CALCA
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Official Full Name
calcitonin-related polypeptide alpha -
Overview
This gene encodes the peptide hormones calcitonin, calcitonin gene-related peptide and katacalcin by tissue-specific alternative RNA splicing of the gene transcripts and cleavage of inactive precursor proteins. Calcitonin is involved in calcium regulation and acts to regulate phosphorus metabolism. Calcitonin gene-related peptide functions as a vasodilator while katacalcin is a calcium-lowering peptide. Multiple transcript variants encoding different isoforms have been found for this gene. -
Synonyms
Alpha CGRP;CALC 1;CALC A;CALC1;CALCA;Calcitonin related polypeptide alpha;CGRP 1;CGRP;CGRP I;CGRP1;CGRPI;CT;Katacalcin;KC;MGC126648
Recombinant Proteins
- Human
- Rat
- Mouse
- Chicken
- Zebrafish
- Dog
- Canine
- Horse
- Porcine
- Eel
- E.coli
- E. coli
- Human
- Wheat Germ
- Mammalian Cell
- HEK293
- HEK293 cells
- Mammalian cells
- Yeast
- In Vitro Cell Free System
- HEK293T
- GST
- N-GST
- Non
- His
- mFc
- His&GST
- N-His
- His&Fc&Avi
- His&SUMO
- N-His-sumostar
- Myc&DDK
Involved Pathway
CALCA involved in several pathways and played different roles in them. We selected most pathways CALCA participated on our site, such as Amyloid formation,Calcitonin-like ligand receptors,Class B/2 (Secretin family receptors), which may be useful for your reference. Also, other proteins which involved in the same pathway with CALCA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Calcitonin-like ligand receptors | ADM,ADM2,RAMP1,RAMP2,RAMP3,CALCB,ADM2A,CALCRL |
| Class B/2 (Secretin family receptors) | CALCB,ADM,SETD6,PTHLH,PTH,RAMP2,PTH2,EMR4,ADCYAP1R1,PTHLHA |
| GPCR ligand binding | PTHLH,PTHRP2,CX3CR1,S1PR5B,XK,CRHR1,MLN,CCR3,GPR55,ACKR4 |
| G alpha (s) signalling events | PTHLH,GCGA,RAMP2,RXFP2,DRD5,ADCYAP1B,VIP2,PTH2,PTHLHA,PDE10A |
| Amyloid formation | RHBDL1,CEACAM21,HIST4H4,SAA1,SEMG1,TGFBI,NAT8,TTR,HIST2H3C,HIST3H2BB |
| Metabolism of proteins | LMAN2,SEC22C,CDX2,EEF1A1,TOMM7,TRAPPC9,TBCE,TUBA1B,FBXW4,VBP1 |
| Endothelin | CNN1,MYL1,EDNRA,ECE1,EDN1,RAMP1,CALCRL,EDNRB |
| GPCR downstream signaling | DRD2,CHRM1,OR4D2,OR52J3,TAC2,PROK1,DRD4,CCR7,OXGR1A.1,RLN2 |
Protein Function
CALCA has several biochemical functions, for example, calcitonin receptor binding,hormone activity,identical protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CALCA itself. We selected most functions CALCA had, and list some proteins which have the same functions with CALCA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | TPX2,PODXL2,C16orf48,EHMT1,DCDC2,PIF1,IVL,SHE,SFMBT1,FMNL3 |
| receptor binding | C1QTNF2,FGF10B,ICOSLG,CCL13,HAMP,CRTAM,LTA,FGF13B,GFRA1,PLA2G1B |
| protein complex binding | ADM2,PPARA,CRIPT,Ctsl,EP300,NOG,CPD,FLCN,ATM,TXN2 |
| calcitonin receptor binding | RAMP1 |
| identical protein binding | DVL1,COIL,TRIP10,SUN2,VPS4B,BTK,DAPK3,HOOK3,KCTD17,DYNLT1B |
| hormone activity | TTR,IGF2B,ADCYAP1B,IGF3,MLN,VIP,GCGB,INS,AVP,GIP |
Interacting Protein
CALCA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CALCA here. Most of them are supplied by our site. Hope this information will be useful for your research of CALCA.
ATP2B4;ATP2B2;CALCR
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References
- Tavares, E; Maldonado, R; et al. Immunoneutralization of Endogenous Aminoprocalcitonin Attenuates Sepsis-Induced Acute Lung Injury and Mortality in Rats. AMERICAN JOURNAL OF PATHOLOGY 184:3069-3083(2014).
- Camacho, CP; Lindsey, SC; et al. Measurement of Calcitonin and Calcitonin Gene-Related Peptide mRNA Refines the Management of Patients with Medullary Thyroid Cancer and May Replace Calcitonin-Stimulation Tests. THYROID 23:308-316(2013).
