CYP1B1
-
Official Full Name
cytochrome P450, family 1, subfamily B, polypeptide 1 -
Overview
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008] -
Synonyms
CYP1B1;cytochrome P450, family 1, subfamily B, polypeptide 1;CP1B;GLC3A;CYPIB1;P4501B1;cytochrome P450 1B1;microsomal monooxygenase;xenobiotic monooxygenase;aryl hydrocarbon hydroxylase;flavoprotein-linked monooxygenase;cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile)
Recombinant Proteins
- Human
- Rhesus macaque
- Rat
- Mouse
- Zebrafish
- Dog
- Insect Cells
- Mammalian Cells
- Wheat Germ
- E.coli
- HEK293
- Yeast
- Non
- His
- GST
- His&Fc&Avi
Involved Pathway
CYP1B1 involved in several pathways and played different roles in them. We selected most pathways CYP1B1 participated on our site, such as AhR pathway,Arachidonic acid metabolism,Benzo(a)pyrene metabolism, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYP1B1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Biological oxidations | CYP2V1,FAM84B,AHCY,FDX1,CYP11B1,DPEP1,NAT2,MTRR,AS3MT,CYP2AD2 |
| Endogenous sterols | CYP21A2,CYP7A1,FDX1,CYP11A1,CYP46A1,CYP8B2,CYP11B1,CYP19A1,CYP27A1,POMCB |
| AhR pathway | CDKN1A,CDC37,JUND,EGFR,PTGES3,NQO1,AHR,AHRR,CYP1A2,JUN |
| Estrogen metabolism | COMT,ARSD,ARSE,CYP1A1,NQO1 |
| Benzo(a)pyrene metabolism | CYP3A4,FAM84B,AKR1A1,AKR1C2,CYP1A1,AKR1C4 |
| Cytochrome P450 - arranged by substrate type | CYP3C4,CYP4F12,CYP2AD2,POMCB,FDXR,CYP2S1,FDX1L,CYP3A4,CYP2A7,CYP2R1 |
| Chemical carcinogenesis | CYP2C70,UGT1A6,ADH1B,GSTM1,ALDH1A3,CYP3A5,MGST3,GSTA1,CCBL1,GSTT1 |
| Arachidonic acid metabolism | GPX1A,PLA2G4D,PLB1,CYP2C37,GGTLC1,PLA2G12B,GGT1A,CYP4F22,CYP4A11,CYP2AD2 |
Protein Function
CYP1B1 has several biochemical functions, for example, aromatase activity,heme binding,iron ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYP1B1 itself. We selected most functions CYP1B1 had, and list some proteins which have the same functions with CYP1B1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| aromatase activity | CYP2S1,CYP2C70,CYP2C38,CYP2A7,CYP4F12,CYP2C54,CYP2A12,CYP2C55,CYP2D9,CYP1D1 |
| iron ion binding | CYP3A7,CYP7A1,CH25HL2,CYP39A1,CYP8B1,CALR,CYP46A1,CYP4F2,CYP4F11,CYP17A2 |
| monooxygenase activity | CYP1A1,CYP3C4,CYP2K6,FOXRED2,CYP46A1.2,CYP2X10.2,COQ6,YWHAQB,CYP7A1A,CYP19A1B |
| oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen | CYP2K22,CYP2Y3,CYP2D9,CYP2P10,CYP2U1,CYP2D10,CYP2K18,CYP3A25,CYP2X8,CYP2B19 |
| oxygen binding | CYP2AD6,CYP2J6,CYP2C38,CYP2D6,HBG1,CYP2F1,HBAE3,CYP2N13,CYP2C18,CYP2J5 |
| heme binding | CYP20A1,CYP2F2,CYP2J2,CYP2J6,CYP3C1,PTGS2,CYP24A1,MB,HBAE3,CYB5R4 |
Interacting Protein
CYP1B1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYP1B1 here. Most of them are supplied by our site. Hope this information will be useful for your research of CYP1B1.
SAE1;fieF
Resources
Related Services
Related Products
References
- Chourasia, TK; Pang, YF; et al. The Catecholestrogen, 2-Hydroxyestradiol-17beta, Acts as a G Protein-Coupled Estrogen Receptor 1 (GPER/GPR30) Antagonist to Promote the Resumption of Meiosis in Zebrafish Oocytes. BIOLOGY OF REPRODUCTION 92:-(2015).
- Liu, Y; She, WM; et al. 3, 3 '-diindolylmethane alleviates steatosis and the progression of NASH partly through shifting the imbalance of Treg/Th17 cells to Treg dominance. INTERNATIONAL IMMUNOPHARMACOLOGY 23:489-498(2014).
