C1QA
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Official Full Name
complement component 1, q subcomponent, alpha polypeptide -
Overview
C1q associates with the proenzymes C1r and C1s to yield C1, the first component of the serum complement system. The collagen-like regions of C1q interact with the Ca(2+)-dependent C1r(2)C1s(2) proenzyme complex, and efficient activation of C1 takes place on interaction of the globular heads of C1q with the Fc regions of IgG or IgM antibody present in immune complexes. -
Synonyms
C1QA;complement component 1, q subcomponent, alpha polypeptide;C1q;AI255395;complement C1q subcomponent subunit A
Recombinant Proteins
- Human
- Rat
- Mouse
- Zebrafish
- E.coli
- Human Serum
- Mammalian Cell
- HEK293
- Yeast
- Insect Cell
- GST
- Non
- His
- His&T7
- His&Fc&Avi
- His&Myc
- His&SUMO
Involved Pathway
C1QA involved in several pathways and played different roles in them. We selected most pathways C1QA participated on our site, such as Complement and coagulation cascades,Prion diseases,Pertussis, which may be useful for your reference. Also, other proteins which involved in the same pathway with C1QA were listed below. Creative BioMart supplied nearly all the proteins listed, you can search them on our site.
| Pathway Name | Pathway Related Protein |
|---|---|
| Staphylococcus aureus infection | CFI,C1QC,C3,PLG,FCGR1A,ITGB2,H2-AA,SELPLG,Itgam&Itgb2,CFB |
| Prion diseases | MAPK3,C8B,LAMC1,C6,STIP1,PRNP,CASP12,C8A,BAX,HSPA5 |
| Systemic lupus erythematosus | HIST1H2AI,HLA-DQA1,HIST1H2BP,HLA-DQA2,HLA-DPA1,CD40,C4A,HIST1H4I,C1QB,H2AFY |
| Complement and coagulation cascades | LOC100514666,MASP2,TFPI,MBL2,VWF,SERPINC1,C7,CD59A,SERPINA5,GM5077 |
| Pertussis | C2,C1S,C3,MYD88,IRAK1,IL6,RELA,C4BP,AMCF-II,CALM1 |
| Chagas disease (American trypanosomiasis) | IKBKG,Ccl12,MAPK12,GNAO1,NFKBIA,TGFB3,PLCB1,GNA11,CCL3L3,CALR |
Protein Function
C1QA has several biochemical functions, for example, protein binding. Some of the functions are cooperated with other proteins, some of the functions could acted by C1QA itself. We selected most functions C1QA had, and list some proteins which have the same functions with C1QA. You can find most of the proteins on our site.
| Function | Related Protein |
|---|---|
| protein binding | CNGA1,CD276,VSIG4,TMEM140,KLK4,LRRK2,THRAP3,PSMB3,TCEAL5,HHIPL2 |
Interacting Protein
C1QA has direct interactions with proteins and molecules. Those interactions were detected by several methods such as yeast two hybrid, co-IP, pull-down and so on. We selected proteins and molecules interacted with C1QA here. Most of them are supplied by our site. Hope this information will be useful for your research of C1QA.
C1QB;C1QC;LRP1;SGTA;PIAS2;PPP1CC;BAG6;PPP1CA;SLC25A47;GNPNAT1;HIPK3;q9k5j5_bacan;UBQLN2;UBQLN1;APOA1
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References
- Yuan, HY; Chen, R; et al. Crystallization and preliminary crystallographic studies of the complement 1qA globular domain from zebrafish, Dare-C1qAgD. ACTA CRYSTALLOGRAPHICA SECTION F-STRUCTURAL BIOLOGY COMMUNICATIONS 70:911-914(2014).
- Trouw, LA; Daha, N; et al. Genetic variants in the region of the C1q genes are associated with rheumatoid arthritis. CLINICAL AND EXPERIMENTAL IMMUNOLOGY 173:76-83(2013).
