DCK
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Official Full Name
deoxycytidine kinase -
Overview
Deoxycytidine kinase (DCK) is required for the phosphorylation of several deoxyribonucleosides and their nucleoside analogs.Deficiency of DCK is associated with resistance to antiviral and anticancer chemotherapeutic agents.Conversely, increased deoxycytidine kinase activity is associated with increased activation of these compounds to cytotoxic nucleoside triphosphate derivatives.DCK is clinically important because of its relationship to drug resistance and sensitivity. -
Synonyms
DCK;deoxycytidine kinase;DCK protein;DCK_HUMAN;OTTHUMP00000160356;OTTHUMP00000219118;OTTHUMP00000219119;deoxynucleoside kinase
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Zebrafish
- Rat
- Mouse
- Bacillus subtilis
- E.coli
- Mammalian Cell
- Wheat Germ
- Sf9 Insect Cell
- HEK293
- E. coli
- E. coli or Yeast
- HEK293T
- In Vitro Cell Free System
- Yeast
- GST
- Non
- His
- Flag
- His&Strep
- His&Fc&Avi
- N-His&C-Myc
- His&T7
- Myc&DDK
Involved Pathway
DCK involved in several pathways and played different roles in them. We selected most pathways DCK participated on our site, such as Metabolic pathways,Metabolism,Metabolism of nucleotides, which may be useful for your reference. Also, other proteins which involved in the same pathway with DCK were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| RB in Cancer | TOP2A,ANLN,PRMT2,SMARCA2,RABIF,RBP1,HLTF,HMGB2,FAF1 |
| Purine salvage | ADAL,DGUOK,PNP5B,ADK,TM9SF1,ADA |
| Pyrimidine salvage reactions | UPP2 |
| Metabolism | CPOX,GLYAT,SLC35B2,OAZ1,APOC2,CYP2K6,CYP19A1,TPMT.2,COX4I1,ST3GAL3A |
| Purine metabolism | POLR2G,PKMB,GUK1A,NUDT5,ENTPD2,ENTPD6,PDE3A,POLR1C,GMPS,NT5C2 |
| Metabolism of nucleotides | DTYMK,ADK,ITPA,ADSS,NUDT15,ADA,DPYD,AK8,UPP2,DPYDA.1 |
| Metabolic pathways | B4GALT2,GCNT4,MGAT2,NDUFA10,PTGS2,B3GALT6,AMY2A2,GALNT9,PTS,HDC |
| Pyrimidine metabolism | POLR2F,ENTPD3,POLR2H,NME2,POLD4,UCKL1,ENTPD1,PROZA,UPRT,NME2B.2 |
Protein Function
DCK has several biochemical functions, for example, ATP binding,deoxycytidine kinase activity,drug binding. Some of the functions are cooperated with other proteins, some of the functions could acted by DCK itself. We selected most functions DCK had, and list some proteins which have the same functions with DCK. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein homodimerization activity | MAOB,ABCD1,CAMK2D,PPP2R4,CD247,KIAA1804,TGFB2,NR6A1A,FLRT3,PVRL4 |
| deoxycytidine kinase activity | TK2 |
| ATP binding | BCKDK,MAPK4,PFKFB4,KITB,NLRC4,THRAP3,UBE2D2,PDXK,PGS1,TARS2 |
| drug binding | GRIK1,HMGCS1,PPARD,CHRNA3,MT3,SRP54,HTR1B,ADRB2,MTOR,DHODH |
| nucleoside kinase activity | UCK2A,UCK2,TK1,UCK1,UCK2B,DGUOK |
Interacting Protein
DCK has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DCK here. Most of them are supplied by our site. Hope this information will be useful for your research of DCK.
MED19;TFEC;RXRG;GOLM1;DDX19B;bosutinib
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References
- Zhuang, XM; Deng, JT; et al. Metabolism of novel anti-HIV agent 3-cyanomethyl-4-methyl-DCK by human liver microsomes and recombinant CYP enzymes. ACTA PHARMACOLOGICA SINICA 32:1276-1284(2011).
- Fong, WF; Shen, XL; et al. Methoxylation of 3 ',4 '-aromatic side chains improves P-glycoprotein inhibitory and multidrug resistance reversal activities of 7,8-pyranocoumarin against cancer cells. BIOORGANIC & MEDICINAL CHEMISTRY 16:3694-3703(2008).
