylglycerol kinase activity | DGKQ,DGKAA,DGKE,AGK,TAE1,DGKB,DGKD,DGKZ,DGKG |
Interacting Protein
DGKA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DGKA here. Most of them are supplied by our site. Hope this information will be useful for your research of DGKA.
SRC;IL21;adhB
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References
- Li, DF; Pye, VE; et al. Experimental phasing for structure determination using membrane-protein crystals grown by the lipid cubic phase method. ACTA CRYSTALLOGRAPHICA SECTION D-BIOLOGICAL CRYSTALLOGRAPHY 70:104-122(2015).
- Comba, S; Sabatini, M; et al. Engineering a Streptomyces coelicolor biosynthesis pathway into Escherichia coli for high yield triglyceride production. BIOTECHNOLOGY FOR BIOFUELS 7:-(2014).
