Recombinant Mouse C1qa protein, His & T7-tagged

• Cat.No.: C1qa-7932M
• Product Overview: Recombinant Mouse C1qa aa. (Glu23~Ala245 (Accession # P98086)) fused with N-terminal His & T7 tag was produced in E. coli cells.

Specification

• Source: E. coli
• Species: Mouse
• Tag: His&T7
• Form: Freeze-dried powder
• Molecular Mass: Predicted Molecular Mass: 27.4kDa
• Protein length: Glu23~Ala245
• Endotoxin: <1.0EU per 1ug (determined by the LAL method)
• Purity: >95%
• Characteristic: The isoelectric point is 9.6.
• Applications: SDS-PAGE; WB; ELISA; IP
• Stability: The thermal stability is described by the loss rate of the target protein. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37°C for 48h, and no obvious degradation and precipitation were observed. (Referring from China Biological Products Standard, which was calculated by the Arrhenius equation.) The loss of this protein is less than 5% within the expiration date under appropriate storage condition.
• Storage: Avoid repeated freeze/thaw cycles. Store at 2-8°C for one month. Aliquot and store at -80°C for 12 months.
• Storage Buffer: Supplied as lyophilized form in 20mM Tris, 150mM NaCl, pH8.0, containing 1mM EDTA, 1mM DTT, 0.01% sarcosyl, 5% trehalose, and preservative.
• Reconstitution: Reconstitute in sterile ddH2O.

Gene Information

• Gene Name: C1qa complement component 1, q subcomponent, alpha polypeptide [ Mus musculus (house mouse) ]
• Official Symbol: C1qa
• Synonyms: C1qa; complement component 1, q subcomponent, alpha polypeptide; C1q; AI255395; complement C1q subcomponent subunit A
• Gene ID: 12259
• mRNA Refseq: NM_007572.2
• Protein Refseq: NP_031598.2
• UniProt ID: P98086

Reviews

01/23/2022

Excellent quality, fast delivery.

03/01/2021

Reliable in experiments, quality.

02/09/2020

Product met all requirements.

Q&As

What role does C1QA play in the clearance of apoptotic cells?

It plays a role in recognizing and promoting the removal of apoptotic cells.

What therapeutic strategies are being explored involving C1QA modulation?

Strategies are being explored to modulate C1QA activity in conditions like lupus and rheumatoid arthritis.

Are there known genetic mutations in C1QA associated with specific health conditions?

Genetic deficiencies in C1QA are linked to increased susceptibility to infections and autoimmune conditions.

In which immune responses is C1QA critically involved?

C1QA is involved in immune responses against pathogens and in the clearance of immune complexes.

How is C1QA implicated in autoimmune diseases?

Dysregulation of C1QA can contribute to impaired clearance of immune complexes, leading to autoimmune diseases.

How does C1QA contribute to the activation of the complement system?

It binds to antibodies or C-reactive protein on pathogen surfaces, activating C1r and C1s in the C1 complex.

What is the primary function of C1QA in the immune system?

C1QA is a vital component of the C1 complex, initiating the classical complement pathway.