CRKL
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Official Full Name
v-crk sarcoma virus CT10 oncogene homolog (avian)-like -
Overview
CrkL, a 39 kDa adaptor protein, has a key regulatory role in hematopoietic cells. CrkL has one SH2 and two SH3 domains, with 60% homology to CrkII (1). The amino-terminal SH3 domain of CrkL binds proteins such as C3G, SOS, PI3K, c-Abl and BCR/Abl. The SH2 -
Synonyms
CRKL;v-crk sarcoma virus CT10 oncogene homolog (avian)-like;v crk avian sarcoma virus CT10 oncogene homolog like;crk-like protein
Recombinant Proteins
- Human
- Rhesus macaque
- Zebrafish
- Rat
- Mouse
- E.coli
- Mammalian Cell
- Wheat Germ
- Sf9 Insect Cell
- HEK293
- In Vitro Cell Free System
- HEK293T
- His
- GST
- Non
- His&Strep
- His&Fc&Avi
- Myc&DDK
Involved Pathway
CRKL involved in several pathways and played different roles in them. We selected most pathways CRKL participated on our site, such as B Cell Receptor Signaling Pathway,Bacterial invasion of epithelial cells,Chemokine signaling pathway, which may be useful for your reference. Also, other proteins which involved in the same pathway with CRKL were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Chemokine signaling pathway | PF4V1,PARD3,CCR9,GNG4,NRAS,PPBP,CXCR6,CCL15,AMCF-II,AKT1 |
| B Cell Receptor Signaling Pathway | SYK,RAC3,Cd79a,PLCG2,CDK7,GSK3AB,ITPR2,MALT1,CTNNB2,IKBKG |
| Cytokine Signaling in Immune system | MAP3K8,XAF1,IFI6,DAB2IPB,SPTB,ARIH1,ARIH1L,HERC5,CRK,TNFRSF13C |
| Chronic myeloid leukemia | GRB2,TGFB3,NRAS,CBL,HDAC2,CBLB,SMAD4,CDK6,MAPK1,PIK3CG |
| Downstream signal transduction | AGO2,PTPRA,DUSP7,SPTBN1,FGF8B,FRS3,SPTA1,FGF10B,MARK3,DUSP9 |
| EGFR1 Signaling Pathway | STXBP1A,SH2D3C,MTA2,APPL2,PLSCR1,CEBPA,PITPNAA,RALBP1,SPRY2,RBBP7 |
| Bacterial invasion of epithelial cells | CBL,SEPT6,PIK3CG,SEPT2,ARPC4,BCAR1,SRC,ACTG1,SEPT9,RAC1 |
| EPHA forward signaling | EFNA5,EFNA3,EFNA2,ARHGEF15,EFNA1,EPHA2,BLK |
Protein Function
CRKL has several biochemical functions, for example, SH3/SH2 adaptor activity,poly(A) RNA binding,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CRKL itself. We selected most functions CRKL had, and list some proteins which have the same functions with CRKL. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| poly(A) RNA binding | SUGP2,HARS2,SNRPD2,HIST1H4K,REXO4,ALDH18A1,GNL3,DDX56,NCOA5,XRN2 |
| signal transducer activity | STAT2,GPR132,OLFR49,EMR4,TAAR14G,OLFCJ1,OR115-6,OLFCS1,TAAR1B,OLFR507 |
| SH3/SH2 adaptor activity | SH2D1A,GAB1,HSH2D,SH3BGRL,STAM,EPS8,SH2D3A,CD28,NCK1,GRB10 |
| protein binding | ACY3,TAF1D,TRIM37,PTGIS,ERLIN1,LARP4B,PRAC,CALR,COA3,GFI1 |
Interacting Protein
CRKL has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CRKL here. Most of them are supplied by our site. Hope this information will be useful for your research of CRKL.
CBL;GAB1;EGFR;Kcnma1
Resources
Research Area
Apoptosis Adaptor ProteinsAdaptor Proteins
Adaptor Proteins in the Akt Pathway
Focal Adhesion Adaptor and Scaffold Proteins
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References
- Lv, SZ; Zhang, J; et al. Nucleolin Promotes TGF-beta Signaling Initiation via TGF-beta Receptor I in Glioblastoma. JOURNAL OF MOLECULAR NEUROSCIENCE 55:1-6(2015).
- Aspinall-O'Dea, M; Pierce, A; et al. Antibody-based detection of protein phosphorylation status to track the efficacy of novel therapies using nanogram protein quantities from stem cells and cell lines. NATURE PROTOCOLS 10:149-168(2015).
