DAD1
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Official Full Name
Defender Against Cell Death 1 -
Overview
DAD1, the defender against apoptotic cell death, was initially identified as a negative regulator of programmed cell death in the temperature sensitive tsBN7 cell line. The DAD1 protein disappeared in temperature-sensitive cells following a shift to the nonpermissive temperature, suggesting that loss of the DAD1 protein triggered apoptosis. DAD1 is believed to be a tightly associated subunit of oligosaccharyltransferase both in the intact membrane and in the purified enzyme, thus reflecting the essential nature of N-linked glycosylation in eukaryotes. -
Synonyms
OST2;DAD1;Dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit DAD1;Oligosaccharyl transferase subunit DAD1;EC=2.4.1.119;Defender against cell death 1;AD-1;OTTHUMP00000164488;OTTHUMP00000239715;OTTHUMP00000239717;DAD-1;dolichyl-diphosphooligosaccharide--protein glycosyltransfe-rase subunit DAD1;EC 2.4.1.119;oligosaccharyltransferase 2 homolog
Recombinant Proteins
- Human
- Rhesus macaque
- Chicken
- Rat
- Zebrafish
- Rice
- Hordeum vulgare (Barley)
- Solanum lycopersicum (Tomato) (Lycopersicon esculentum)
- Sus scrofa (Pig)
- Citrus unshiu
- Bovine
- Picea mariana (Black spruce) (Abies mariana)
- Xenopus laevis
- Arabidopsis thaliana
- Malus Domestica
- Betula pendula
- Pongo Abelii
- Mesocricetus auratus
- Araneus ventricosus (Orbweaver spider) (Epeira ventricosa)
- Zea Mays
- Mus musculus
- E.coli
- Wheat Germ
- Mammalian Cell
- HEK293
- In Vitro Cell Free System
- E.coli expression system
- GST
- Non
- His
- His&Fc&Avi
Involved Pathway
DAD1 involved in several pathways and played different roles in them. We selected most pathways DAD1 participated on our site, such as Asparagine N-linked glycosylation,Metabolic pathways,Metabolism of proteins, which may be useful for your reference. Also, other proteins which involved in the same pathway with DAD1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Asparagine N-linked glycosylation | TRAPPC10,ST6GALNAC2,GNE,MPDU1B,ST8SIA2,MGAT4B,SLC35A1,SEC23A,AREG,NSFA |
| Protein processing in endoplasmic reticulum | ERLEC1,XBP1,CRYAB,CANX,SYVN1,SEC31B,SELS,DNAJC5,SAR1AB,PDIP5 |
| N-Glycan biosynthesis | MGAT1B,MGAT5,FUT8,MAN1A,ALG10B,ALG10,DPM2,ALG5,DPAGT1,B4GALT2 |
| Metabolism of proteins | PFDN5,KIFC3,RHBDL1,C8orf84,TIMM44,EIF5A2,PROZ,PFDN2,ARL2,CPA3 |
| Metabolic pathways | UGT1A6,GOT2,HYAL4,ACSL1,CBR1,DGKD,NMNAT3,ST3GAL3B,AMY2A2,THA1 |
| Post-translational protein modification | MUCL1,GALNTL2,SEC16B,PPP6C,C8orf84,DNAJC24,PREB,ARSJ,ADAMTS20,TRAPPC6B |
Protein Function
DAD1 has several biochemical functions, for example, contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity,contributes_to oligosaccharyl transferase activity. Some of the functions are cooperated with other proteins, some of the functions could acted by DAD1 itself. We selected most functions DAD1 had, and list some proteins which have the same functions with DAD1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| contributes_to oligosaccharyl transferase activity | DDOST |
| contributes_to dolichyl-diphosphooligosaccharide-protein glycotransferase activity | TUSC3,RPN2,STT3A,DDOST,RPN1,OSTC |
Interacting Protein
DAD1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with DAD1 here. Most of them are supplied by our site. Hope this information will be useful for your research of DAD1.
EPB41;HLA-B;IKBKE;q81v76_bacan;P
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