CD33

  • Official Full Name

    CD33 CD33 molecule

  • Overview

    CD33 is a 67-kDa transmembrane glycoprotein that contains one V-set and one C2-set Ig-like domain6. It is a biomarker and therapeutic target for acute myeloid leukemia (AML). The recruitment of SHP-1 and SHP-2 by CD33 results in inhibition of tyrosine phosphorylation and Ca2+ mobilization. CD33 expression is assumed to be restricted to the myeloid lineage of immune cells. Thus, it is highly expressed on myeloid-committed cells of the bone marrow and circulating monocytes. CD33 expression is down-regulated to low levels on peripheral granulocytes and resident macrophages, and it is constitutive on DC. This expression pattern suggests a role of CD33 on myeloid differentiation and cellular function of monocyte and DC

  • Synonyms

    CD33;CD33 molecule;CD33 antigen (gp67);myeloid cell surface antigen CD33;FLJ00391;p67;sialic acid binding Ig like lectin 3;SIGLEC 3;SIGLEC3;gp67;sialic acid binding Ig-like lectin 3;sialic acid-binding Ig-like lectin 3;SIGLEC-3

Recombinant Proteins

  • Human
  • Monkey
  • Mouse
  • Cynomolgus
  • Rat
  • Mammalian cells
  • Human Cell
  • E.coli
  • HEK293
  • CHO cells
  • HEK293 cells
  • NS0
  • Wheat Germ
  • Human Cells
  • Insect Cell
  • HEK293T
  • In Vitro Cell Free System
  • HEK293F
  • E.coli expression system
  • Fc
  • GST
  • Non
  • His
  • His&Fc
  • His&Avi
  • Fc&Avi
  • Flag
  • mFc
  • His&Myc&SUMO
  • Myc&DDK
  • lIgG2b
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CD33-176HAF488 Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 488 conjugated Mammalian cells Human Fc
CD33-176HAF555 Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 555 conjugated Mammalian cells Human Fc
CD33-176HAF647 Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 647 conjugated Mammalian cells Human Fc
CD33-176HF Active Recombinant Human CD33 Protein, Fc-tagged, FITC conjugated Mammalian cells Human Fc
CD33-234H Recombinant Human CD33, His tagged Human Cell Human Fc 1-259 a.a.
CD33-10946H Recombinant Human CD33, GST-tagged E.coli Human GST 49-259a.a.
CD33-313H Recombinant Human CD33, Fc tagged Human Cell Human Non 1-259 a.a.
CD33-459H Recombinant Human CD33 Molecule, Fc Chimera HEK293 Human Fc
CD33-181CAF488 Recombinant Cynomolgus CD33 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Monkey His Met1-Gly248， 244
CD33-181CAF555 Recombinant Cynomolgus CD33 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Monkey His Met1-Gly248， 244
CD33-181CAF647 Recombinant Cynomolgus CD33 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Monkey His Met1-Gly248， 244
CD33-181CF Recombinant Cynomolgus CD33 Protein, His-tagged, FITC conjugated HEK293 Monkey His Met1-Gly248， 244
CD33-234HAF488 Recombinant Human CD33 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Human His 253
CD33-234HAF555 Recombinant Human CD33 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Human His 253
CD33-234HAF647 Recombinant Human CD33 protein, His-tagged, Alexa Fluor 647-Labeled HEK293 Human His Asp 18 - His 259
CD33-234HF Recombinant Human CD33 Protein, His-tagged, FITC conjugated HEK293 Human His 253
CD33-313HAF488 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc 476
CD33-313HAF555 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc 476
CD33-313HAF647 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc 476
CD33-313HF Recombinant Human CD33 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc 476
CD33-459HA Recombinant Human CD33 protein, Fc-tagged, APC labeled HEK293 Human Fc
CD33-459HAF488 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Human Fc
CD33-459HAF555 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Human Fc
CD33-459HAF647 Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Human Fc
CD33-459HF Recombinant Human CD33 Protein, Fc-tagged, FITC conjugated HEK293 Human Fc
CD33-459HP Recombinant Human CD33 protein, Fc-tagged, R-PE labeled HEK293 Human Fc
Cd33-5169MAF488 Recombinant Mouse Cd33 Protein, His-tagged, Alexa Fluor 488 conjugated HEK293 Mouse His 235
Cd33-5169MAF555 Recombinant Mouse Cd33 Protein, His-tagged, Alexa Fluor 555 conjugated HEK293 Mouse His 235
Cd33-5169MAF647 Recombinant Mouse Cd33 Protein, His-tagged, Alexa Fluor 647 conjugated HEK293 Mouse His 235
Cd33-5169MF Recombinant Mouse Cd33 Protein, His-tagged, FITC conjugated HEK293 Mouse His 235
Cd33-6889MAF488 Recombinant Mouse Cd33 Antigen Protein, Fc-tagged, Alexa Fluor 488 conjugated HEK293 Mouse Fc 465
Cd33-6889MAF555 Recombinant Mouse Cd33 Antigen Protein, Fc-tagged, Alexa Fluor 555 conjugated HEK293 Mouse Fc 465
Cd33-6889MAF647 Recombinant Mouse Cd33 Antigen Protein, Fc-tagged, Alexa Fluor 647 conjugated HEK293 Mouse Fc 465
Cd33-6889MF Recombinant Mouse Cd33 Antigen Protein, Fc-tagged, FITC conjugated HEK293 Mouse Fc 465
CD33-833HAF488 Recombinant Human CD33 Protein, Fc/His-tagged, Alexa Fluor 488 conjugated HEK293 Human His&Fc
CD33-833HAF555 Recombinant Human CD33 Protein, Fc/His-tagged, Alexa Fluor 555 conjugated HEK293 Human His&Fc
CD33-833HAF647 Recombinant Human CD33 Protein, Fc/His-tagged, Alexa Fluor 647 conjugated HEK293 Human His&Fc
CD33-833HF Recombinant Human CD33 Protein, Fc/His-tagged, FITC conjugated HEK293 Human His&Fc
CD33-176H Active Recombinant Human CD33, Fc Chimera Mammalian cells Human Fc
CD33-675H Active Recombinant Human CD33, Fc-tagged, Biotinylated Human Cell Human Fc 18-260 a.a.
CD33-051H Active Recombinant Human CD33 protein, His-Avi-tagged, Biotinylated CHO cells Human His&Avi Met17-His259
CD33-052H Active Recombinant Human CD33 protein, Fc/Avi-tagged, Biotinylated HEK293 cells Human Fc&Avi Met17-His259
CD33-25H Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor® 488 conjugated NS0 Human Fc
CD33-26H Active Recombinant Human CD33 Protein, Fc-tagged, Alexa Fluor® 647 conjugated NS0 Human Fc
CD33-27H Active Recombinant Human CD33 Protein, Fc-tagged, Atto 488 conjugated NS0 Human Fc
CD33-28H Active Recombinant Human CD33 Protein, Fc-tagged, Atto 647N conjugated NS0 Human Fc
CD33-0790H Recombinant Human CD33 Protein Wheat Germ Human Non
CD33-0791H Recombinant Human CD33 Protein, GST-Tagged Wheat Germ Human GST
CD33-181C Recombinant Cynomolgus CD33, His-tagged Human Cell Cynomolgus His Met1-Gly248
CD33-267H Recombinant Human CD33 protein, His-tagged HEK293 Human His 185
CD33-268H Active Recombinant Human CD33 protein, Avi-His-tagged, Biotinylated HEK293 Human His&Avi Asp 18 - His 259
CD33-487H Recombinant Human CD33 molecule, His-tagged E.coli Human His 18-259 a.a.
CD33-5088H Recombinant Human CD33, His-tagged E.coli Human His
Cd33-5169M Recombinant Mouse Cd33 protein(Met1-Glu240), His-tagged HEK293 Mouse His Met1-Glu240
Cd33-586M Recombinant Mouse Cd33 protein, His-tagged E.coli Mouse His Asp18~Glu240
Cd33-6889M Recombinant Mouse CD33 Antigen, Fc-tagged Human Cell Mouse Fc 465aa
CD33-7815H Active Recombinant Human CD33 protein, His-tagged HEK293 Human His Asp 18 - His 259
CD33-833H Recombinant Human CD33 Protein, Fc/His-tagged HEK293 Human His&Fc
CD33-1808MCL Recombinant Mouse CD33 cell lysate Human Cell Mouse Non
CD33-978HCL Recombinant Human CD33 cell lysate Human Cell Human Non
CD33-013M CD33-coupled magnetic beads Human
CD33-031HG Active GMP Recombinant Human CD33 protein HEK293 Human DNA sequence encoding Human CD33(AAH28152.1) was expressed with His tag at the C-terminal.
CD33-043H Recombinant Human CD33 Protein, ECD, Tag Free, Biotinylated HEK293 Human Non ECD
CD33-0704H Recombinant Human CD33 protein, His-tagged, APC-Labeled HEK293 Human His 18-259 a.a.
CD33-0705R Active Recombinant Rat CD33 protein, His-tagged HEK293 Rat His 18-240 a.a.
CD33-0706H Active Recombinant Human CD33 protein, Fc-tagged HEK293 Human Fc 18-259 a.a.
CD33-0707M Recombinant Mouse CD33 protein, His-tagged HEK293 Mouse His 18-240 a.a.
CD33-0708C Recombinant Cynomolgus CD33 protein, His-tagged HEK293 Cynomolgus His 36-248 a.a.
CD33-0709H Active Recombinant Human CD33 protein, Fc-Avi-tagged, Biotinylated HEK293 Human Fc&Avi 18-259 a.a.
CD33-0710H Active Recombinant Human CD33 protein, Fc-tagged, FITC-Labeled HEK293 Human Fc 18-259 a.a.
CD33-0711H Active Recombinant Human CD33 protein, His-tagged, FITC-Labeled HEK293 Human His 18-259 a.a.
CD33-0712H Recombinant Human CD33 protein, Fc-tagged HEK293 Human Fc 18-132 a.a.
CD33-0715H Active Recombinant Human CD33 protein, Fc-tagged HEK293 Human Fc 18-259 a.a.
CD33-1081C Recombinant Cynomolgus CD33 Protein (Met1-Gly248), His-tagged, Biotinylated HEK293 Cynomolgus His Met1-Gly248
CD33-139HFL Active Recombinant Full Length Human CD33 Protein, C-Flag-tagged Mammalian cells Human Flag Full L.
CD33-152H Recombinant Human CD33 Protein, DYKDDDDK-tagged Human Cells Human Flag
CD33-176HA Recombinant Human CD33 protein, Fc-tagged, APC labeled Mammalian cells Human Fc
CD33-176HP Recombinant Human CD33 protein, Fc-tagged, R-PE labeled Mammalian cells Human Fc
CD33-190H Recombinant Human CD33 Protein, His-tagged E.coli Human His
CD33-205H Recombinant Human CD33 Protein, His-tagged HEK293 Human His Thr142-Thr232
CD33-234HB Recombinant Human CD33 protein, His-tagged, Biotinylated HEK293 Human His 1-259 a.a.
CD33-2357H Recombinant Human CD33 protein(Met1-His259), mFc-tagged HEK293 Human mFc Met1-His259
CD33-240H Recombinant Human CD33 Protein, hIgG-His-tagged Insect Cell Human His&Fc 18-259aa
CD33-2568H Recombinant Human CD33 protein, His-Avi-tagged HEK293 Human His&Avi Asp18-His259
CD33-265H Recombinant Human CD33 molecule Protein, Tag Free HEK293 Human Non 18-259aa
CD33-2662H Recombinant Human CD33 protein, His-SUMO & Myc-tagged E.coli Human His&Myc&SUMO 18-259aa
CD33-2680H Active Recombinant Human CD33 protein, hFc&His-tagged HEK293 Human His&Fc Asp18-His259
CD33-2933H Recombinant Human CD33 Protein, Myc/DDK-tagged, C13 and N15-labeled HEK293T Human Myc&DDK
CD33-29H Recombinant Human CD33 Protein (ECD), Fc-His-tagged(C-ter) HEK293 Human His&Fc Asp18-His259
CD33-3097H Recombinant Human CD33 Protein, MYC/DDK-tagged HEK293 Human Myc&DDK
CD33-3161HF Recombinant Full Length Human CD33 Protein In Vitro Cell Free System Human Full L. 836 amino acids
CD33-3162HF Recombinant Full Length Human CD33 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 364 amino acids
CD33-342H Active Recombinant Human CD33 Protein, LIgG2b Fc-tagged, low endotoxin HEK293 Human lIgG2b Asp 18 - His 259
CD33-345H Recombinant Human CD33 protein, hFc-tagged HEK293 Human Fc Asp18-His259
CD33-37H Recombinant Human CD33 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CD33-37H-B Recombinant Human CD33 Protein Pre-coupled Magnetic Beads HEK293 Human
CD33-429M CD33 protein-coupled magnetic MicroBeads Human
CD33-443H Recombinant Human CD33 Protein, His-tagged HEK293 Human His 364
CD33-444H Recombinant Human CD33 Protein, Fc-tagged HEK293 Human Fc 364
CD33-4673H Active Recombinant Human CD33 Protein, His-tagged, Site-specific PE-Labeled HEK293 Human His Asp 18 - His 259
CD33-501H Recombinant Human CD33 Protein (Asp18-His259), C-hFc and 6×His-tagged HEK293 Human His&Fc Asp18-His259
CD33-5341H Recombinant Human CD33 Protein (Met1-His259), C-His tagged Mammalian cells Human His Met1-His259
CD33-551H Recombinant Human CD33 Protein (Met1-His259) HEK293 Human Non Met1-His259
CD33-552H Recombinant Human CD33 protein (Met1-His259) HEK293 Human 1-259 a.a.
CD33-5833M Active CD33 protein-coupled magnetic Beads HEK293 Human Asp 18 - His 259
CD33-670H Recombinant Human CD33 Protein, His-tagged HEK293F Human His Asp18-His259
Cd33-671R Recombinant Rat Cd33 Protein, His-tagged E.coli Rat His Pro26-Cys298
Cd33-6889MA Recombinant Mouse Cd33 protein, Fc-tagged, APC labeled HEK293 Mouse Fc
Cd33-6889MP Recombinant Mouse Cd33 protein, Fc-tagged, R-PE labeled HEK293 Mouse Fc
Cd33-832M Recombinant Mouse Cd33 Protein, MYC/DDK-tagged HEK293T Mouse Myc&DDK
CD33-833HA Recombinant Human CD33 protein, Fc/His-tagged, APC labeled HEK293 Human His&Fc
CD33-833HP Recombinant Human CD33 protein, Fc/His-tagged, R-PE labeled HEK293 Human His&Fc
CD33-835M Recombinant Mouse CD33 Protein (Met1-Glu240) HEK293 Mouse Non Met1-Glu240
CD33-8465M Whole Blood CD33 protein-coupled magnetic MicroBeads Human
RFL3999HF Recombinant Full Length Human Myeloid Cell Surface Antigen Cd33(Cd33) Protein, His-Tagged E.coli expression system Human His Full L. Full Length of Mature Protein (18-364)

    Involved Pathway

    CD33 involved in several pathways and played different roles in them. We selected most pathways CD33 participated on our site, such as Hematopoietic cell lineage, which may be useful for your reference. Also, other proteins which involved in the same pathway with CD33 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Hematopoietic cell lineage CD1A,CD8A,ITGA2,ITGA4,CD7,CD44,IL11RA2,IL1R1,CD3D,IL1B

    Protein Function

    CD33 has several biochemical functions, for example, carbohydrate binding,protein binding,receptor activity. Some of the functions are cooperated with other proteins, some of the functions could acted by CD33 itself. We selected most functions CD33 had, and list some proteins which have the same functions with CD33. You can find most of the proteins on our site.

    Function Related Protein
    receptor activity CD200,GRIA4B,OGFRL2,SMAGP,STRA6,CALCR,CD86,EPHB6,VMN1R49,PVRL3B
    protein binding CLDN18,Rhox5,KARS,BAZ1B,TDP1,ZC3H10,NAA16,TRIM23,KAT8,KISS1
    carbohydrate binding SIGLEC14,FCN3,CLEC11A,GALNT1,PVRL1,CHIA,UAP1,GFPT2,GALNT13,REG3A

    Interacting Protein

    CD33 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CD33 here. Most of them are supplied by our site. Hope this information will be useful for your research of CD33.

    PTPN6;PTPN11;KRT31;KRT40;HERC3

    Resources

    Research Area

    Cancer Drug Targets
    ITIM/ITAM Immunoreceptors and Related Molecules
    Myeloid Lineage Markers
    CD Antigen (Hematopoietic Stem Cell Markers)
    Myeloid Cell
    Macrophage Markers
    Monocyte Markers
    Ig-type Lectins
    Dendritic Cell Activation
    Dendritic Cell ITIM/ITAM Immunoreceptors
    MDSC Phenotyping - Positive Markers
    CAR-T Cell Therapy Targets

    References

    • Loke, J; Khan, JN; et al. Mylotarg has potent anti-leukaemic effect: a systematic review and meta-analysis of anti-CD33 antibody treatment in acute myeloid leukaemia. ANNALS OF HEMATOLOGY 94:361-373(2015).
    • Xu, LM; Zhang, Y; et al. Bi-specific antibodies with high antigen-binding affinity identified by flow cytometry. INTERNATIONAL IMMUNOPHARMACOLOGY 24:463-473(2015).

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