CA2

  • Official Full Name

    Carbonic anhydrase II
  • Overview

    Essential for bone resorption and osteoclast differentiation (By similarity). Reversible hydration of carbon dioxide. Can hydrates cyanamide to urea. Involved in the regulation of fluid secretion into the anterior chamber of the eye.
  • Synonyms

    CA 2;CA II;CA-II;CA2;CAC;CAH2_HUMAN;CAII;Car 2;Carbonate dehydratase II;Carbonic anhydrase 2;Carbonic anhydrase B;Carbonic anhydrase C;Carbonic anhydrase II;Carbonic dehydratase;EC 4.2.1.1;IUB: 4.2.1.1;CA, HUMAN LIVER;CA1, BOVINE ERYTHROCYTES;CARBONATE DEHYDRATASE;CARBONATE HYDRO-LYASE;CARBONIC ANHYDRASE;PANCREAS, BOVINE;carbonic anhydrase from bovine erythro-cytes;Dehydratase, carbonate;TDX-02;Car-2;Ltw-5;Lvtw-5;AI131712;Car2

Recombinant Proteins

  • Human
  • Dog
  • Mouse
  • Sheep
  • Rat
  • Rabbit
  • Rhesus macaque
  • Chicken
  • Zebrafish
  • Capsicum annuum (Bell pepper)
  • E.coli
  • Dog
  • Human
  • Mouse
  • Sheep
  • Rat
  • Rabbit
  • Rhesus Macaque
  • Wheat Germ
  • Mammalian Cells
  • HEK293
  • In Vitro Cell Free System
  • Yeast
  • GST
  • His
  • Non
  • Avi&His&Fc
  • Myc&DDK
  • Flag
  • His&SUMO
  • His&Fc&Avi
Cat.# Product name Source (Host) Species Tag Protein Length Price
CA2-10619H Recombinant Human CA2, GST-tagged E.coli Human GST 1-260a.a.
CA2-864H Recombinant Human CA2, His tagged E.coli Human His 1-260 a.a.
CA2-29D Native Dog Carbonic Anhydrase II (CA2) Protein Dog Dog Non
CA2-30H Native Human Carbonic Anhydrase II (CA2) Protein Human Human Non
CA2-31M Native Mouse Carbonic Anhydrase II (CA2) Protein Mouse Mouse Non
CA2-32S Native Sheep Carbonic Anhydrase II (CA2) Protein Sheep Sheep Non
CA2-33R Native Rat Carbonic Anhydrase II (CA2) Protein Rat Rat Non
CA2-34R Native Rabbit Carbonic Anhydrase II (CA2) Protein Rabbit Rabbit Non
CA2-35R Native Rhesus monkey Carbonic Anhydrase II (CA2) Protein Rhesus Macaque Rhesus macaque Non
CA2-0237H Active Recombinant Human CA2 Protein E.coli Human Non
CA2-219H Active Recombinant Human CA2 E.coli Human Non
Car2-886M Active Recombinant Mouse Car2 Protein, His-tagged E.coli Mouse His 1-260 a.a.
CA2-0238H Recombinant Human CA2 Protein, GST-Tagged Wheat Germ Human GST
CA2-1057R Recombinant Rat CA2 Protein Mammalian Cells Rat His
CA2-1114H Active Recombinant Human CA2 protein, His-tagged E.coli Human His Met 1-Lys 260
CA2-144H Recombinant Human Carbonic Anhydrase II E.coli Human Non
CA2-220H Recombinant Human CA2, C13&N15-labeled HEK293 Human Non 1-260 a.a.
CA2-27265TH Recombinant Human CA2 E.coli Human Non Full L.
CA2-597R Recombinant Rhesus monkey CA2 Protein, His-tagged Mammalian Cells Rhesus macaque His
CA2-6869C Recombinant Chicken CA2 Mammalian Cells Chicken His
CA2-7676C Recombinant Chicken CA2 protein, His-tagged E.coli Chicken His Met1~Gln260
CA2-7678R Recombinant Rhesus monkey CA2 protein, His-tagged E.coli Rhesus macaque His Met1~Lys260
CA2-9899Z Recombinant Zebrafish CA2 Mammalian Cells Zebrafish His
Car2-1191M Recombinant Mouse Carbonic Anhydrase 2, His-tagged Mouse Mouse His 1-260 a.a.
CAR2-2718M Recombinant Mouse CAR2 Protein Mammalian Cells Mouse His
Car2-7677R Recombinant Rat Car2 protein, His-tagged E.coli Rat His Met1~Lys260
CA2-7915HCL Recombinant Human CA2 293 Cell Lysate HEK293 Human Non
CA2-0615H Recombinant Human CA2 Protein (Met1-Lys260), N-His-tagged E.coli Human His Met1-Lys260
CA2-114H Recombinant Human CA2 Protein, His-tagged HEK293 Human His 260
CA2-1158M Recombinant Mouse CA2 Protein, His (Fc)-Avi-tagged HEK293 Mouse Avi&His&Fc
CA2-1158M-B Recombinant Mouse CA2 Protein Pre-coupled Magnetic Beads HEK293 Mouse
CA2-201H Recombinant Human CA2 Protein, MYC/DDK-tagged, C13 and N15-labeled HEK293 Human Myc&DDK
CA2-2060HFL Recombinant Full Length Human CA2 Protein, C-Flag-tagged Mammalian Cells Human Flag Full L.
CA2-2583H Active Recombinant Human CA2 protein E.coli Human Non Ser2-Lys260
CA2-2617H Recombinant Human CA2 protein, His-SUMO-tagged E.coli Human His&SUMO 2-260aa
CA2-2734HF Recombinant Full Length Human CA2 Protein, GST-tagged In Vitro Cell Free System Human GST Full L. 260 amino acids
CA2-354H Recombinant Human CA2 protein, His-tagged HEK293 Human His 259
Ca2-421R Recombinant Rat Ca2 protein(2-260aa), His-tagged E.coli Rat His 2-260aa
CA2-425R Recombinant Rhesus Macaque CA2 Protein, His (Fc)-Avi-tagged HEK293 Rhesus macaque His&Fc&Avi
CA2-425R-B Recombinant Rhesus Macaque CA2 Protein Pre-coupled Magnetic Beads HEK293 Rhesus macaque
CA2-479H Recombinant Human CA2 Protein, His (Fc)-Avi-tagged HEK293 Human His&Fc&Avi
CA2-479H-B Recombinant Human CA2 Protein Pre-coupled Magnetic Beads HEK293 Human
Ca2-543R Recombinant Rat Ca2 protein, His-tagged Yeast Rat His 2-260aa
CA2-716R Recombinant Rat CA2 Protein, His (Fc)-Avi-tagged HEK293 Rat His&Fc&Avi
CA2-716R-B Recombinant Rat CA2 Protein Pre-coupled Magnetic Beads HEK293 Rat
Car2-765M Recombinant Mouse Car2 Protein, MYC/DDK-tagged HEK293 Mouse Myc&DDK
RFL11115CF Recombinant Full Length Capsicum Annuum Beta-Carotene Hydroxylase 2, Chloroplastic(Ca2) Protein, His-Tagged E.coli Capsicum annuum (Bell pepper) His Full L. Full Length of Mature Protein (100-316)

    Involved Pathway

    CA2 involved in several pathways and played different roles in them. We selected most pathways CA2 participated on our site, such as Nitrogen metabolism,Proximal tubule bicarbonate reclamation,Collecting duct acid secretion, which may be useful for your reference. Also, other proteins which involved in the same pathway with CA2 were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.

    Pathway Name Pathway Related Protein
    Proximal tubule bicarbonate reclamation Car4,ATP1A1,ATP1A2,SLC4A4,ATP1B1,GLUD2,CA4,ATP1B2,MDH1,ATP1A4
    Bile secretion AQP8,RXRA,ATP1B3,SLC2A1,SLCO1A4,SLC51B,SLC10A2,ADCY3,CFTR,SLC51A
    Pancreatic secretion TPCN2,PLA2G3,PNLIP,PLA2G2F,ATP1A4,RAP1B,PLA2G2D,ATP2A3,CPB1,PNLIPRP1
    Gastric acid secretion Slc4a2,CALM3,PRKACA,PRKACG,GAST,ATP1A3,ATP1B1,PLCB1,ATP1A2,CAMK2D
    Collecting duct acid secretion ATP6V0D1,ATP6V0D2,TCIRG1,ATP6V1G2,ATP6V1B2,CLCNKB,Car2,ATP6V0E2,ATP6V1G3,ATP6V1F
    Nitrogen metabolism CA4B,GLULB,CAHZ,CA9,CAR5A,Car2,GLUD1,CA8,GLULA,CA13

    Protein Function

    CA2 has several biochemical functions, for example, arylesterase activity,carbonate dehydratase activity,protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by CA2 itself. We selected most functions CA2 had, and list some proteins which have the same functions with CA2. You can find most of the proteins on our site.

    Function Related Protein
    carbonate dehydratase activity Car14,CA4B,CAR6,CAR1,CA3,CAR13,CA15B,CA14,CA13,CAHZ
    protein binding MED28,OSBPL3,SYTL2,KIF21A,LUM,GOSR2,CD82,XIRP2,TOLLIP,ARAP1
    zinc ion binding CA12,GLO1,AMFR,FTR14,ZCWPW1,MTA3,BTR29,RYBPB,KDM5BA,LDB3A
    arylesterase activity APMAP,PON3,PON1,C20orf3,Car2,PON2,CAR1,CA1

    Interacting Protein

    CA2 has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with CA2 here. Most of them are supplied by our site. Hope this information will be useful for your research of CA2.

    Cdk1;PCNA;USP42;ANKZF1;PTCHD2

    Resources

    References

    • Kale, SL; Arora, N; et al. Per a 10 activates human derived epithelial cell line in a protease dependent manner via PAR-2. IMMUNOBIOLOGY 220:525-532(2015).
    • Zhang, Y; Li, H; et al. Melatonin-mediated inhibition of Purkinje neuron P-type Ca2+ channels in vitro induces neuronal hyperexcitability through the phosphatidylinositol 3-kinase-dependent protein kinase C delta pathway. JOURNAL OF PINEAL RESEARCH 58:321-334(2015).

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