COL2A1
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Official Full Name
collagen, type II, alpha 1 -
Overview
Type II collagen is the major collagen found in cartilage and is expressed in two forms: IIA and IIB. Type IIA procollagen contains an N-terminal 69 amino acid, cysteine-rich globular domain that is encoded by exon 2. Type IIB procollagen is synthesized by mature chondrocytes in cartilage while Type IIA procollagen is synthesized by chondroprogenitor cells. The Type IIA N-propeptide (PIIANP) has been postulated to play a role in chondrogensis. Type IIA procollagen has been found to be synthesized by osteoarthritic chondrocytes in diseased cartilage and may serve as a specific arthritis biomarker that reflects an attempt by the chondrocytes to repair diseased cartilage. -
Synonyms
ANFH;AOM;COL11A3;SEDC;alpha-1 type II collagen;cartilage collagen;chondrocalcin;collagen II, alpha-1 polypeptide;collagen alpha-1(II) chain;COL2A1
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Rabbit
- Bovine
- HEK293
- E.coli
- CHO
- Mammalian Cell
- Wheat Germ
- Human Cell
- E. coli
- Fetal bovine articular cartilage
- Chick sternum
- Human joint
- Human Nasal Septum
- In Vitro Cell Free System
- His
- GST
- His&GST
- Non
- His&Fc&Avi
| Cat.# | Product name | Source (Host) | Species | Tag | Protein Length | Price |
|---|---|---|---|---|---|---|
| COL2A1-3929H |
Recombinant Human COL2A1 protein(Asp1242-Leu1487), His-tagged
|
HEK293 | Human | His | Asp1242-Leu1487 | |
| COL2A1-11432H | Recombinant Human COL2A1, His-tagged | E.coli | Human | His | C-288a.a. | |
| COL2A1-26H |
Active Recombinant Human COL2A1 protein, His-tagged
|
CHO | Human | His | 26-266;957-1487 a.a. |
|
| COL2A1-1521R | Recombinant Rat COL2A1 Protein | Mammalian Cell | Rat | His |
|
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| COL2A1-1649H | Recombinant Human COL2A1 Protein, GST-tagged | Wheat Germ | Human | GST |
|
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| COL2A1-181H | Recombinant Human COL2A1 | Mammalian Cell | Human | His |
|
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| Col2a1-36M | Recombinant Mouse Col2a1 protein, His-tagged | HEK293 | Mouse | His |
|
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| COL2A1-3733M | Recombinant Mouse COL2A1 Protein | Mammalian Cell | Mouse | His |
|
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| COL2A1-5996C | Recombinant Chicken COL2A1 | Mammalian Cell | Chicken | His |
|
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| Col2a1-7924M | Recombinant Mouse Col2a1 protein, His-tagged | E.coli | Mouse | His | Gly677~Ala817 |
|
| Col2a1-7925R | Recombinant Rat Col2a1 protein, His-tagged | E.coli | Rat | His | Lys1226~Tyr1331 |
|
| COL2A1-7926R | Recombinant Rabbit COL2A1 protein, His & GST-tagged | E.coli | Rabbit | His&GST | Leu1259~Val1449 |
|
| COL2A1-2063HCL | Recombinant Human COL2A1 cell lysate | Human Cell | Human | Non | 1242-1487 a.a. |
|
| COL2A1-1178R | Recombinant Rat COL2A1 Protein, His (Fc)-Avi-tagged | HEK293 | Rat | His&Fc&Avi |
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| COL2A1-1178R-B | Recombinant Rat COL2A1 Protein Pre-coupled Magnetic Beads | HEK293 | Rat |
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| Col2a1-1278M | Recombinant Mouse Col2a1 protein, His-tagged | E. coli | Mouse | His | Thr1307~Thr1383 |
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| Col2a1-1279M | Recombinant Mouse Col2a1 Protein, His-tagged | E.coli | Mouse | His | Asp1242-Leu1487 |
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| Col2a1-1280M | Recombinant Mouse Col2a1 protein, His-tagged | HEK293 | Mouse | His | Asp1242~Leu1487 |
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| COL2a1-1284H | Recombinant Human COL2a1 protein, His-tagged | E.coli | Human | His | Gln26~Ala181 |
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| COL2A1-13B | Native Bovine COL2A1 Protein | Fetal bovine articular cartilage | Bovine |
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| COL2A1-14B | Native Bovine COL2A1 Protein | Fetal bovine articular cartilage | Bovine |
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| COL2A1-15C | Native Chicken COL2A1 Protein | Chick sternum | Chicken |
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| COL2A1-1647H | Native Human COL2A1 Protein | Human joint | Human | Non |
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| COL2A1-1648H | Native Human COL2A1 Protein | Human Nasal Septum | Human | Non |
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| COL2A1-16C | Native Chicken COL2A1 Protein | Chick sternum | Chicken |
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| COL2A1-1763H | Recombinant Human COL2A1 Protein (Ser1386-Pro1467), N-His tagged | E.coli | Human | His | Ser1386-Pro1467 |
|
| COL2A1-1861M | Recombinant Mouse COL2A1 Protein, His (Fc)-Avi-tagged | HEK293 | Mouse | His&Fc&Avi |
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| COL2A1-1861M-B | Recombinant Mouse COL2A1 Protein Pre-coupled Magnetic Beads | HEK293 | Mouse |
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| COL2A1-2137HF | Recombinant Full Length Human COL2A1 Protein, GST-tagged | In Vitro Cell Free System | Human | GST | Full L. 268 amino acids |
|
| COL2A1-2155H | Recombinant Human COL2A1 Protein, His-tagged | E.coli | Human | His | Trp1337-Leu1487 |
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| COL2A1-2156H | Recombinant Human COL2A1 Protein, His-tagged | E.coli | Human | His | Asp1242-Leu1487 |
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| COL2A1-2712H | Recombinant Human COL2A1 Protein, His (Fc)-Avi-tagged | HEK293 | Human | His&Fc&Avi |
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| COL2A1-2712H-B | Recombinant Human COL2A1 Protein Pre-coupled Magnetic Beads | HEK293 | Human |
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| COL2a1-3325M | Recombinant Mouse COL2a1 protein, His-GST-tagged | E.coli | Mouse | His&GST | Gly677~Ala817 |
|
Involved Pathway
COL2A1 involved in several pathways and played different roles in them. We selected most pathways COL2A1 participated on our site, such as Amoebiasis,Assembly of collagen fibrils and other multimeric structures,Collagen biosynthesis and modifying enzymes, which may be useful for your reference. Also, other proteins which involved in the same pathway with COL2A1 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Amoebiasis | GNAS,NFKB1,IL1B,RAB7B,TNF,C9,LAMB3,PIK3CG,MUC2,C8A |
| Extracellular matrix organization | COL13A1,MGC174152,FN1B,CRTAP,ADAMTS2,SERPINH1B,ELANE,MMP17,COL4A4,MGC174857 |
| Focal adhesion | THBS1,PPP1R12A,DOCK1,PXN,MAPK1,FN1,VAV3,XIAP,IGF1,VTN |
| ECM-receptor interaction | ITGA5,COL5A1,VTNA,THBS3A,COMP,ITGA3,ITGA4,COL6A3,ITGB1A,Reln |
| Collagen biosynthesis and modifying enzymes | COL13A1,COL9A1A,PCOLCE,LEPREL2,TLL1,COL19A1,COL5A1,SERPINH1B,COL1A2,LEPREL1 |
| Collagen formation | LEPREL1,COL8A1,COL28A1,CTSS,COL13A1,TLL1,BMP1A,COL19A1,COL28A1D,COL4A6 |
| Assembly of collagen fibrils and other multimeric structures | COL11A1B,COL1A1,COL5A1,COL8A1A,COL10A1,COL5A3B,COL6A3,COL8A2,COL4A4,LOXL2 |
| Endochondral Ossification | COL10A1,FRZB,NKX3-2,NKX3.2,PTH,IFT88,RUNX2A,RUNX3,ADAMTS4,PTHLH |
Protein Function
COL2A1 has several biochemical functions, for example, extracellular matrix structural constituent conferring tensile strength,identical protein binding,metal ion binding. Some of the functions are cooperated with other proteins, some of the functions could acted by COL2A1 itself. We selected most functions COL2A1 had, and list some proteins which have the same functions with COL2A1. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| identical protein binding | IGF1R,ATG16L1,PRDX1,AGXT2L1,BNIP3L,ACTN2,DAPK2,NDE1,UBQLN1,PTS |
| platelet-derived growth factor binding | COL1A1,PDGFRB,Pdgfa&Pdgfb,COL3A1,COL4A1,COL6A1,COL1A2,PDGFA,COL5A1,PDGFRA |
| extracellular matrix structural constituent conferring tensile strength | COL9A3,COL9A1 |
| metal ion binding | ZNF177,CYP46A1.3,ZNF763,CDKAL1,ADCY7,HDAC9,ZFR,ZBED1,POLA1,Amy1 |
Interacting Protein
COL2A1 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with COL2A1 here. Most of them are supplied by our site. Hope this information will be useful for your research of COL2A1.
COCH;RELA;HYAL1
Resources
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References
- Tillgren, V; Ho, JCS; et al. The Novel Small Leucine-rich Protein Chondroadherin-like (CHADL) Is Expressed in Cartilage and Modulates Chondrocyte Differentiation. JOURNAL OF BIOLOGICAL CHEMISTRY 290:918-925(2015).
- Li, J; Xie, ZG; et al. Calcitonin treatment is associated with less severe osteoarthritis and reduced toll-like receptor levels in a rat model. JOURNAL OF ORTHOPAEDIC SCIENCE 19:1019-1027(2014).
