CYBB
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Official Full Name
cytochrome b-245, beta polypeptide -
Overview
Cytochrome b (-245) is composed of cytochrome b alpha (CYBA) and beta (CYBB) chain. It has been proposed as a primary component of the microbicidal oxidase system of phagocytes. CYBB deficiency is one of five described biochemical defects associated with chronic granulomatous disease (CGD). In this disorder, there is decreased activity of phagocyte NADPH oxidase; neutrophils are able to phagocytize bacteria but cannot kill them in the phagocytic vacuoles. The cause of the killing defect is an inability to increase the cells respiration and consequent failure to deliver activated oxygen into the phagocytic vacuole. [provided by RefSeq, Jul 2008] -
Synonyms
CYBB;cytochrome b-245, beta polypeptide;CGD;NOX2;AMCBX2;GP91-1;GP91PHOX;p91-PHOX;GP91-PHOX;cytochrome b-245 heavy chain;CGD91-phox;NADPH oxidase 2;p22 phagocyte B-cytochrome;cytochrome b558 subunit beta;cytochrome b(558) subunit beta;neutrophil cytochrome b 91 kDa polypeptide;heme-binding membrane glycoprotein gp91phox;superoxide-generating NADPH oxidase heavy chain subunit
Recombinant Proteins
- Human
- Zebrafish
- Chicken
- Sus scrofa (Pig)
- Mus musculus
- Yersinia pestis
- Bison bison (American bison) (Bos bison)
- Shigella flexneri
- E.coli
- Bovine
- E.coli
- Mammalian Cells
- Wheat Germ
- HEK293
- Yeast
- His
- GST
- Non
- His&SUMO
Involved Pathway
CYBB involved in several pathways and played different roles in them. We selected most pathways CYBB participated on our site, such as Adaptive Immune System,Antigen processing-Cross presentation,Class I MHC mediated antigen processing &, which may be useful for your reference. Also, other proteins which involved in the same pathway with CYBB were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| HIF-1 signaling pathway | EGLN2,EGLN3,AHA-1 |
| presentation | RNF144B,RBCK1,BLMH,ASB3,UBE2V1,RNF220,GAN,FBXO3,CYBA,RNF34 |
| Cross-presentation of particulate exogenous antigens (phagosomes) | CYBA |
| Class I MHC mediated antigen processing & | DZIP3,B2ML,RNF123,TRIM63,STUB1,KLHL21,ATG7,UBE2V2,FCGR1B,CTSS |
| Immune System | RNF182,HCST,LY86,S100B,HAVCR2,CD200R2,CRP,ASB17,NLRP3,IFIT8 |
| Adaptive Immune System | SPSB1,ASB9,CRTAM,RAET1E,RAPGEF4,FRS2B,SEC61B,IGKV1-5,TRIM11,KLRF1 |
| Leukocyte transendothelial migration | F11R,MAPK12,CLDN3,MMP2,PRKCG,CLDN6,MYL2,EZR,PXN,MYL7 |
| Antigen processing-Cross presentation | CTSL2,CTSS,FCGR1B,CTSL1,CD207,SEC61B,CYBA |
| Osteoclast differentiation | LILRA3,MAPK1,ACP5,MAPK11,CSF1,FCGR3B,LILRA2,MAPK9,IFNGR2,AKT1 |
Protein Function
CYBB has several biochemical functions, for example, contributes_to electron carrier activity,flavin adenine dinucleotide binding,heme binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CYBB itself. We selected most functions CYBB had, and list some proteins which have the same functions with CYBB. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| heme binding | SDHDB,CYBA,PGRMC2,CYP2P6,CYP2U1,CYP2K16,CYP26A1,CYP46A1.1,CYP2A4,CYP19A1A |
| protein binding | HTR3C,EPB49,RCAN3,RORC,TAF1A,ARHGAP33,PEA15,NR3C1,TBX1,FKBP5 |
| superoxide-generating NADPH oxidase activity | SH3PXD2AA,NCF1,NOX3,NOX4,NOX1,NOX5,PAX2 |
| metal ion binding | MDP1,SALL2,ATP8B5,PDE6B,DGKAA,ESR2A,ESR2B,HSPB11,SUCLA2,PPM1BA |
| flavin adenine dinucleotide binding | ACOXL,AIFM3,KMO,DMGDH,AOX1,DUS3L,DPYD,MAOB,FMO2,POR |
| voltage-gated ion channel activity | KCNA6A,CLCNKB,CLCN3,KCNJ11L,CACNG2B,CACNA1C,KCNC1A,CACNA1BA,KCNJ2A,CX35B |
| contributes_to superoxide-generating NADPH oxidase activity | CYBA |
| protein heterodimerization activity | TAF9,NFYBA,UGT1A1,BIRC5,HIST2H2AA4,TAF6L,SOX9,ZHX3,MID1,CAPN2 |
Interacting Protein
CYBB has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CYBB here. Most of them are supplied by our site. Hope this information will be useful for your research of CYBB.
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References
- Sonati, T; Reimann, RR; et al. The toxicity of antiprion antibodies is mediated by the flexible tail of the prion protein. NATURE 501:102-+(2013).
- Lee, WI; Huang, JL; et al. Patients with inhibitory and neutralizing auto-antibodies to interferon-gamma resemble the sporadic adult-onset phenotype of Mendelian Susceptibility to. Mycobacterial Disease (MSMD) lacking Bacille Calmette-Guerin (BCG)-induced diseases. IMMUNOBIOLOGY 218:762-771(2013).
